Acute and chronic stress effects on open field activity in the rat: Implications for a model of depression

Katz, Richard J.; Roth, Kevin A.; Carroll, Bernard J.

doi:10.1016/0149-7634(81)90005-1

Cited by 779 publications

(391 citation statements)

References 22 publications

(23 reference statements)

Supporting

Mentioning

339

Contrasting

Unclassified

Order By: Relevance

“…Their engagement in their immediate surroundings may be termed limited and passive. In analogy, engagement of both a social and nonsocial nature is also typically disrupted in clinical depression (Hall, 1934;Katz et al, 1981). The effects of CUMS on open-field activity of the rat in our study implicated that the model of depression was established successfully.…”

Section: Discussionmentioning

confidence: 52%

Mifepristone Repairs Region-Dependent Alteration of Synapsin I in Hippocampus in Rat Model of Depression

Han

Wang

et al. 2007

Neuropsychopharmacol

View full text Add to dashboard Cite

Clinical investigations present much evidence that the glucocorticoid receptor (GR) antagonist mifepristone leads to a rapid amelioration of depression. The molecular mechanisms of mifepristone involved in the treatment of depression are not fully understood. Depression is associated with hippocampal plasticity, for which increased excitatory amino acid (EAA) release in CA3 induced by chronic stress is responsible, and glucocorticoids have a permissive role and act synergistically with EAAs in producing neuronal damage. Moreover, glucocorticoids increase synapsin I, which has a key role in the release of neurotransmitter, including EAAs. Hereby, we hypothesize that major depression involves synapsin I alteration and that mifepristone blocks this alteration. In the present study, we observed both the expression of hippocampal synapsin I and depression-associated behavior in a rat model of depression induced by chronic unpredictable mild stress (CUMS). The result showed that a region-dependent synapsin I alteration occurs in the rat hippocampus after 21 days of CUMS, that is, it increases in dentate gyrus (DG)/CA3 and decreases in the CA1 region. Correlation analysis indicated that the decrease of synapsin I in CA1 is highly correlated with the increase in the DG/CA3 subfield. Simultaneously, the region-dependent alteration of synapsin I is correlated with depression-associated behaviors. Both the alteration of synapsin I and the depression-associated behavior were rapidly restored after treatment with mifepristone for 1 week. The result suggests that the molecular mechanism underlying the treatment of depression with mifepristone is associated with the rapid repair of the synaptic alteration.

show abstract

Section: Discussionmentioning

confidence: 52%

Mifepristone Repairs Region-Dependent Alteration of Synapsin I in Hippocampus in Rat Model of Depression

Han

Wang

et al. 2007

Neuropsychopharmacol

View full text Add to dashboard Cite

show abstract

“…However, data from recent studies may be indicative of such association. For instance, a higher cortical dopaminergic response to an unavoidable aversive stimulus-restraint-was found in animals previously submitted to a procedure with persistent and dissimilar stressors )-an animal model of depression- (Katz et al 1981;Willner 1991). In line with such evidence, a higher activation of cortical DA response following uncontrollable shocks was found as compared to controllable shocks (Carlson et al 1993;Cabib and Puglisi-Allegra 1994) using the learned helplessness paradigm-another model of depression.…”

mentioning

confidence: 64%

Influence of Different Antidepressant Drugs on the Effect of Chronic Variable Stress on Restraint-Induced Dopamine Release in Frontal Cortex

Cuadra

Zurita

Gioino

et al. 2001

Neuropsychopharmacology

View full text Add to dashboard Cite

“…These evaluations were performed because food deprivation, which is used in many behavior tasks as a motivating stimulus, may also be an acute stressor (Katz et al 1981a;Gamaro et al 2003). The behavioral tests were performed by the same person blinded to the experimental group.…”

Section: Sweet Food Consumption (Anhedonia Test)mentioning

confidence: 99%

Behavioral Responses in Rats Submitted to Chronic Administration of Branched-Chain Amino Acids

et al. 2013

View full text Add to dashboard Cite

Maple syrup urine disease (MSUD) is an inborn metabolism error caused by a deficiency of branched-chain a-keto acid dehydrogenase complex activity. This blockage leads to an accumulation of the branched-chain amino acids (BCAA) leucine, isoleucine, and valine, as well as their corresponding a-keto and a-hydroxy acids. Previous reports suggest that MSUD patients are at high risk for chronic neuropsychiatric problems. Therefore, in this study, we assessed variables that suggest depressive-like symptoms (anhedonia as measured by sucrose intake, immobility during the forced swimming test and body and adrenal gland weight) in rats submitted to chronic administration of BCAA during development. Furthermore, we determined if these parameters were sensitive to imipramine and N-acetylcysteine/deferoxamine (NAC/DFX). Our results demonstrated that animals subjected to chronic administration of branched-chain amino acids showed a decrease in sucrose intake without significant changes in body weight. We also observed an increase in adrenal gland weight and immobility time during the forced swimming test. However, treatment with imipramine and NAC/DFX reversed these changes in the behavioral tasks. In conclusion, this study demonstrates a link between MSUD and depression in rats. Moreover, this investigation reveals that the antidepressant action of NAC/DFX and imipramine might be associated with their capability to maintain pro-/anti-oxidative homeostasis.

show abstract

Acute and chronic stress effects on open field activity in the rat: Implications for a model of depression

Cited by 779 publications

References 22 publications

Mifepristone Repairs Region-Dependent Alteration of Synapsin I in Hippocampus in Rat Model of Depression

Mifepristone Repairs Region-Dependent Alteration of Synapsin I in Hippocampus in Rat Model of Depression

Influence of Different Antidepressant Drugs on the Effect of Chronic Variable Stress on Restraint-Induced Dopamine Release in Frontal Cortex

Behavioral Responses in Rats Submitted to Chronic Administration of Branched-Chain Amino Acids

Contact Info

Product

Resources

About