Acute and chronic psychological stress as risk factors for cardiovascular disease: Insights gained from epidemiological, clinical and experimental studies

Lagraauw, H. Maxime; Kuiper, Johan; Bot, Ilze

doi:10.1016/j.bbi.2015.08.007

Cited by 200 publications

(147 citation statements)

References 146 publications

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“…A Dutch cohort study found that among the childhood trauma subtypes and personality traits, sexual abuse was the primary factor that correlated negatively with serum cholesterol and abdominal circumference measurements[37]. Recurrent stressful events may induce a subtle chronic inflammatory response, enough to contribute to the progression of atherosclerosis and increased the risk of developing CAD[38]. Our results highlight the importance of the assessment of childhood trauma in patients with CVD, as the severity of trauma may predict depression in this population.…”

Section: Discussionmentioning

confidence: 99%

Childhood trauma and factors associated with depression among inpatients with cardiovascular disease

Barreto

Garcia

Prado

et al. 2017

WJP

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AIMTo identify factors associated with depressive symptoms among inpatients with cardiovascular disease (CVD).METHODSThis is a cross-sectional study performed in a subsample of a large cross-sectional research that investigated affective disorders and suicide behaviour among inpatients hospitalized in non-surgical wards of the University Hospital of the Federal University of Minas Gerais from November 2013 to October 2015. Sociodemographic and clinical data were obtained through a structured interview and medical record review. Depression was assessed by the depression subscale of the Hospital Anxiety and Depression Scale, with scores ≥ 8 considered as positive screening for depression. We used the Fageström Test for Nicotine Dependence to characterize nicotine dependence. For assessing resilience and early-life trauma, we used the raw scores of the Wagnild and Young Resilience Scale and Childhood Trauma Questionnaire, respectively.RESULTSAt endpoint, we included 137 subjects. Thirty-eight (27.7%) subjects presented depressive symptoms and nine (23.7%) of those were receiving antidepressant treatment during hospitalization. The female sex; a lower mean educational level; a greater prevalence of previous suicide attempts; a higher level of pain; a higher prevalence of family antecedents of mental disorders; a lower resilience score; and higher childhood trauma score were the factors significantly associated with screening positive for major depression (P < 0.05). Multivariate analysis demonstrated that the factors independently associated with the depressive symptoms were a higher childhood trauma severity (OR = 1.06; P = 0.004); moderate to severe nicotine dependence (OR = 8.58; P = 0.008); and the number of previous hospital admissions (OR = 1.11; P = 0.034). The obtained logistic model was considered valid, indicating that the three factors together distinguished between having or not depressive symptoms, and correctly classified 74.6% of individuals in the sample.CONCLUSIONOur results demonstrate that inpatients presenting both CVD and a positive screening for depression are more prone to have antecedents of childhood trauma, nicotine dependence and a higher number of previous hospitalizations.

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Section: Discussionmentioning

confidence: 99%

Childhood trauma and factors associated with depression among inpatients with cardiovascular disease

Barreto

Garcia

Prado

et al. 2017

WJP

View full text Add to dashboard Cite

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“…The association between psychological stress and cardiovascular disease has been documented in a number of epidemiological, clinical and experimental studies, as recently reviewed by Lagraauw et al (Lagraauw et al 2015). Bouts of psychological stress also trigger cardiac events and this effect may be stronger in individuals with unfavorable psychological attributes, such as low coping skills and depressive mood (Edmondson et al 2013).…”

Section: Introductionmentioning

confidence: 98%

Stress-induced release of matrix metalloproteinase-9 in patients with coronary artery disease: The possible influence of cortisol

Lundberg

Jonsson

Stenmark

et al. 2016

Psychoneuroendocrinology

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Stress-induced release of matrix metalloproteinase-9 in patients with coronary artery disease: The possible influence of cortisol, Psychoneuroendocrinology, 2016. 73() AbstractStress and inflammation are both important risk factors for coronary artery disease (CAD). However, the susceptibility to stress-induced inflammation and its determinants have been little explored in patients with CAD. Here, our aim was to study the stress-induced inflammatory response, more precisely the early release of matrix metalloproteinase (MMP)-9, and its association with cortisol response in patients with CAD. Sixty-four patients underwent a standardized laboratory stress test.The stress-induced release of MMP-9 was closely associated with the release of other neutrophilassociated proteins, MMP-8 and myeloperoxidase (MPO). It also showed a large variation among patients, as did cortisol. Twenty minutes after stress, a negative association between changes in MMP-9 and cortisol was seen (p<0.01). In vitro, dexamethasone reduced the IL-8-mediated release of MMP-9 from neutrophils, indicating that glucocorticoids may exert rapid effects on neutrophil activation. Further characterization of patients revealed that stress-induced release of MMP-9 was related to leukocyte telomere shortening and increased ultrasound-assessed plaque occurrence in the carotid arteries, but not to other characteristics such as age, gender or psychological background factors. The susceptibility to stress-induced release of MMP-9 may thus have impact on disease phenotype. Stress tests can be useful to identify CAD patients in need of novel prevention and treatment strategies.

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“…Cortisol was chosen as an indicator of physiological health for several reasons. First, chronic stress is a significant predictor of immune functioning and cardiovascular health, with small-to medium-effect sizes (e.g., Lagraauw, Kuiper, & Bot, 2015;Segerstrom & Miller, 2004). Importantly, cortisol is one of the primary pathways through which prolonged stress negatively impacts health (Cohen et al, 1995;Dhabhar, 2009;Golbidi, Frisbee, & Laher, 2015).…”

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confidence: 99%

Circumnavigating the cost of support

Crockett¹,

Morrow²,

Muyshondt³

2016

Journal of Social and Personal Relationships

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Although social support is typically associated with a number of health benefits, for some individuals support worsens outcomes, likely because receiving support can undermine feelings of competence. Some have argued that invisible support (i.e., support that recipients do not recognize as help) can reduce negative support-related health consequences (Bolger, Zuckerman, & Kessler, 2000); still, the physiological benefits of invisible support have yet to be established and likely differ as a function of self-efficacy. The purpose of this study was to investigate how visibility of support and self-efficacy interact to affect the cortisol reactivity of a support recipient. In a 2 (self-efficacy: high vs. low) × 2 (support visibility: visible vs. invisible) between-subjects, experimental design, 74 undergraduate students were primed for either high or low self-efficacy using false feedback. Participants then received either visible or invisible support from a confederate while preparing a speech as part of the Trier Social Stress Task (Kirschbaum, Pirke, & Hellhammer, 1993). A series of repeated measures analyses of variance revealed that individuals primed to have high self-efficacy experienced cortisol increases in response to the speech task when they received visible support but not invisible support. By contrast, individuals primed to have low self-efficacy experienced increased cortisol when they received invisible support but not visible support. This research suggests that although invisible support can effectively buffer stress, it is not always the best support strategy.

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Acute and chronic psychological stress as risk factors for cardiovascular disease: Insights gained from epidemiological, clinical and experimental studies

Cited by 200 publications

References 146 publications

Childhood trauma and factors associated with depression among inpatients with cardiovascular disease

Childhood trauma and factors associated with depression among inpatients with cardiovascular disease

Stress-induced release of matrix metalloproteinase-9 in patients with coronary artery disease: The possible influence of cortisol

Circumnavigating the cost of support

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