Acute airway obstruction due to oedema of the larynx following antimony therapy in mucosal leishmaniasis

Costa, J. M. L.; Netto, Eduardo Martins; Marsden, Philip D.

doi:10.1590/s0037-86821986000200012

Cited by 7 publications

(5 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Additionally, there have been recently reported cases of cerebellar ataxia induced by pentavalent antimonial drug (Khalil et al 2006), and sleep disorders are a common occurrence in neurodegenerative disorders such as cerebellar ataxia (Pedroso et al 2011; Velázquez-Pérez et al 2011). Edema of the upper airway is involved in the pathogenesis of OSA (Dempsey et al 2010), and acute airway obstruction due to edema of the larynx with progressive difficulty in breathing has been reported after antimony therapy in mucosal leishmaniasis (Costa et al 1986). …”

Section: Discussionmentioning

confidence: 99%

Antimony and sleep-related disorders: NHANES 2005–2008

Scinicariello

Buser

Feroe

et al. 2017

Environmental Research

View full text Add to dashboard Cite

Background Antimony is used as a flame-retardant in textiles and plastics, in semiconductors, pewter, and as pigments in paints, lacquers, glass and pottery. Subacute or chronic antimony poisoning has been reported to cause sleeplessness. The prevalence of short sleep duration (<7 hours/night) has been reported to be 37.1% in the general US population, and obstructive sleep apnea (OSA) affects 12–28 million US adults. Insufficient sleep and OSA have been linked to the development of several chronic conditions including diabetes, cardiovascular disease, obesity and depression, conditions that pose serious public health threats. Objective To investigate whether there is an association between antimony exposure and sleep-related disorders in the US adult population using the National Health and Nutrition Examination Survey (NHANES) 2005–2008. Methods We performed multivariate logistic regression to analyze the association of urinary antimony with several sleep disorders, including insufficient sleep and OSA, in adult (ages 20 years and older) participants of NHANES 2005–2008 (n=2654). Result We found that participants with higher urinary antimony levels had higher odds to experience insufficient sleep (≤ 6 hours/night) (OR 1.73; 95%CI; 1.04, 2.91) as well as higher odds to have increased sleep onset latency (>30 minutes/night). Furthermore, we found that higher urinary antimony levels in participants were associated with OSA (OR 1.57; 95%CI; 1.05, 2.34), sleep problems, and day-time sleepiness. Conclusion In this study, we found that urinary antimony was associated with higher odds to have insufficient sleep and OSA. Because of the public health implications of sleep disorders, further studies, especially a prospective cohort study, are warranted to evaluate the association between antimony exposure and sleep-related disorders.

show abstract

Section: Discussionmentioning

confidence: 99%

Antimony and sleep-related disorders: NHANES 2005–2008

Scinicariello

Buser

Feroe

et al. 2017

Environmental Research

View full text Add to dashboard Cite

show abstract

“…Alguns autores consideram que para caracterizar esse quadro, devem ser observadas mais de vinte lesões (Vieira et al, 2002). Na LTA, esta forma de apresentação clínica está associada à infecção por L. braziliensis, L. amazonensis, L. guyanensis e L. panamensis (Vieira-Gonçalves et al, 2008;Costa et al, 1986;Couppié et al, 2004;Rincón et al, 2009). Afeta predominantemente o adulto do sexo masculino, porém há casos descritos em mulheres e crianças (Costa et al, 1986;Rincón et al, 2009).…”

Section: Leishmaniose Disseminadaunclassified

“…Sintomas constitucionais como febre, astenia e mal-estar estão presentes em alguns pacientes no início da disseminação das lesões. A mucosa das vias aéreas superiores pode estar acometida em qualquer fase da doença, precedendo o quadro cutâneo ou mesmo após terapia, em frequência variável, na LD causada por L. braziliensis ou L. amazonensis Machado et al, 2011;Costa et al, 1986). Por essa razão, a denominação leishmaniose disseminada é mais apropriada do que leishmaniose cutânea disseminada.…”

Section: Leishmaniose Disseminadaunclassified

“…O tratamento da LM deve ser iniciado preferencialmente em regime de internação hospitalar, pois o processo inflamatório das lesões infiltrativas, edematosas ou ulceradas na mucosa das vias aéreas superiores pode se exacerbar, levando à obstrução e necessidade de traqueostomia de urgência. Tal fenômeno foi interpretado como uma reação semelhante à de Jarisch-Herxheimer (Costa, Netto & Marsden, 1986). Coadjuvantes à terapia com antimoniais, como o emprego concomitante de pentoxifilina, um inibidor de TNF-α (Lessa et al, 2001), foram empregados com o objetivo de modular negativamente a reação inflamatória provocada pela resposta celular do tipo 1 que é exacerbada nessa forma clínica.…”

Section: Leishmaniose Mucosaunclassified

See 1 more Smart Citation

Leishmanioses do continente americano

Conceição-Silva¹,

Alves²

2014

View full text Add to dashboard Cite

show abstract

“…3,5 In parallel, histopathologic analysis or anti-Leishmania serology are used for diagnosis of ML. Considering that ML patients do not undergo spontaneous cure and present fatal outcome if left untreated and that ML treatment requires a longer drug regiment than CL, [6][7][8] a proper diagnosis of this particular clinical manifestation is of utmost importance.…”

mentioning

confidence: 99%