Acupuncture Therapy for Psychiatric Illness

Pilkington, Karen

doi:10.1016/b978-0-12-411545-3.00010-9

Cited by 22 publications

(12 citation statements)

References 82 publications

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“…The electro‐acupuncture (EA) has been widely used to treat brain disorders 23,24 . According to the theory of traditional Chinese medicine, stimulations at the acupoints along Governor Vessel (GV) carry out beneficial effects against brain diseases.…”

Section: Introductionmentioning

confidence: 99%

Electro‐acupuncture alleviates adolescent cocaine exposure‐enhanced anxiety‐like behaviors in adult mice by attenuating the activities of PV interneurons in PrL

Nie

Wei

et al. 2020

FASEB j.

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We recently found that adolescent cocaine exposure (ACE) resulted in an enhancement of the γ‐aminobutyric acid (GABA) neurotransmitter system in the prelimbic cortex (PrL) of adult mice. Here, we aim to further investigate the role of GABAergic transmission, especially parvalbumin (PV) interneurons within PrL in the development of ACE‐induced anxiety‐like behavior, and to assess whether and how electro‐acupuncture (EA) therapeutically manage the ACE‐induced abnormal behaviors in adulthood. ACE mice exhibited the enhanced anxiety‐like behaviors in their adulthood, accompanied by increased GABAergic transmission and PV interneurons in PrL. Chemogenetic blocking PV interneurons in PrL alleviated ACE‐enhanced anxiety‐like behaviors in mice. Importantly, 37‐day EA treatments (mixture of 2 Hz/100 Hz, 1 mA, 30 minutes once a day) at the acupoints of Yintang (GV29) and Baihui (GV20) also alleviated ACE‐induced anxiety‐like behaviors, and rescued ACE‐impaired GABAergic neurotransmitter system and PV interneurons in PrL. In parallel, EA treatments further suppressed the activities of pyramidal neurons in PrL, suggesting that EA treatments seem to perform it beneficial effects on the ACE‐induced abnormal emotional behaviors by “calming down” the whole PrL. Collectively, these findings revealed that hyper‐function of GABAergic transmission, especially mediating by PV interneurons in PrL may be key etiology underlying ACE‐induced anxiety‐like behaviors. At least by normalizing the function of GABAergic and PV interneurons, EA may represent a promising therapeutic strategy for managing adolescent substance use‐related emotional disorders.

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Section: Introductionmentioning

confidence: 99%

Electro‐acupuncture alleviates adolescent cocaine exposure‐enhanced anxiety‐like behaviors in adult mice by attenuating the activities of PV interneurons in PrL

Nie

Wei

et al. 2020

FASEB j.

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“…Although it is an ancient therapeutic technique, acupuncture has been increasingly included in the management of neurological and psychiatric disorders, such as pain, insomnia, anxiety and depression (Pilkington, 2013;van der Watt et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Transcutaneous electrical acupoint stimulation as an adjunct therapy for obsessive-compulsive disorder: A randomized controlled study

Feng

Zhang

Zhu

et al. 2016

Journal of Psychiatric Research

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Background: Transcutaneous electrical acupoint stimulation (TEAS) is thought to have potential to treat obsessive-compulsive disorder (OCD).Objective: The purpose of this study was to determine whether adding TEAS to cognitive behavioral therapy (CBT) and clomipramine would improve the efficacy of these conventional treatments in OCD.Methods: In this randomized controlled trial, 360 OCD patients were assigned to receive TEAS combined with CBT plus clomipramine (Group A, n = 120), TEAS combined with CBT plus placebo (Group B, n = 120), and simulated (placebo) TEAS combined with CBT plus clomipramine (Group C, n = 120) for 12 weeks. The primary outcome was measured using the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS).Results: OCD symptoms in all patients reduced over time, however Groups A and B had a significantly greater reduction in Y-BOCS total score and the subscale for obsession and compulsion between week 2 and week 12 compared to Group C. Groups A and B had similar scores on these measures. Both groups had significantly higher rates of clinical response than Group C (88.3% and 81.7% vs. 67.5%, respectively, p < 0.001); and higher rates of remission (30.0% and 22.5% vs. 9.2%, respectively, p < 0.001).Group B experienced fewer adverse events than the other two groups.Conclusions: TEAS enhances the efficacy of conventional OCD interventions and avoids the adverse effects associated with conventional pharmacological treatment. It can be considered as an effective adjunct intervention for OCD.

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“…Present research suggests that the pathogenesis of PTSD is related to multiple neurobiologic systems, especially serotonergic (5-HT), noradrenalinergic, and neuropeptidergic systems, as well as the hypothalamic-pituitary-adrenal axis. [ 6 ] There is no doubt that PTSD can increase psychologic distress, and severely affect patients’ quality of life and social stability. Epidemiologic studies [ 7 – 9 ] have revealed that more than half of the world's population experience stressful events, about 25% and 30% of people who experience a traumatic event may develop PTSD, and the lifetime and average prevalence of PTSD are 6.8% and 8%, respectively.…”

Section: Introductionmentioning

confidence: 99%

Complementary and alternative therapies for post-traumatic stress disorder

et al. 2020

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Background: Post-traumatic stress disorder (PTSD) is a psychiatric disorder. While bringing psychologic pain to patients, it also damages their social function, which is a great threat to people's life and health. Complementary and alternative medicine (CAM) therapies have been used clinically to treat PTSD; however, the selection strategies of different CAM interventions in clinical practice is still uncertain, and the purpose of this study is to evaluate the efficacy and acceptability of different CAM therapies using systematic review and network meta-analysis. Methods: According to the strategy, the authors will retrieve a total of 7 electronic databases by June 2020. After a series of screening, the 2 researchers will use Aggregate Data Drug Information System and Stata software to analyze the data extracted from randomized controlled trials of CAM therapies for the PTSD. Finally, the evidence grade of the results will be evaluated. Results: This study will provide a reliable evidence for the selection of CAM therapies for PTSD. Conclusion: The results of this study will provide references for evaluating the influence of different CAM therapies for PTSD, and provide decision-making references for clinical research.

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Acupuncture Therapy for Psychiatric Illness

Cited by 22 publications

References 82 publications

Electro‐acupuncture alleviates adolescent cocaine exposure‐enhanced anxiety‐like behaviors in adult mice by attenuating the activities of PV interneurons in PrL

Electro‐acupuncture alleviates adolescent cocaine exposure‐enhanced anxiety‐like behaviors in adult mice by attenuating the activities of PV interneurons in PrL

Transcutaneous electrical acupoint stimulation as an adjunct therapy for obsessive-compulsive disorder: A randomized controlled study

Complementary and alternative therapies for post-traumatic stress disorder

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