2010
DOI: 10.2214/ajr.09.3099
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Acute Adverse Reactions to Gadopentetate Dimeglumine and Gadobenate Dimeglumine: Experience With 32,659 Injections

Abstract: The rates of acute adverse reactions to gadopentetate dimeglumine and gadobenate dimeglumine were 0.14% and 0.28%, respectively. The overall adverse reaction rate was 0.16% in our patient sample. Direct comparison of adverse reaction rates of the two agents was not possible because of the retrospective uncontrolled study design.

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Cited by 83 publications
(69 citation statements)
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“…Our results are completely in line with the recently published data extracted from the Euro-CMR study in which 30 acute adverse reactions (0.17%) occurred in a large cohort of 17,767 doses administered [31]. Similar findings were reported in larger studies analyzing the incidence of gadolinium-related contrast media reactions reporting event rates ranging between 0.04 and 2.2% [32][33][34].…”
Section: Safety Profilesupporting
confidence: 91%
“…Our results are completely in line with the recently published data extracted from the Euro-CMR study in which 30 acute adverse reactions (0.17%) occurred in a large cohort of 17,767 doses administered [31]. Similar findings were reported in larger studies analyzing the incidence of gadolinium-related contrast media reactions reporting event rates ranging between 0.04 and 2.2% [32][33][34].…”
Section: Safety Profilesupporting
confidence: 91%
“…However, the use of any contrast medium carries a potential risk and, in the case of gadolinium-based media, nephrotoxicity and allergic reactions can result [31,32], although they are infrequent and usually mild.…”
Section: Discussionmentioning
confidence: 99%
“…On the basis of published data, rates of adverse reactions following GBCA administration range between 0.03% and 2.4%. 56 Adverse drug reactions fall into 2 major categories. The first includes reactions that can occur in any patient, such as drug overdose and drug interactions; the second includes reactions that are restricted to susceptible patients, such as drug toxicity/augmented effects (ie, drug idiosyncrasy or reduced tolerance) and hypersensitivity reactions that are either allergic or pseudoallergic in nature.…”
Section: Adverse Reactionsmentioning
confidence: 99%
“…56,76,78 After experience is accumulated by using a given product, previously noteworthy reactions are perceived as being predictable and less noteworthy and, therefore, may be reported less frequently. 56,76,78 Thus, the Weber effect is characterized by a transient increase in adverse event reporting that tends to peak in the second year following introduction of a new agent, with a subsequent return to the original baseline reaction rate observed before the introduction of the new agent. 76 Such an effect was recently reported with GBCAs by Davenport et al, 79 who described the impact of an abrupt switch from Magnevist to MultiHance on the incidence of immediate allergic-type adverse events.…”
Section: 77mentioning
confidence: 99%
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