1996
DOI: 10.2337/diabetes.45.5.699
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Acute and chronic effects of insulin on leptin production in humans: Studies in vivo and in vitro

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Cited by 278 publications
(252 citation statements)
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“…Together, these findings suggested that relatively large increases in serum insulin levels (Ͼ 200 pM) were needed for relatively long periods of time (Ͼ 24 h) before serum leptin levels rose significantly. These results are in accord with reports by several groups, who, with one exception, all failed to find effects of acute (up to 5 h) hyperinsulinemia on leptin levels (10)(11)(12)(13)(14)(15)(16). The sole exception, a study by Utriainen et al (16), reported an ‫ف‬ 50% increase in serum leptin after 4 h of unphysiologic high insulin levels ‫ف(‬ 2,800 pM).…”
Section: Discussionsupporting
confidence: 89%
See 1 more Smart Citation
“…Together, these findings suggested that relatively large increases in serum insulin levels (Ͼ 200 pM) were needed for relatively long periods of time (Ͼ 24 h) before serum leptin levels rose significantly. These results are in accord with reports by several groups, who, with one exception, all failed to find effects of acute (up to 5 h) hyperinsulinemia on leptin levels (10)(11)(12)(13)(14)(15)(16). The sole exception, a study by Utriainen et al (16), reported an ‫ف‬ 50% increase in serum leptin after 4 h of unphysiologic high insulin levels ‫ف(‬ 2,800 pM).…”
Section: Discussionsupporting
confidence: 89%
“…Possible causes for the precipitous decrease in leptin during fasting include changes in serum insulin and/or glucose concentrations. Insulin, because of its close relationship to appetite and body weight control (9), has been scrutinized by several groups (10)(11)(12)(13)(14)(15)(16). All but one (16) found no acute (up to 5 h) effects of hyperinsulinemia on serum leptin concentrations.…”
Section: Introductionmentioning
confidence: 99%
“…Third, the levels of adiponectin were very low in the preovulatory follicular fluid consistent with absent or undetectable expression of this protein in human granulosa cells [20]. Lastly, it is well established that insulin can stimulate leptin production both in vivo and in vitro [13], whereas adiponectin may potentiate insulin sensitivity at the tissue level but not necessarily affect its expression [2,22]. This is consistent with our observation that FF leptin and the L:A ratio positively correlated with FF insulin, while adiponectin and insulin were indirectly associated.…”
Section: Discussionmentioning
confidence: 67%
“…Noteworthy in the present study is the finding that only serum T3 levels were independently correlated with plasma leptin levels (r ¼ 0.928, P < 0.0001) in multiple regression analyses after adjustment of the time course and BMI, raising the possibility that T3 levels during LCD may play a crucial role in regulating plasma leptin levels. However, this does not exclude the possibility that insulin and NEFA may affect plasma leptin levels (Kolaczynski et al, 1996c;Rentsch & Chiesi, 1996).…”
Section: Clinical Implications Of Leptinmentioning
confidence: 93%
“…Several studies have demonstrated that the leptin gene expression is positively regulated by insulin both in vivo (Saladin et al, 1995;Kolaczynski et al, 1996c) and in vitro (Kolaczynski et al, 1996c;Leroy et al, 1996). Plasma leptin levels decrease after fasting and increase by refeeding in humans (Kolaczynski et al, 1996a,b;Boden et al, 1996;Dubuc et al, 1998;Geldszus et al, 1996;Wadden et al, 1998) and rodents (Frederich et al, 1995), which parallels the change in plasma insulin levels (Kolaczynski et al, 1996b).…”
Section: Clinical Implications Of Leptinmentioning
confidence: 97%