Acute acalculous cholecystitis during zika virus infection in an immunocompromised patient

Ono, Suzanne Kioko; Bassit, Leda; Vaisberg, Victor Van; Alves, Venâncio Avancini Ferreira; Caldini, Élia Garcia; Herman, Brian D.; Shabman, Reed S.; Fedorova, Nadia; Paranaguá‐Vezozzo, Denise Cerqueira; Sampaio, Caroline Torres; Lages, Rafael Bandeira; Andraus, Wellington; Schinazi, Raymond F.; Carrilho, Flair José

doi:10.1002/hep.29682

Cited by 6 publications

(6 citation statements)

References 7 publications

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“…For this reason, the EM in our report was done by a professor with more than 30 years of experience in ultrastructural analysis. 3 , 4 Figure 3B in our case report 2 does show a rough endoplasmic reticulum, as suggested by Dittmayer and colleagues, but it also shows a particular aspect of viral particle assembly (a section through a spherical cluster of viral nucleocapsids apposed on the membrane of the rough endoplasmic reticulum), which is probably a viral translation centre. 5 …”

supporting

confidence: 80%

Using EM data to understand COVID-19 pathophysiology

et al. 2021

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supporting

confidence: 80%

Using EM data to understand COVID-19 pathophysiology

et al. 2021

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Section: Acalculous Cholecystitis In Patients Without Underlying Critical Illnessmentioning

confidence: 82%

“…Similar to the other viruses mentioned above, Zika virus was found to cause microangiopathy of the gallbladder vessels in an immunocompromised patient[ 23 ]. Ono et al [ 23 ] used polymerase chain reaction to detect the virus in the gallbladder tissue and in the bile. Furthermore, through electron microscopy, they identified flavivirus-like particles both in intracellular and extracellular compartments of the vessel.…”

Section: Acalculous Cholecystitis In Patients Without Underlying Critical Illnessmentioning

confidence: 82%

Acute acalculous cholecystitis due to infectious causes

Markaki¹,

Konsoula²,

Markaki³

et al. 2021

WJCC

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Acute acalculous cholecystitis (AAC) is an inflammation of the gallbladder not associated with the presence of gallstones. It usually occurs in critically ill patients but it has also been implicated as a cause of cholecystitis in previously healthy individuals. In this subgroup of patients, infectious causes comprise the primary etiology. We, herein, discuss the pathophysiological mechanisms involved in AAC, focusing on the infectious causes. AAC associated with critical medical conditions is caused by bile stasis and gallbladder ischemia. Several mechanisms are reported to be involved in AAC in patients without underlying critical illness including direct invasion of the gallbladder epithelial cells, gallbladder vasculitis, obstruction of the biliary tree, and sequestration. We emphasize that multiple pathogenic mechanisms may concurrently contribute to the development of AAC in varying degrees. Awareness of the implicated pathogens is essential since it will allow a more focused examination of the histopathological specimens. In conclusion, additional research and a high degree of clinical suspicion are needed to clarify the complex spectrum of mechanisms that are involved in the pathogenesis of AAC.

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“…Several viruses have been reported to affect the gallbladder through immune-mediated necrotizing vasculitis. Antibody dependent cell-mediated cytotoxicity or complement-dependent cytotoxicity are considered possible mechanisms, while others [ 63 , 64 , 65 , 66 ] have stated that AAC can be caused by the destruction of the endothelium, causing the extravasation of fluid and leading to gallbladder wall edema or nonocclusive thrombosis [ 67 , 68 ].…”

Section: Aac Pathogenesismentioning

confidence: 99%

Acalculous Cholecystitis in COVID-19 Patients: A Narrative Review

Thomaidou,

Karlafti,

Didagelos

et al. 2024

Viruses

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Acute acalculous cholecystitis (AAC) represents cholecystitis without gallstones, occurring in approximately 5–10% of all cases of acute cholecystitis in adults. Several risk factors have been recognized, while infectious diseases can be a cause of cholecystitis in otherwise healthy people. Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has spread worldwide, leading to an unprecedented pandemic. The virus enters cells through the binding of the spike protein to angiotensin-converting enzyme 2 (ACE2) receptors expressed in many human tissues, including the epithelial cells of the gastrointestinal (GI) tract, and this explains the symptoms emanating from the digestive system. Acute cholecystitis has been reported in patients with COVID-19. The purpose of this review is to provide a detailed analysis of the current literature on the pathogenesis, diagnosis, management, and outcomes of AAC in patients with COVID-19.

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Acute acalculous cholecystitis during zika virus infection in an immunocompromised patient

Cited by 6 publications

References 7 publications

Using EM data to understand COVID-19 pathophysiology

Using EM data to understand COVID-19 pathophysiology

Acute acalculous cholecystitis due to infectious causes

Acalculous Cholecystitis in COVID-19 Patients: A Narrative Review

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