Acute and chronic pancreatitis

Toskes, Phillip P.; Greenberger, Norton J.

doi:10.1016/0011-5029(83)90009-3

Cited by 56 publications

(5 citation statements)

References 88 publications

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“…Folic acid deficiency is often associated with alcoholism worldwide. There is a strong association of alcohol with acute and chronic pancreatitis, affecting 85 per 100 000/year in United States [13] . Long term alcohol abuse is a major risk factor for developing pancreatic disease.…”

Section: Introductionmentioning

confidence: 99%

Biochemical and Molecular Mechanisms of Folate Transport in Rat Pancreas; Interference with Ethanol Ingestion

2011

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Folic acid is an essential nutrient that is required for one-carbon biosynthetic processes and for methylation of biomolecules. Deficiency of this micronutrient leads to disturbances in normal physiology of cell. Chronic alcoholism is well known to be associated with folate deficiency which is due, in part to folate malabsorption. The present study deals with the mechanistic insights of reduced folate absorption in pancreas during chronic alcoholism. Male Wistar rats were fed 1 g/kg body weight/day ethanol (20% solution) orally for 3 months and the mechanisms of alcohol associated reduced folate uptake was studied in pancreas. The folate transport system in the pancreatic plasma membrane (PPM) was found to be acidic pH dependent one. The transporters proton coupled folate transporter (PCFT) and reduced folate carrier (RFC) are involved in folate uptake across PPM. The folate transporters were found to be associated with lipid raft microdomain of the PPM. Ethanol ingestion decreased the folate transport by reducing the levels of folate transporter molecules in lipid rafts at the PPM. The decreased transport efficiency of the PPM was reflected as reduced folate levels in pancreas. The chronic ethanol ingestion led to decreased pancreatic folate uptake. The decreased levels of PCFT and RFC expression in rat PPM were due to decreased association of these proteins with lipid rafts (LR) at the PPM.

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Section: Introductionmentioning

confidence: 99%

Biochemical and Molecular Mechanisms of Folate Transport in Rat Pancreas; Interference with Ethanol Ingestion

2011

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“…The bentiromide test will become abnormal at about 80% damage, and a serum trypsinogen value will be low at about 90% damage. Fecal fat determinations and fecal chymotrypsin or fecal elastase are abnormal at about 90% damage as well [14].…”

Section: Clinical Featuresmentioning

confidence: 99%

Update on diagnosis and management of chronic pancreatitis

Toskes

1999

Curr Gastroenterol Rep

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Chronic pancreatitis should be considered in all patients with unexplained abdominal pain. The importance of small duct disease without obvious radiographic abnormalities is an important new concept. It is meaningful for the clinician to define whether the patient with chronic pancreatitis has small duct or large duct disease. Diagnostic evaluations should begin with a simple, noninvasive, inexpensive test such as serum trypsinogen, to be followed by more complicated testing such as the secretin stimulation test, particularly in those patients with small duct disease. Non-enteric-coated pancreatic enzyme preparations are preferred for the treatment of pain whereas enteric-coated pancreatic enzyme preparations are the drugs of choice for treating steatorrhea. Octreotide may become an important therapy for treating abdominal pain unresponsive to pancreatic enzyme therapy. Endoscopic treatment of the pain of chronic pancreatitis should be used only in highly selected patients and may cause damage to the pancreas. Surgical ductal decompression is appropriate in selected patients.

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“…Some authorities regard the bicarbonate concentration as the most clinically reliable index of exocrine pan creatic function [11], since it is not influenced by technical errors, e.g. poor collection of secretions, as pancreatic secretion volume and bicarbonate output are.…”

Section: Discussionmentioning

confidence: 99%

Exocrine Pancreatic Function in Hepatosplenic Schistosomiasis in the Sudan

Fedail¹,

Baher²,

Aboud³

1985

Digestion

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Exocrine pancreatic function was studied in 36 patients with hepatosplenic schistosomiasis and 31 control subjects. The secretin test and the Lundh test meal were used to assess exocrine pancreas function. Patients with hepatosplenic schistosomiasis had a significantly lower bicarbonate concentration, less than 90 mmol/l in duodenal aspirate, than the control group (p < 0.001). There were statistically insignificant differences in the volume of the duodenal aspirate after the secretin test and in the mean tryptic activity after the Lundh test meal between patients and controls. We conclude that exocrine pancreatic function is impaired with regard to bicarbonate secretion in hepatosplenic schistosomiasis.

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Acute and chronic pancreatitis

Cited by 56 publications

References 88 publications

Biochemical and Molecular Mechanisms of Folate Transport in Rat Pancreas; Interference with Ethanol Ingestion

Biochemical and Molecular Mechanisms of Folate Transport in Rat Pancreas; Interference with Ethanol Ingestion

Update on diagnosis and management of chronic pancreatitis

Exocrine Pancreatic Function in Hepatosplenic Schistosomiasis in the Sudan

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