Acupuncture reversed hippocampal mitochondrial dysfunction in vascular dementia rats

Li, Hui; Liu, Yi; Lin, Li-Ting; Wang, Xuerui; Du, Shoucheng; Yan, Chao-Qun; He, Tianbiao; Yang, Jing‐Wen; Liu, Cun‐Zhi

doi:10.1016/j.neuint.2015.12.001

Cited by 40 publications

(69 citation statements)

References 36 publications

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“…The hippocampus, as the core for spatial learning and memory, is highly susceptible to hypoperfusion‐induced lesions. Our previous study proved that acupuncture could activate the antioxidant effects or reverse hippocampal mitochondrial dysfunction to prevent spatial memory deficits . The major cellular processes observed in our proteomic changes were associated with oxidative stress, apoptosis, and synaptic functions, revealing that acupuncture possibly regulates the brain tissue repair via regulating oxidative stress, apoptosis, or synaptic functions.…”

Section: Discussionmentioning

confidence: 54%

Acupuncture as a multifunctional neuroprotective therapy ameliorates cognitive impairment in a rat model of vascular dementia: A quantitative iTRAQ proteomics study

et al. 2018

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Aims: Acupuncture has been reported to affect vascular dementia through a variety of molecular mechanisms. An isobaric tag for relative and absolute quantification (iTRAQ) with high-resolution liquid chromatography-tandem mass spectrometry (LC-MS/MS) analyses makes it possible to attain a global profile of proteins. Hence, we used an iTRAQ-LC-MS/MS strategy to unravel the underlying mechanism of acupuncture.Methods: Wistar rats were subjected to vascular dementia with bilateral common carotid occlusion. Acupuncture was intervened for 2 weeks at 3 days after surgery.The Morris water maze was used to assess the cognitive function. Proteins were screened by quantitative proteomics and analyzed by bioinformatic analysis. Four differentially expressed proteins (DEPs) were validated by western blot. The reactive oxygen species (ROS) production, neuron cell loss, and long-term potentiation (LTP) were determined after western blot.Results: Acupuncture at proper acupoints significantly improved cognitive function.A total of 31 proteins were considered DEPs. Gene ontology (GO) analysis showed that most of the DEPs were related to oxidative stress, apoptosis, and synaptic function, which were regarded as the major cellular processes related to acupuncture effect. Western blot results confirm the credibility of iTRAQ results. Acupuncture could decrease ROS production, increase neural cell survival, and improve LTP, which verified the three major cellular processes. Conclusion: Acupuncture may serve as a promising clinical candidate for the treatment of vascular dementia via regulating oxidative stress, apoptosis, or synaptic functions. K E Y W O R D S acupuncture, iTRAQ, proteomics, vascular dementia 1 | INTRODUC TI ON Vascular dementia (VaD) as the second most common cognitive disorders, following Alzheimer's disease (AD), is caused by a series of cardiac-cerebral vascular conditions that are characterized by loss of cognitive functions. 1,2 The worldwide number of patients with VaD is estimated to rise because no effective prevention or treatment strategy is available. 3 Progress toward finding effective treatments for VaD S U PP O RTI N G I N FO R M ATI O N Additional supporting information may be found online in the Supporting Information section at the end of the article. How to cite this article: Yang J-W, Wang X-R, Zhang M, et al. Acupuncture as a multifunctional neuroprotective therapy ameliorates cognitive impairment in a rat model of vascular dementia: A quantitative iTRAQ proteomics study. CNS

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Section: Discussionmentioning

confidence: 54%

Acupuncture as a multifunctional neuroprotective therapy ameliorates cognitive impairment in a rat model of vascular dementia: A quantitative iTRAQ proteomics study

et al. 2018

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“…On the third day after operation, acupuncture treatment was performed by the acupuncturist at specific acupoints bilateral “Zusanli” (ST36, 5 mm distal to the head of the fibula beneath the stifle and 2 mm lateral to the tibial tuberosity) and “Baihui” (DU20, on the midline of the head and the line connecting the apices of both auricles), with needles (0.3 mm×40 mm, Hwato, China). Detailed method and procedure of acupuncture treatment were as previously described . Other groups were given the same catching‐grasping stimulus as the acupuncture group.…”

Section: Methodsmentioning

confidence: 99%

“…Detailed method and procedure of acupuncture treatment were as previously described. 22 Other groups were given the same catchinggrasping stimulus as the acupuncture group.…”

Section: Surgery Sirna Injection and Acupuncture Treatmentmentioning

confidence: 99%

Acupuncture inhibits TXNIP‐associated oxidative stress and inflammation to attenuate cognitive impairment in vascular dementia rats

et al. 2017

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“…Reduced eNOS activity can decrease endothelial NO levels resulting in reduced cerebral blood flow (Najjar et al, 2013;Toda and Okamura, 2012). The development of cerebral hypoperfusion may also be linked to impaired vasodilation that is mechanistically linked to reduced neurovascular eNOS-dependent NO biosynthesis (Li et al, 2016a;Liu et al, 2016;Najjar et al, 2013). Moreover, sustained cerebral hypoperfusion can further compromise endothelial mitochondrial oxidative function, increasing the formation of endothelial ROS (Aliev et al, 2010(Aliev et al, , 2014Liu and Zhang, 2012), which in turn promotes eNOS uncoupling and lowers endothelial NO levels, thereby further reducing cerebral perfusion in a positive feedback loop (Antoniades, 2006;Chen et al, 2010;Lavoie et al, 2010).…”

Section: Chronically Elevated Oxidative and Nitrosative Stress And Damentioning

confidence: 99%

Leaky brain in neurological and psychiatric disorders: Drivers and consequences

Morris

Fernandes

Puri

et al. 2018

Aust N Z J Psychiatry

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Chronic inflammatory and oxidative and nitrosative stress is associated with the development of a 'leaky gut'. The following evidence-based approaches, which address the leaky gut and blood-brain barrier dysfunction, are suggested as potential therapeutic interventions for neurological and neuropsychiatric disorders: melatonin, statins, probiotics containing Bifidobacteria and Lactobacilli, N-acetylcysteine, and prebiotics containing fructo-oligosaccharides and galacto-oligosaccharides.

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Acupuncture reversed hippocampal mitochondrial dysfunction in vascular dementia rats

Cited by 40 publications

References 36 publications

Acupuncture as a multifunctional neuroprotective therapy ameliorates cognitive impairment in a rat model of vascular dementia: A quantitative iTRAQ proteomics study

Acupuncture as a multifunctional neuroprotective therapy ameliorates cognitive impairment in a rat model of vascular dementia: A quantitative iTRAQ proteomics study

Acupuncture inhibits TXNIP‐associated oxidative stress and inflammation to attenuate cognitive impairment in vascular dementia rats

Leaky brain in neurological and psychiatric disorders: Drivers and consequences

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