Acute acetaminophen toxicity in adults

Alterations in circadian rhythms aggravate Acetaminophen-induced liver injury in mice by influencing Acetaminophen metabolization and increasing intestinal permeability

“…According to previous studies, the peak blood concentrations of APAP and its related metabolites were reached around 1 hour after APAP administration in both mice and rats [ 21 , 22 ]. When ingested by human adults, APAP is rapidly absorbed from the gastrointestinal tract, and the peak concentration of APAP is reached 30 to 60 minutes after ingestion [ 23 ]. Therefore, we measured APAP levels and the metabolites in the serum of mice 1 h after drug administration.…”

Egyptian perspectives on potential risk of paracetamol/acetaminophen-induced toxicities: Lessons learnt during COVID-19 pandemic

“…This disagrees with Hornsby et al [38] study at Alabama assessing patient knowledge about acetaminophen which showed that 46% knew that “acetaminophen” and “Tylenol” were synonym [38] . Thus, our result is considered an alarming sign as unaware patients of the alternative names of acetaminophen and the different over-the-counter and prescription medications containing paracetamol/acetaminophen are potentially at risk of developing paracetamol-induced toxicities [12] , [15] , [39] , [40] . This explanation also agrees with our results that many of our participants were also not knowledgeable about the cautious administration of paracetamol with other drugs.…”

“…This unrecognition of early signs of paracetamol could hinder the effective timely treatment. Accordingly, diverting the patients' attention towards the existence of warning signs could be helpful to prevent significant morbidity and mortality [12] , [15] , [48] .…”

“…Paracetamol is one of the most effective and most widely used analgesics and antipyretics worldwide. It exists both in the form of a single component or multi-component preparations, also as OTC and prescription formulations [11] , [12] .…”

Catatonic syndrome during COVID-19 - a case study

“…(ASPAT) dobie hospitalizacji, co w świetle dostępnej literatury zmniejsza prawdopodobieństwo faktycznego zatrucia acetaminofenem, gdyż największe stężenie badanych parametrów powinno tutaj wystąpić w ciągu 72-96 godzin od spożycia toksycznej dawki, natomiast maksymalnie do 14 dni od tego momentu powinno ulec normalizacji, czego w opisywanym przypadku nie zaobserwowano (tab. 1) [29]. W tym miejscu należy zaznaczyć, że odchylenia od norm w badaniach laboratoryjnych zasadniczo nie są specyficzne dla żadnej z dyskutowanych przyczyn objawów u pacjenta.…”