Acute and Chronic Low Back Pain

Patrick, Nathan; Emanski, Eric; Knaub, Mark A.

doi:10.1016/j.mcna.2014.03.005

Cited by 163 publications

(98 citation statements)

References 23 publications

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“…[12][13][14][15] In chronic LBP patients, priority is given to support the patients to improve their functionality and reduce the pain rather than trying to provide a cure. 16 Physiotherapy seems to display ambiguous outcomes. The use of modalities (ultrasound, transcutaneous electrical nerve stimulation -TENS, diathermy, and heat/cold) has been investigated, [17][18][19][20][21][22] as well as that of exercise [23][24][25][26] and other manual therapy (MT) treatment techniques 23,[27][28][29] In particular, MT techniques can be divided into two main groups, mobilization and manipulation.…”

Section: Methodsmentioning

confidence: 99%

Spinal mobilization vs conventional physiotherapy in the management of chronic low back pain due to spinal disk degeneration: a randomized controlled trial

Krekoukias

Gelalis

Xenakis

et al. 2016

Journal of Manual & Manipulative Therapy

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Section: Methodsmentioning

confidence: 99%

Spinal mobilization vs conventional physiotherapy in the management of chronic low back pain due to spinal disk degeneration: a randomized controlled trial

Krekoukias

Gelalis

Xenakis

et al. 2016

Journal of Manual & Manipulative Therapy

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“…Low back pain (LBP), which affects over 80% of adults during their lives, is one of the most common clinical problems in the world (Balagué, Mannion, Pellisé, & Cedraschi, ; Patrick, Emanski, & Knaub, ). Currently, LBP is the leading cause of disability globally (Vos et al, ), with high medical expenses and decreased productivity, and which puts a great burden on both the individual and society (Phillips, Ch'ien, Norwood, & Smith, ).…”

Section: Introductionmentioning

confidence: 99%

Development of an in vivo mouse model of discogenic low back pain

Shi

Das

et al. 2018

Journal Cellular Physiology

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Discogenic low back pain (DLBP) is extremely common and costly. Effective treatments are lacking due to DLBP's unknown pathogenesis. Currently, there are no in vivo mouse models of DLBP, which restricts research in this field. The aim of this study was to establish a reliable DLBP model in mouse that captures the pathological changes in the disc and allows longitudinal pain testing. The model was generated by puncturing the mouse lumbar discs (L4/5, L5/6, and L6/S1) and removing the nucleus pulposus using a microscalpel under the microscope. Histology, molecular pathways, and pain-related behaviors were examined. Over 12 weeks post-surgery, animals displayed the mechanical, heat, and cold hyperalgesia along with decreased burrowing and rearing. Histology showed progressive disc degeneration with loss of disc height, nucleus pulposus reduction, proteoglycan depletion, and annular fibrotic disorganization. Immunohistochemistry revealed a substantial increase in inflammatory mediators at 2 and 4 weeks. Nerve growth factor was upregulated from 2 weeks to the end of the experiment. Nerve fiber ingrowth was induced in the injured discs after 4 weeks. Disc-puncture also produced an upregulation of neuropeptides in dorsal root ganglia neurons and an activation of glial cells in the spinal cord dorsal horn. These findings indicate that the cellular and structural changes in discs, as well as peripheral and central nervous system plasticity, paralleled persistent, and robust behavioral pain responses. Therefore, this mouse DLBP model could be used to investigate mechanisms underlying discogenic pain, thereby facilitating effective drug screening and development of treatments for DLBP.

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“…It is estimated that as much as 84% of the worldwide population suffer from LBP at some point in their lifetime, while 10% are chronically disabled [1]. As the second most common cause of doctor visits, LBP has become a major factor affecting quality of life and leads to an enormous socioeconomic burden.…”

Section: Introductionmentioning

confidence: 99%

Tumor necrosis factor-α: a key contributor to intervertebral disc degeneration

Wang¹,

Yu²,

Yan³

et al. 2017

ABBS

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Intervertebral disc (IVD) degeneration (IDD) is the most common cause leading to low back pain (LBP), which is a highly prevalent, costly, and crippling condition worldwide. Current treatments for IDD are limited to treat the symptoms and do not target the pathophysiology. Tumor necrosis factor-α (TNF-α) is one of the most potent pro-inflammatory cytokines and signals through its receptors TNFR1 and TNFR2. TNF-α is highly expressed in degenerative IVD tissues, and it is deeply involved in multiple pathological processes of disc degeneration, including matrix destruction, inflammatory responses, apoptosis, autophagy, and cell proliferation. Importantly, anti-TNF-α therapy has shown promise for mitigating disc degeneration and relieving LBP. In this review, following a brief description of TNF-α signal transduction, we mainly focus on the expression pattern and roles of TNF-α in IDD, and summarize the emerging progress regarding its inhibition as a promising biological therapeutic approach to disc degeneration and associated LBP. A better understanding will help to develop novel TNF-α-centered therapeutic interventions for degenerative disc disease.

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Acute and Chronic Low Back Pain

Cited by 163 publications

References 23 publications

Spinal mobilization vs conventional physiotherapy in the management of chronic low back pain due to spinal disk degeneration: a randomized controlled trial

Spinal mobilization vs conventional physiotherapy in the management of chronic low back pain due to spinal disk degeneration: a randomized controlled trial

Development of an in vivo mouse model of discogenic low back pain

Tumor necrosis factor-α: a key contributor to intervertebral disc degeneration

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Acute and Chronic Low Back Pain

Cited by 163 publications

References 23 publications

Spinal mobilization vs conventional physiotherapy in the management of chronic low back pain due to spinal disk degeneration: a randomized controlled trial

Spinal mobilization vs conventional physiotherapy in the management of chronic low back pain due to spinal disk degeneration: a randomized controlled trial

Development of an in vivo mouse model of discogenic low back pain

Tumor necrosis factor-&alpha;: a key contributor to intervertebral disc degeneration

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Tumor necrosis factor-α: a key contributor to intervertebral disc degeneration