Acupuncture stimulation at GB34 suppresses 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced oxidative stress in the striatum of mice

Lee, Yukyung; Choi, Gaeun; Jeon, Hyongjun; Kim, Dong-Soo; Ryu, Sun Young; Koo, Sungtae; Ha, Ki‐Tae; Kim, Seungtae

doi:10.1007/s12576-017-0547-7

Cited by 14 publications

(13 citation statements)

References 26 publications

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“…In 6-hydroxydopamine (6-OHDA) rats, acupuncture at Yanglingquan (GB34), Taichong (LV3), Zusanli (ST36), and Xuehai (SP10) acupoints increased SOD and GSH-Px levels, reduced MDA level, and inhibited oxidative stress [ 79 ]. Moreover, in the striatum of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- (MPTP-) treated mice, acupuncture at Yanglingquan (GB34) could enhance SOD and CAT activities [ 80 ]. High-frequency (100-Hz) EA at Zusanli (ST36) and Sanyinjiao (SP6) acupoints can reduce H 2 O 2 and MDA levels and increase SOD, GSH, and GSH-Px levels [ 81 ].…”

Section: Resultsmentioning

confidence: 99%

Effects of Acupuncture on Oxidative Stress Amelioration via Nrf2/ARE-Related Pathways in Alzheimer and Parkinson Diseases

Huang

Hsieh

2021

Evidence-Based Complementary and Alternative Medicine

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Oxidative stress is responsible for the pathogeneses of various diseases. Mitochondrial dysfunction, impaired DNA repair, and cellular damage followed by oxidative stress contribute to neurodegenerative diseases, such as Alzheimer disease (AD) and Parkinson disease (PD). Acupuncture is a traditional therapy that has been practiced for >3000 years in Asia. Many studies have demonstrated that acupuncture has notable antioxidative, anti-inflammatory, and antiapoptotic effects. However, the exact mechanism remains unclear. Nuclear factor erythroid 2-related factor (Nrf2) is crucial in regulating the redox equilibrium. Activated Nfr2 translocates into the nucleus, binds to the antioxidant response element (ARE), and initiates antioxidative enzyme transcription. In this review, we demonstrated the effects of acupuncture on oxidative stress amelioration in AD and PD animal models through Nrf2/ARE pathway activation and Nrf2/ARE-related pathway regulation. Thus, acupuncture could be a therapeutic option for AD and PD.

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Section: Resultsmentioning

confidence: 99%

Effects of Acupuncture on Oxidative Stress Amelioration via Nrf2/ARE-Related Pathways in Alzheimer and Parkinson Diseases

Huang

Hsieh

2021

Evidence-Based Complementary and Alternative Medicine

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“…For the CCI model EA treatment group, the mouse received EA on the left “Huantiao” (GB30) and “Yanglingquan” (GB34) once a day, starting from the eighth day after operation. GB30 and GB34 were chosen based on their effect in improving inflammatory pain and neuropathic pain in mouse (Kang et al, 2007; Park et al, 2014; Lee et al, 2018). Two acupuncture needles were inserted 2–3 mm deep into two acupoints corresponding to GB30 and GB34 in humans.…”

Section: Methodsmentioning

confidence: 99%

Inhibition of GABAergic Neurons and Excitation of Glutamatergic Neurons in the Ventrolateral Periaqueductal Gray Participate in Electroacupuncture Analgesia Mediated by Cannabinoid Receptor

Zhang

Xiang

et al. 2019

Front. Neurosci.

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Although electroacupuncture (EA) has become a worldwide practice, little is understood about its precise target in the central nervous system (CNS) and the cell type-specific analgesia mechanism. In the present study, we found that EA has significant antinociceptive effects both in inflammatory and neuropathic pain models. Chemogenetic inhibition of GABAergic neurons in the ventrolateral periaqueductal gray (vlPAG) replicated the effects of EA, whereas the combination of chemogenetic activation of GABAergic neurons and chemogenetic inhibition of glutamatergic neurons in the vlPAG was needed to reverse the effects of EA. Specifically knocking out CB1 receptors on GABAergic neurons in the vlPAG abolished the EA effect on pain hypersensitivity, while specifically knocking out CB1 receptors on glutamatergic neurons attenuated only a small portion of the EA effect. EA synchronously inhibits GABAergic neurons and activates glutamatergic neurons in the vlPAG through CB1 receptors to produce EA-induced analgesia. The CB1 receptors on GABAergic neurons localized in the vlPAG was the basis of the EA effect on pain hypersensitivity. This study provides new experimental evidence that EA can bidirectionally regulate GABAergic neurons and glutamatergic neurons via the CB1 receptors of the vlPAG to produce analgesia effects.

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“…It also enhances the availability of synaptic dopamine [16], decreases the effective dose of levodopa, and relieves side effects [17]. Thus, GB34 is an appropriate acupoint to treat PD [18–21].…”

Section: Introductionmentioning

confidence: 99%

Effects of Combined Treatment with Acupuncture and Chunggan Formula in a Mouse Model of Parkinson’s Disease

Hwang

Song

Ahn

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Parkinson's disease is the second most common neurodegenerative disease. Patients with Parkinson's disease can be treated with a combination of acupuncture and herbal medicine, but studies on the synergistic effects of the combined treatment have not yet been conducted. Thus, we subjected an MPTP-induced Parkinson's disease mouse model to the combined treatment. We used acupoint GB34 for acupuncture and modified Chunggantang (KD5040) as the herbal medicine, as they have been reported to be effective in Parkinson's disease. We investigated the suboptimal dose of KD5040 and then used this dose in the combined treatment. The results showed that the combined treatment had a synergistic effect on improvements in abnormal motor function and neurodegeneration compared with the use of acupuncture or herbal medicine alone. The combined treatment also had a neuroprotective effect via the PI3K/AKT and MAPK/ERK signaling pathways. These findings suggest that the combined treatment with acupuncture and KD5040 can help improve the symptoms of Parkinson's disease.

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Acupuncture stimulation at GB34 suppresses 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced oxidative stress in the striatum of mice

Cited by 14 publications

References 26 publications

Effects of Acupuncture on Oxidative Stress Amelioration via Nrf2/ARE-Related Pathways in Alzheimer and Parkinson Diseases

Effects of Acupuncture on Oxidative Stress Amelioration via Nrf2/ARE-Related Pathways in Alzheimer and Parkinson Diseases

Inhibition of GABAergic Neurons and Excitation of Glutamatergic Neurons in the Ventrolateral Periaqueductal Gray Participate in Electroacupuncture Analgesia Mediated by Cannabinoid Receptor

Effects of Combined Treatment with Acupuncture and Chunggan Formula in a Mouse Model of Parkinson’s Disease

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