Acute and chronic toxicity of nickel oxide nanoparticles to Daphnia magna: The influence of algal enrichment

Gong, Ning; Shao, Kuishuang; Li, Guangyao; Sun, Yeqing

doi:10.1016/j.impact.2016.08.003

Cited by 20 publications

(10 citation statements)

References 16 publications

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“…It is no wonder that NiO-NP toxicology has been, and still is, the subject-matter of numerous experimental studies. However, the prevailing majority of the relevant studies were done in vitro on cultured cells (e.g., [3,4,5,6,7]) or sometimes in vivo on daphnia [8] and drosophila [9], while the experiments on laboratory rodents used mostly single-shot or repeated intratracheal instillations [7,10,11,12,13,14,15,16] and, occasionally, oral administration [17].…”

Section: Introductionmentioning

confidence: 99%

Toxic Effects of Low-Level Long-Term Inhalation Exposures of Rats to Nickel Oxide Nanoparticles

Sutunkova

Solovyeva

Minigalieva

et al. 2019

IJMS

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Rats were exposed to nickel oxide nanoparticles (NiO-NP) inhalation at 0.23 ± 0.01 mg/m3 for 4 h a day 5 times a week for up to 10 months. The rat organism responded to this impact with changes in cytological and some biochemical characteristics of the bronchoalveolar lavage fluid along with a paradoxically little pronounced pulmonary pathology associated with a rather low chronic retention of nanoparticles in the lungs. There were various manifestations of systemic toxicity, including damage to the liver and kidneys; a likely allergic syndrome as indicated by some cytological signs; transient stimulation of erythropoiesis; and penetration of nickel into the brain from the nasal mucous membrane along the olfactory pathway. Against a picture of mild to moderate chronic toxicity of nickel, its in vivo genotoxic effect assessed by the degree of DNA fragmentation in nucleated blood cells (the RAPD test) was pronounced, tending to increasing with the length of the exposure period. When rats were given orally, in parallel with the toxic exposure, a set of innocuous substances with differing mechanisms of expected bioprotective action, the genotoxic effect of NiO-NPs was found to be substantially attenuated.

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Section: Introductionmentioning

confidence: 99%

Toxic Effects of Low-Level Long-Term Inhalation Exposures of Rats to Nickel Oxide Nanoparticles

Sutunkova

Solovyeva

Minigalieva

et al. 2019

IJMS

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“…In addition to nano‐Ni particles and aggregates adsorbing/adhering to external surfaces of organisms (Gong et al 2016; Sousa et al 2018a, 2018b), nano‐Ni particles sometimes cross membranes and accumulate in intact cells (Shaw and Handy 2011; Oukarroum et al 2017), although not always (e.g., Sousa et al 2018a). Even the simple physical burden of nano‐Ni particles attached to an organism might be detrimental at high exposure concentrations that result in particles covering the entire surface of the organism (e.g., Daphnia magna ; Figure 3F in Gong et al 2016). Ingestion of particles can lead to accumulation of nano‐Ni in the gastrointestinal tract (Ispas et al 2009; Özel et al 2014; Ates et al 2016; Figures 3B–D in Gong et al 2016), leading to potential intestinal histopathologies (Ispas et al 2009), disruption of gut physiology (e.g., Özel et al 2014), and alteration of the microbial community in the intestine (Bagirov et al 2019).…”

Section: Resultsmentioning

confidence: 99%

Toxicity of Nanoparticulate Nickel to Aquatic Organisms: Review and Recommendations for Improvement of Toxicity Tests

Meyer¹,

Lyons-Darden²,

Garman³

et al. 2020

Enviro Toxic and Chemistry

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We reviewed the literature on toxicity of nanoparticulate nickel (nano-Ni) to aquatic organisms, from the perspective of relevance and reliability in a regulatory framework. Our main findings were 1) much of the published nano-Ni toxicity data is of low or medium quality in terms of reporting key physical-chemical properties, methodologies, and results, compared with published dissolved nickel studies; and 2) based on the available information, some common findings about nanoparticle (NP) toxicity are not supported for nano-Ni. First, we concluded that nanoparticulate elemental nickel and nickel oxide, which differ in chemical composition, generally did not differ in their toxicity. Second, there is no evidence that the toxicity of nano-Ni increases as the size of the NPs decreases. Third, for most organisms tested, nano-Ni was not more toxic on a mass-concentration basis than dissolved Ni. Fourth, there is conflicting evidence about whether the toxicity is directly caused by the NPs or by the dissolved fraction released from the NPs. However, no evidence suggests that any of the molecular, physiological, and structural mechanisms of nano-Ni toxicity differ from the general pattern for many metal-based nanomaterials, wherein oxidative stress underlies the observed effects. Physical-chemical factors in the design and conduct of nano-Ni toxicity tests are important, but often they are not adequately reported (e.g., characteristics of dry nano-Ni particles and of wetted particles in exposure waters; exposure-water chemistry).

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“…The addition of algae could potentially change the toxicant exposure for the test organism. One possible explanation may be the internalisation of metals by algae, leading to foodborne metal exposure [62,66,67,68] especially in lake Raku water with lower ionic strength [22]. The concurrent sedimentation (or heteroagglomeration) (see 3.1.1) of NP and algae that was observed in AFW could have increased their simultaneous uptake due to daphnids turning to bottom-feeding.…”

Section: Discussionmentioning

confidence: 99%

Combined Effects of Test Media and Dietary Algae on the Toxicity of CuO and ZnO Nanoparticles to Freshwater Microcrustaceans Daphnia magna and Heterocypris incongruens: Food for Thought

et al. 2018

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The chemical composition of the test medium as well as the presence of algae (microcrustaceans’ food) affects the bioavailability and thus the toxicity of metal nanoparticles (NP) to freshwater microcrustaceans. This study evaluated the effect of the addition of algae (Rapidocelis subcapitata at 7.5 × 106 cells/mL) on the toxicity of CuO (primary size 22–25 nm) and ZnO NP (10–15 nm) to planktic Daphnia magna and benthic Heterocypris incongruens in artificial (mineral) and natural freshwater (lake water). The toxicity of ionic controls, CuSO4 and ZnSO4, was evaluated in parallel. When algae were added and the toxicity was tested in mineral medium, 48 h EC50 of CuO and ZnO NP to D. magna was ~2 mg metal/L and 6-day LC50 of H. incongruens was 1.1 mg metal/L for CuO and 0.36 mg metal/L for ZnO. The addition of algae to D. magna test medium mitigated the toxicity of CuO and ZnO NP 4–11-fold when the test was conducted in natural water but not in the artificial freshwater. The addition of algae mitigated the toxicity of CuSO4 (but not ZnSO4) to D. magna at least 3-fold, whatever the test medium. In the 6-day H. incongruens tests (all exposures included algae), only up to 2-fold differences in metal NP and salt toxicity between mineral and natural test media were observed. To add environmental relevance to NP hazard assessment for the freshwater ecosystem, toxicity tests could be conducted in natural water and organisms could be fed during the exposure.

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Acute and chronic toxicity of nickel oxide nanoparticles to Daphnia magna: The influence of algal enrichment

Cited by 20 publications

References 16 publications

Toxic Effects of Low-Level Long-Term Inhalation Exposures of Rats to Nickel Oxide Nanoparticles

Toxic Effects of Low-Level Long-Term Inhalation Exposures of Rats to Nickel Oxide Nanoparticles

Toxicity of Nanoparticulate Nickel to Aquatic Organisms: Review and Recommendations for Improvement of Toxicity Tests

Combined Effects of Test Media and Dietary Algae on the Toxicity of CuO and ZnO Nanoparticles to Freshwater Microcrustaceans Daphnia magna and Heterocypris incongruens: Food for Thought

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