Acute aluminum phosphide poisoning: The menace of phosphine exposure

Yadav, Deepak; Bhattacharyya, Rajasri; Banerjee, Dibyajyoti

doi:10.1016/j.cca.2021.05.026

Cited by 28 publications

(9 citation statements)

References 79 publications

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“…There is no specific antidote for AlP poisoning; so many substances have been proposed recently to achieve a better outcome for AlP cases (Yadav et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Ameliorative Effects of Erdosteine and Exogenous Reduced Nicotinamide Adenine Dinucleotide Phosphate on Aluminium Phosphide Induced Cardiotoxicity in Adult Albino Rats.

Ali

elbadawy

Metwally

et al. 2022

Mansoura Journal of Forensic Medicine and Clinical Toxicology

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The present study was performed to determine the possible protective effects of erdosteine and exogenous reduced nicotinamide adenine dinucleotide phosphate (NADPH) against cardiotoxicity produced by aluminium phosphide (AlP) via measurement of serum cardiac markers and assessment of cardiomyocyte viability and apoptosis by flow cytometry analysis. Fifty-four adult albino rats were divided into seven groups as follows; four control groups (negative control, solvent control, erdosteine control, NADPH control), AlP group (12 mg/kg) orally, AlP + erdosteine (150 mg/kg) orally, AlP + NADPH (16 mg/kg) intravenously. After 8 hours, blood samples were collected from the retro-orbital plexus for analysis of serum cardiac markers, and then the chest and abdomen were carefully incised to remove the hearts for flow cytometry analysis and histopathological examination. Results revealed that AlP poisoning caused an increase in serum cardiac markers (LDH, cTnI) with a marked decrease in the viability of cardiac myocytes and a marked increase in the percent of apoptotic cardiac myocytes. Co-administration of erdosteine with AlP slightly improved serum cardiac markers and cardiomyocyte viability, with a slight decrease in the percent of apoptosis. Coadministration of NADPH with AlP showed marked improvement in serum cardiac markers, a marked increase in myocardial cell viability, and a marked decrease in the percent of apoptotic myocytes. These findings were confirmed by histopathological examination of heart tissues from each group. From the previous data, it can be concluded that administration of exogenous NADPH intravenously may be a promising antidote for AlP toxicity.

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“…There is no specific antidote for AlP poisoning; so many substances have been proposed recently to achieve a better outcome for AlP cases (Yadav et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Ameliorative Effects of Erdosteine and Exogenous Reduced Nicotinamide Adenine Dinucleotide Phosphate on Aluminium Phosphide Induced Cardiotoxicity in Adult Albino Rats.

Ali

elbadawy

Metwally

et al. 2022

Mansoura Journal of Forensic Medicine and Clinical Toxicology

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“…We are continuously getting exposed to several chemicals, and such exposure is definitely having effect on mitochondrial function. As an example, aluminum phosphide (rice or wheat pill) which induces phosphine exposure acts as mitochondrial poison (Yadav et al 2021). We do not know entirely with which mitochondrial proteins it interacts.…”

Section: Whether the Mitoproteome Database Represents Exclusively Mit...mentioning

confidence: 99%

Sorting of exclusive mitochondrial proteins from the Mitoproteome database

et al. 2022

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World Wide Web and scientific literature record information regarding several organelles and mitochondria is not an exception. However, currently mitochondrial databases also provide information about non-mitochondrial proteins. As on date, there is no way to know the exclusive mitochondrial proteins. It is crucial to know the exclusively mitochondrial proteins, present in mitochondria but absent elsewhere. In this work, by analysis of available databases, we have provided a list of exclusively mitochondrial proteins known as on date.

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“…Persistent epigastric burning was seen in one patient presumably due to thermal injury that may necessitate more supportive treatment of the gastric mucosa in the acute phase. Some herbal oils and extracts have been proposed [2] but their effectiveness remains unclear. In this study, only one patient was re-admitted because of a complaint about shortness of breath and the diagnosis of pneumonia or pleural effusion.…”

Section: Treatmentmentioning

confidence: 99%

“…Metal phosphides (aluminum, zinc, magnesium, and calcium) have long been accepted as rodenticides and pesticides across the world [1]. Low cost, high strength in killing harmful insects and rodents, leaving no toxic residues, and no adverse consequences on the health of grains are factors contributing to the extensive application of metal phosphides [2]. These compounds of phosphorus are widely utilized in all stages of transportation of cereals by ships or trains (for example) and their storage in silos.…”

Section: Introductionmentioning

confidence: 99%

The Treatment Results in Patients with Aluminum Phosphide Toxicity Admitted to Razi Hospital in Ahvaz

Jamshidi¹,

Tehrani²,

Ghorbani³

2021

PJMHS

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Introduction: Aluminum phosphide (ALP), locally known as "Rice Tablet", is a cheap and powerful pesticide used frequently to protect cereals. Cases of ALP toxicity have grown dramatically in recent decades by using it for suicide purposes. Treatment of ALP toxicity is largely supported by various remedies as there is no specific antidote. This study deals with the epidemiology of ALP toxicity in Khuzestan (Iran) and assesses the clinical and paraclinical manifestations, as well as the results of various treatments during the last 12 years. The study further examines the next suicidal intentions and subsequent complications of poisoning with ALP. Methodology: The records of all patients with ALP toxicity admitted to Razi Hospital in Ahvaz from 2006 to 2017 were reviewed within a retrospective study. Epidemiological and demographic information, clinical and paraclinical manifestations, and the results of various treatments were extracted. Data on the subsequent complications and the next suicidal intentions in those who have survived a suicide attempt were gathered and analyzed. Results: Of the 48 patients studied, 50% were male and the mean age was 29.33±10.45. Most of the toxicities were orally and with the intention of suicide in Ahvaz and Andimeshk. A total of 71.42% of the dead have been carried to this center. The majority of cases were reported from urban areas and in August and during summer. The most prevalent clinical signs were loss of consciousness, nausea, and vomiting. There were some differences in the experimental and EKG results. A meaningful correlation was observed between the administration and/or consumption of ranitidine, NAC, and intravenous sodium bicarbonate with treatment outcomes. Only one case of reattempt to suicide has been reported, and hematuria, ascites, and pleural effusion were widely visible in survivors. Conclusion: On-call counseling may decrease the rate of mortality in dispatching patients. Clinical and paraclinical manifestations can be useful in the diagnosis or prognosis. Patients' follow-up, actions to enhance public awareness, restrictions on the distribution of ALP, and availability of alternative substances can be helpful to diminish cases of ALP toxicity and/or death. Keywords: Aluminum phosphide (ALP), Rice tablets, Poisoning, Khuzestan

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Acute aluminum phosphide poisoning: The menace of phosphine exposure

Cited by 28 publications

References 79 publications

Ameliorative Effects of Erdosteine and Exogenous Reduced Nicotinamide Adenine Dinucleotide Phosphate on Aluminium Phosphide Induced Cardiotoxicity in Adult Albino Rats.

Ameliorative Effects of Erdosteine and Exogenous Reduced Nicotinamide Adenine Dinucleotide Phosphate on Aluminium Phosphide Induced Cardiotoxicity in Adult Albino Rats.

Sorting of exclusive mitochondrial proteins from the Mitoproteome database

The Treatment Results in Patients with Aluminum Phosphide Toxicity Admitted to Razi Hospital in Ahvaz

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