Acupuncture regulates the glucose metabolism in cerebral functional regions in chronic stage ischemic stroke patients—a PET-CT cerebral functional imaging study

Abstract

BackgroundAcupuncture has been applied to aid in the recovery of post-stroke patients, but its mechanism is unclear. This study aims to analyze the relationship between acupuncture and glucose metabolism in cerebral functional regions in post-stroke patients using 18 FDG PET-CT techniques. Forty-three ischemic stroke patients were randomly divided into 5 groups: the Waiguan (TE5) needling group, the TE5 sham needling group, the sham point needling group, the sham point sham needling group and the non-needling group. Cerebral functional images of all patients were then acquired using PET-CT scans and processed by SPM2 software.ResultsCompared with the non-needling group, sham needling at TE5 and needling/sham needling at the sham point did not activate cerebral areas. However, needling at TE5 resulted in the activation of Brodmann Area (BA) 30. Needling/sham needling at TE5 and needling at the sham point did not deactivate any cerebral areas, whereas sham needling at the sham point led to deactivation in BA6. Compared with sham needling at TE5, needling at TE5 activated BA13, 19 and 47 and did not deactivate any areas. Compared with needling at the sham point, needling at TE5 had no associated activation but a deactivating effect on BA9.ConclusionNeedling at TE5 had a regulating effect on cerebral functional areas shown by PET-CT, and this may relate to its impact on the recovery of post-stroke patients.

White matter injury in ischemic stroke

“…A number of clinical studies and evidence-based literature analyses have demonstrated that acupuncture has a positive effect on post-stroke rehabilitation (Huang et al, 2012). However, the underlying mechanisms are still unclear.…”

The Status of the Quality Control in Acupuncture‐Neuroimaging Studies

“…Most of the studies were conducted in China (80 studies) [10, 11, 13, 14, 16, 18–24, 26, 27, 29–31, 33–36, 43–46, 48, 51, 53, 54, 56, 58–66, 68–70, 72–75, 77, 78, 83, 84, 86, 87, 89, 90, 93, 95, 97, 99–101, 104, 111, 113, 115, 123, 137, 138, 142, 144–147, 154, 159, 161–166] and in USA (40 studies) [15, 28, 37, 38, 42, 57, 70, 71, 76, 80, 88, 91, 94, 96, 105–107, 118–120, 124–127, 129–131, 133–136, 140, 141, 148, 151, 152, 155, 156, 158, 174]. The investigators in Korea (16 studies) [7, 47, 49, 52, 55, 82, 85, 98, 102, …”

“…25 studies were [10, 26–29, 34, 38, 49, 51, 58–60, 62, 65, 71, 84, 101, 105, 108, 112, 134, 137, 139, 142, 145] performed on patients. 21 studies [14, 18–23, 37, 40, 46–48, 52, 61, 77, 131, 133, 138, 141, 146, 165] recruited both healthy subjects and patients.…”

“…25 kinds of diseases were involved in these studies (Table 1). 19 studies [10, 14, 18, 19, 29, 34, 35, 40, 46, 51, 52, 59, 62, 65, 77, 84, 112, 134, 146] classified the subtypes of diseases.…”

“…100 studies [7, 10, 16–19, 23, 24, 26, 27, 30, 34, 35, 39–42, 44–48, 51–54, 57, 59, 60, 62, 63, 65, 69–74, 76, 77, 80–82, 84, 85, 87, 89, 92, 97, 98, 101–103, 105, 107–109, 112, 114, 116, 117, 120–122, 124, 125, 129, 131–135, 137, 139, 141–145, 148–153, 157, 158, 160, 162, 164, 166–168, 171–176] described the age range of participants. For the healthy subjects, the average age range was 18.3 years old, and the maximal age range was 62, while the minimal age range was 3.…”