Acute administration of S-adenosyl-L-methionine in the therapy of alcoholic hepatitis

Olivera, M

doi:10.1016/0270-9139(94)90615-7

Cited by 1 publication

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“…Of interest, sphingosine kinase (SPHK), the enzyme that catalyzes the phosphorylation of sphingosine, is activated by growth and survival factors, including platelet-derived growth factor (PDGF), serum [13], nerve growth factor [14], and vitamin D3 [15], as well as activation of protein kinase C [16], resulting in increased intracellular levels of SPP. Abundant evidence indicates that SPP promotes cell growth, proliferation, and resistance to apoptosis [17,18].…”

Section: Introductionmentioning

confidence: 99%

Stimulation of nuclear sphingosine kinase activity by platelet‐derived growth factor

Kleuser

Maceyka

Milstien³

et al. 2001

FEBS Letters

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Subcellular fractionation revealed that a significant fraction of total sphingosine kinase, the enzyme that phosphorylates sphingosine to form the bioactive lipid metabolite sphingosine-1-phosphate, resides in the nuclei of Swiss 3T3 cells, localized to both the nuclear envelope and the nucleoplasm. Platelet-derived growth factor, in addition to rapidly stimulating cytosolic sphingosine kinase, also induced a large increase in nucleoplasm-associated activity after 12^24 h that correlated with progression of cells to the S-phase of the cell cycle and translocation of sphingosine kinase^green fluorescent protein fusion protein to the nuclear envelope. Our results add sphingosine kinase to the growing list of lipid-metabolizing enzymes associated with the nucleus, and suggest that sphingosine-1-phosphate may also play a role in signal transduction in the nucleus. ß 2001 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.

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Section: Introductionmentioning

confidence: 99%