Acute and chronic effects of continuous positive airway pressure therapy on left ventricular systolic and diastolic function in patients with obstructive sleep apnea and congestive heart failure

The impact of positive airway pressure on cardiac status and clinical outcomes in patients with advanced heart failure and sleep-disordered breathing: a preliminary report

“…In patients with HF and OSA, CPAP has been regarded as an effective therapy not only for OSA but also for the underlying HF in short-term investigations that showed improvement of LVEF, NYHA class, and quality of life [37][38][39][40]. APAP which is an alternative mode of PAP application in OSA patients, has been found to be equally effective to CPAP and has been linked with enhanced compliance to treatment [15].…”

Effects of Auto-Servo Ventilation on Patients with Sleep-Disordered Breathing, Stable Systolic Heart Failure and Concomitant Diastolic Dysfunction: Subanalysis of a Randomized Controlled Trial

“…This is supported by the finding that trials with a treatment duration ≤6 weeks could not show a significant effect of ASV on LVEF [17,18], whereas studies with a treatment duration >6 weeks did [36,38]. This time dependency was also found in trials evaluating acute versus chronic effects of an SDB-specific therapy: so LVEF was even significantly reduced after acute initiation of CPAP treatment and only improved with ongoing therapy eventually leading to a significant gain of LVEF in the longer term [44,45]. Secondly, since treatment effects on LVEF are generally rather low (as seen by a 2.2 ± 5.4% improvement in LVEF in the 258 patients evaluated by Bradley et al [40]), the cohort size under investigation might also be of relevance, and larger cohorts need to be evaluated to finally judge the impact of ASV therapy on LVEF.…”

Terapias ventilatorias domiciliarias en el síndrome de apnea-hipopnea del sueño

“…Algunos estudios han demostrado que la CPAP reduce el IAH, mejora la fracción de eyección del ventrículo izquierdo y reduce la actividad simpática en la insuficiencia cardiaca [64][65][66] . Sin embargo, el único ensayo aleatorizado y prospectivo importante hasta la fecha es el Canadian Positive Airway Pressure 67 , que comparó en pacientes con insuficiencia cardiaca y TRS, asignados al azar, la terapia de CPAP frente a la atención médica habitual.…”