Acute and Chronic Pancreatitis

Pirola, Romano C.; Lieber, Charles S.

doi:10.1007/978-1-4684-2937-4_11

Cited by 9 publications

(1 citation statement)

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“…Evidence is accumulating that chronic ethanol consumption in man and animals cause damage to a variety of organs. Lipid accumulation, necrosis, and fibrosis, as well as ultrastructural changes of mitochondria and endoplasmic reticulum have been found in liver (Lieber & DeCarli 1977), and some of these changes have been reported for other organs as heart (Ferrans et al 1975;Geller & Rubin 1977), pancreas (Pirola & Lieber 1974), gastrointestinal tract (Lorber er al. 1974), skeletal muscle (Geller & Rubin 1977), and kidneys (Van Thiel et al 1977).…”

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confidence: 87%

Changes in Protein, RNA and DNA Content in Various Rat Organs after Long‐ter m Intake of Ethanol

Smith-Kielland

Merland

1979

Acta Pharmacologica et Toxicologica

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Male Wistar rats were given ethanol (approximately 25% of total caloric intake), while two different control groups were pair‐fed isocaloric amounts of lipids or sucrose. After 7‐10 weeks the following organs were studied: liver, cerebrum, heart, diaphragm, kidneys and testes. In fasted, ethanol treated rats there was a reduction in the hepatic concentration of RNA and the cerebral RNA/DNA ratio, when compared to both control groups, while no effects were found with respect to organ weight and amounts of protein, RNA or DNA in heart, diaphragm, kidneys and testes. When fed, ethanol treated animals were compared to both control groups, no effects on organ weight and composition were found in any tissue studied. Several significant differences were registered in the ethanol group as compared to one control group only, as well as between the two control groups. The consumption of ethanol (25% of total calories) thus caused only minor alterations in gross organ composition. These results also indicate the importance of interpreting with care any apparent effect of ethanol ingestion, unless at least two different control groups have been employed.

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confidence: 87%