Acupuncture with Long Dan Xie Gan Tang to Treat 36 Cases of Chronic Pelvic Inflammation

Jin, Yuhao

doi:10.1055/s-2006-955999

Cited by 4 publications

(5 citation statements)

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“…According to recent clinical and preclinical studies, the LDXGT formulation and other Chinese herbal medicines exert potential hepatoprotective, immunomodulatory and antitumor effects. Therefore, the combination of sorafenib with the LDXGT formulation has been thought to exert a synergistic effect on chronic hepatitis and may even be beneficial for HCC [ 21 , 22 , 23 , 24 ]. However, the herb-drug interaction is limited and under-evaluated.…”

Section: Discussionmentioning

confidence: 99%

“…The traditional Chinese prescription LDXGT is composed of ten important plants: Radix Gentianae, Radix Scutellariae, Fructus Gardeniae, Rhizoma Alismatis, Caulis Hocquartiae, Semen Plantaginis, Radix Angelicae Sinensis, Radix Rehmanniae, Radix Bupleuri and Radix Glycyrrhizae. LDXGT is a famous Chinese prescription and is widely used in Chinese medicine due to its anti-inflammatory, anti-infection, anti-bacterial, anti-allergy, hepatoprotective, cholagogue and immunostimulant functions [ 21 , 22 , 23 , 24 ]. The herbal drugs contained in this formula are reported to have multiple effects, such as anti-hepatitis B virus or other virus ( Scutellaria baicalensis , Bupleurum chinense , Glycyrrhiza uralensis and Gentiana scabra ), anti-inflammatory ( Gardenia jasminoides ) and anti-oxidant or immunomodulatory effects ( Alisma plantago , Plantago asiatica , Akebia trifoliate , Rehmannia glutinosa , Angelica sinensis , Bupleurum chinense and Glycyrrhiza uralensis ) [ 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 ].…”

Section: Introductionmentioning

confidence: 99%

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Herb-Drug Interaction between the Traditional Hepatoprotective Formulation and Sorafenib on Hepatotoxicity, Histopathology and Pharmacokinetics in Rats

Ting

Cheng²,

Tsai

2017

Molecules

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Sorafenib has been used as a standard therapy for advanced hepatocellular carcinoma (HCC). In Asia, patients with HCC are potentially treated with the combination of sorafenib and Chinese herbal medicines to improve the efficiency and reduce the side effects of sorafenib. However, limited information about the herb-drug interactions is available. We hypothesize that the Chinese herbal medicine may exert hepatoprotective effects on the sorafenib-treated group. The aim of this study is to investigate the pharmacokinetic mechanism of drug-drug interactions of sorafenib including interacting with hepatoprotective formulation, Long-Dan-Xie-Gan-Tang formulation (LDXGT) and with two cytochrome P450 3A4 (CYP3A4) inhibitors, grapefruit juice and ketoconazole. Liver enzyme levels and histopathology of liver slices were used to evaluate sorafenib-induced hepatotoxicity and the potential hepatoprotective effects of the LDXGT formulation on subjects treated with the combination of sorafenib and the herbal medicine. In this study, a validated HPLC-photodiode array analytical system was developed for the pharmacokinetic study of sorafenib in rats. As the result of the pharmacokinetic data, pretreatment with the LDXGT formulation did not significantly interact with sorafenib compared with sorafenib oral administration alone. Furthermore, grapefruit juice and ketoconazole did not significantly affect sorafenib metabolism. Furthermore, pretreatment with variable, single or repeat doses of the LDXGT formulation did not suppress or exacerbate the sorafenib-induced hepatotoxicity and histopathological alterations. According to these results, the LDXGT formulation is safe, but has no beneficial effects on sorafenib-induced hepatotoxicity. A detailed clinical trial should be performed to further evaluate the efficacy or adverse effects of the LDXGT formulation in combination with sorafenib in humans.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Herb-Drug Interaction between the Traditional Hepatoprotective Formulation and Sorafenib on Hepatotoxicity, Histopathology and Pharmacokinetics in Rats

Ting

Cheng²,

Tsai

2017

Molecules

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“…In differentiating the syndromes, attention should be paid to the constitution of the Deficiency and Excess. Acupuncture, moxibustion and the ancient recipe Long Dan Xie Gan Tang used together have been found to enhance the therapeutic effects on chronic pelvic inflammation, in which, reducing method was applied at ZhongJi (CV-3), Guanyuan (CV-4) and Zigong (EX-CA-1), reinforcing method at Zusanli (ST-36) Sanyinjiao (SP-6) and Diji (SP-8) and indirect moxibustion with 3 medicated cakes was performed at Shenque (CV-8) (Jin, 2004). Zhao's study showed that vitamin K 3 acupoint injection at Sanyinjiao(SP-6) is an effective and safe measure for treating patients with primary dysmenorrhea, and it has also some effects in relieving pelvic pain caused by chronic pelvic inflammatory disease and endometriosis (Zhao et al, 2003).…”

Section: Chronic Pelvic Inflammationmentioning

confidence: 99%

Treating gynaecological disorders with traditional Chinese medicine: a review

Zhou

Qu²

2010

Afr. J. Trad. Compl. Alt. Med.

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Traditional Chinese Medicine (TCM) has significant advantages in treating gynaecological disorders. The paper has provided a brief introduction on the current progress of treating some gynaecological disorders including endometriosis, infertility, dysmenorrhea, abnormal uterine bleeding, premenstrual syndrome, menopausal syndrome, uterine fibroids, chronic pelvic inflammation, polycystic ovarian syndrome (PCOS), cervicitis and vaginitis with Chinese Herbal Medicine (CHM) and acupuncture. The use of TCM in the field of assisted reproductive techniques (ART) has also been included in the review. In addition, thirty-two commonly used Chinese medicinal formulas in treating gynaecological disorders have been introduced.

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“…This herbal prescription is reported to possess hepatoprotective, anti-inflammation, antioxidation, anti-cancer, and immunomodulation activities, and is commonly used in the clinic to treat functional dyspepsia, postmenopausal women with baicalensis, Gardenia jasminoides, Alisma plantago, Plantago asiatica, Akebia trifoliate, Rhemannia glutinosa, Angelica sinensis, Bupleurum chinense and Glycyrrhiza uralensis. Recently, much pharmacological research has shown that Long-Dan-Xie-Gan-Tang has potent anti-inflammation, anti-oxidation, immune modulation, anti-herpetic virus, and anti-HBV properties (24,25). It is reported that Long-Dan-Xie-Gan-Tang is the most commonly prescribed Chinese herbal formula for subjects with CHB in Taiwan (25).…”

Section: Xiao-yao-sanmentioning

confidence: 99%

Traditional Chinese medicine and related active compounds: A review of their role on hepatitis B virus infection

et al. 2013

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Since the significant public health hazard of Hepatitis B virus (HBV) infection and obvious drug resistance and dose-dependent side effects for common antiviral agents (e.g., interferon α, lamivudine, and adefovir), continuous development of agents to treat HBV infection is urgently needed. Traditional Chinese medicine (TCM) is an established segment of the health care system in China. Currently, it is widely used for chronic hepatitis B (CHB) in China and many parts of the world. Over a long period of time in clinical practice and in basic research progress, the effectiveness and beneficial contribution of TCM on CHB have been gradually known and confirmed. Based upon our review of related papers and because of our prior knowledge and experience, we have selected some Chinese medicines, including Chinese herbal formulas (e.g., Xiao-Chai-Hu-Tang, Xiao-Yao-San, and Long-Dan-Xie-Gan-Tang), single herbs (e.g., Phyllanthus niruri, Radix astragali, Polygonum cuspidatum, Rheum palmatum, and Salvia miltiorrhiza) and related active compounds (e.g., wogonin, artesunate, saikosaponin, astragaloside IV, and chrysophanol 8-O-beta-Dglucoside) and Chinese medicine preparations (e.g., silymarin, silibinin, kushenin, and cinobufacini), which seem effective and worthy of additional and indepth study in treating CHB, and we have given them a brief review. We conclude that these Chinese herbal medicines exhibit significant anti-HBV activities with improved liver function, and enhanced HBeAg and HBsAg sero-conversion rates as well as HBV DNA clearance rates in HepG2 2.2.15 cells, DHBV models, or patients with CHB. We hope this review will contribute to an understanding of TCM and related active compounds as an effective treatment for CHB and provide useful information for the development of more effective antiviral drugs.

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Acupuncture with Long Dan Xie Gan Tang to Treat 36 Cases of Chronic Pelvic Inflammation

Cited by 4 publications

References 0 publications

Herb-Drug Interaction between the Traditional Hepatoprotective Formulation and Sorafenib on Hepatotoxicity, Histopathology and Pharmacokinetics in Rats

Herb-Drug Interaction between the Traditional Hepatoprotective Formulation and Sorafenib on Hepatotoxicity, Histopathology and Pharmacokinetics in Rats

Treating gynaecological disorders with traditional Chinese medicine: a review

Traditional Chinese medicine and related active compounds: A review of their role on hepatitis B virus infection

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