Acupuncture therapy improves health-related quality of life in patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis

Hsieh, Po‐Chun; Yang, Mei‐Chen; Wu, Yao‐Kuang; Chen, Hsin‐Yi; Tzeng, I‐Shiang; Hsu, Pei-Shan; Lee, Chang-Ti; Chen, Chien‐Lin; Cui, Lan

doi:10.1016/j.ctcp.2019.02.016

Cited by 31 publications

(41 citation statements)

References 21 publications

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“…Finally, we included 9 SRs. [15][16][17][18][19][20][21][22][23] The process of the literature search and screen is shown in Figure 1.…”

Section: Literature Search and Selectionmentioning

confidence: 99%

“…The characteristics of the 9 SRs included in our final analysis are summarized in Table 1. Five SRs 16,17,[21][22][23] were published in Chinese, and the other 4 15,[18][19][20] were published in English. The number of RCTs included in these SRs varied widely, ranging from 7 to 27, and the total number of participants ranged from 326 to 1298.…”

Section: Characteristics Of the Srsmentioning

confidence: 99%

“…[8][9][10] Proponents argue that acupuncture is effective at relieving symptoms and improving quality of life and activity endurance, and it is associated with fewer adverse effects than conventional approaches used to treat COPD. 11 In recent years, with the increasing number of clinical studies [12][13][14] on acupuncture treatment of COPD, a certain number of systematic reviews (SRs) [15][16][17][18][19][20][21][22][23] have been published to provide corresponding evidence supporting clinical decision-making. However, based on preliminary studies, the results of different systematic evaluations are not completely consistent, which are unable to effectively guide clinical practice.…”

Section: Introductionmentioning

confidence: 99%

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Role of Acupuncture in the Treatment of COPD: An Overview of Systematic Reviews

Liu¹,

Li²,

Feng³

et al. 2021

IJGM

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Background Since consistent evidence on the effectiveness of acupuncture in the treatment of chronic obstructive pulmonary disease (COPD) is not available, this overview aims to summarize and critically evaluate the methodological and evidence quality of systematic reviews (SRs) on this topic. Methods Eight electronic databases were searched to identify relevant SRs of the use of acupuncture in the treatment of COPD from inception to January 2021. Two researchers independently screened the literature, extracted the data, and cross-checked the data. The Assessing the Methodological Quality of Systematic Reviews 2 (AMSTAR 2) list was used to assess the methodological quality of SRs. The Grades of Recommendations, Assessment, Development and Evaluation (GRADE) system was used to assess the quality of evidence for the outcomes of interest. Results Nine SRs that conducted quantitative syntheses were included in this overview. The methodological quality of the SRs and the quality of evidence for the main outcome measures were generally unsatisfactory. Only 2 SRs were rated as low methodological quality by AMSTAR 2, and the remaining SRs were rated as critically low quality. The key limitations of the SRs were lack of a protocol and registration or a list of excluded studies. We did not find high-quality evidence to confirm the effectiveness of acupuncture for COPD, and the main reason was that the qualitative data synthesis relied on trials with small sample sizes and critically low quality. Conclusion Acupuncture appears to be an effective therapeutic method for COPD, but the credibility of the results is limited owing to the generally low methodological quality and evidence quality of the included SRs. Further rigorous and comprehensive studies are required to provide robust evidence and draw definitive conclusions.

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“…Finally, we included 9 SRs. [15][16][17][18][19][20][21][22][23] The process of the literature search and screen is shown in Figure 1.…”

Section: Literature Search and Selectionmentioning

confidence: 99%

Section: Characteristics Of the Srsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Role of Acupuncture in the Treatment of COPD: An Overview of Systematic Reviews

Liu¹,

Li²,

Feng³

et al. 2021

IJGM

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“…11 Other adjunctive nonpharmacological treatments may also improve HRQoL in patients with VTE and COPD. 12 The beneficial aspects of physical activity and other nonpharmacological treatments on quality of life could be investigated further in connection with VTE in combination with COPD. The aging population of patients with VTE and COPD increasingly has additional cardiovascular or malignant diseases.…”

Section: Vte Copd Physical Activity and Quality Of Lifementioning

confidence: 99%

Apixaban Interacts with Haemoglobin: Effects on Its Plasma Levels

et al. 2018

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The direct oral anticoagulant apixaban (APX), a strong factor Xa inhibitor, binds also to plasma proteins, especially albumin, and minimally to α1-acid glycoprotein. Although APX can cross the red cell membrane, due to its chemical structure, and could bind to haemoglobin (Hb), no investigation was performed on this possible phenomenon that could affect the APX plasma concentration and thus its pharmacokinetics and pharmacodynamics. We addressed this issue by (1) measuring the levels of APX and haematological/biochemical parameters in 90 patients on APX therapy; (2) assessing the effect of APX on oxygen saturation curves of Hb; (3) testing the direct APX binding to Hb by fluorescence spectroscopy and a zinc-induced precipitation of Hb coupled to a reversed-phase high-performance liquid chromatography (HPLC)-based method; and (4) simulating in silico by molecular docking the APX interaction with human Hb. In a multivariable analysis, Hb was the only independent variable significantly and inversely associated in 90 patients with APX peak plasma level, at variance with patients treated with rivaroxaban (n = 86) and dabigatran (n = 34) therapy. APX causes a progressive left-shift of the oxygen dissociation curve of purified Hb solution, with a Kd ≅300 µM. Fluorescence- and HPLC-based assays concordantly showed that APX binds to Hb with a Kd ≅350 µM. Finally, docking simulations showed that APX can fit into in the central cavity of Hb. These findings support the hypothesis that APX does bind to Hb, which, due to its millimolar concentration in blood, can act as ‘buffer’ for the drug and consequently affect its free plasma level.

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“…Recent systematic reviews have assessed acupuncture's efficacy for chronic obstructive pulmonary disease (COPD) [1][2][3] . These reviews have concluded that, even though acupuncture could have some benefits, the risk of bias of the included trials is too high to draw any strong conclusion.…”

Section: Introductionmentioning

confidence: 99%

Quality of reporting acupuncture interventions for chronic obstructive pulmonary disease: Review of adherence to the STRICTA statement

Fernández

Solà-Madurell

et al. 2020

F1000Res

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Background: The quality of reporting of acupuncture interventions is critical to ensure the applicability and reproducibility of acupuncture clinical trials. In the past, different publications have evaluated the quality of reporting of acupuncture interventions for different clinical situations, such as knee osteoarthritis, neurological diseases or cancer. However, this has not been done for acupuncture trials for chronic obstructive pulmonary disease (COPD). Objective: To assess the quality of reporting of acupuncture interventions in trials for COPD. Methods: A total of 11 English and Chinese databases were screened up until May 2019 for randomised or quasi-randomised control trials of acupuncture for COPD. The STRICTA checklist was used to determine the quality of the reporting of acupuncture interventions. Results: A total of 28 trials were included in our review. Out of the 16 STRICTA checklist subitems analysed, only 3 were considered appropriately reported in more than 70% of the trials, while 7 were correctly reported in less than 40%. Conclusion: The adherence to STRICTA guidelines of acupuncture trials for COPD is suboptimal, and future efforts need to be addressed to improve the quality of reporting.

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Acupuncture therapy improves health-related quality of life in patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis

Cited by 31 publications

References 21 publications

Role of Acupuncture in the Treatment of COPD: An Overview of Systematic Reviews

Role of Acupuncture in the Treatment of COPD: An Overview of Systematic Reviews

Apixaban Interacts with Haemoglobin: Effects on Its Plasma Levels

Quality of reporting acupuncture interventions for chronic obstructive pulmonary disease: Review of adherence to the STRICTA statement

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