Acupuncture modulates spontaneous activities in the anticorrelated resting brain networks

Bai, Lijun; Qin, Wei; Tian, Jie; Dong, Minghao; Pan, Xiaohong; Chen, Peng; Dai, Jianping; Yang, Weiping; Liu, Yijun

doi:10.1016/j.brainres.2009.04.056

Cited by 101 publications

(101 citation statements)

References 60 publications

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“…It was consistent with electrophysiological studies and clinical investigations (35) showing the insula's involvement in emotional processing (fear, uneasiness, and so forth) and ascending visceral symptoms (36). This also coincided with another observation, which suggested that acupuncture modulated the centralexecutive network (CEN) and default mode network (DMN) networks anchored by the anterior insula (1). The involvement of the insula during acupuncture stimulation is also consistent with TCM's viewpoint that the acupuncture may mediate physical disorders through the insular visceral feedback pathway (1,2,27).…”

Section: Discussionsupporting

confidence: 88%

“…Activation in the brainstem in the homogeneous group was evident. Several acupuncture studies have already emphasized the importance brainstem in the endogenous monoaminergic and opioidergic systems (1,4). The activation of SII and the thalamus was expected under somatosensory stimulation at somatic points (37), and the thalamus is also part of the reported neuromatrix of pain (38,39).…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of group homogeneity during acupuncture stimulation in fMRI studies

Sun

Qin

Dong

et al. 2010

Magnetic Resonance Imaging

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Purpose: To evaluate the extent of individual differences of functional MRI (fMRI) signal changes induced by acupuncture stimulation. Materials and Methods:Acupuncture at ST36 and checkerboard stimulation was applied to 16 subjects. We calculated the mean distance using beta values in a generalized linear model (GLM) analysis and employed it to study the group homogeneity by detecting the outliers.Results: A more significant individual difference was presented in acupuncture stimulation compared with visual stimulation through evaluation of the mean distance. From the group results, we found that the activations were more significant in the homogeneous group results. Combining the behavior and fMRI results, there was no direct correlation between deqi index and mean distance in acupuncture stimulation. The deqi index of the outlier was in the normal range and did not differ significantly from others. Conclusion:Traditional group results without removing outliers were not sensitive enough to detect the real acupuncture effect. We suggest that individual difference should be taken into consideration for future acupuncture studies. Also, group analysis paralleled with individual analysis is critical for a full understanding of acupuncture effects.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Evaluation of group homogeneity during acupuncture stimulation in fMRI studies

Sun

Qin

Dong

et al. 2010

Magnetic Resonance Imaging

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“…This indicated that acupuncture may operate through the regulation of autonomic nervous system, which was consistent with increasing evidence for the involvement of autonomic efferent nerve activity underlying its analgesia effects [36][37][38]. Though preliminary, this phenomenon may reflect the specific neuro-modulatory effect of acupuncture on the resting brain [39,40]. In addition, a recent study has reported differences in resting-state brain functions of people with chronic pain in contrast with controls, and the authors proposed that this difference in resting-state brain activity might reflect the cognitive and affective complications of chronic pain [41].…”

Section: Sustained Effects Of Acupuncture and Its Influence On Fmri Rsupporting

confidence: 83%

Spatiotemporal Modulation of Central Neural Pathway Underlying Acupuncture Action: A Systematic Review

Bai¹,

Qin²,

Liang³

et al. 2009

CMIR

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Acupuncture, an ancient therapeutic technique, is currently gaining popularity as an important modality of alternative and complementary medicine in the West world. Concurrently, scientific interests in exploring whether acupuncture is therapeutically effective are raised alongside those about the means by which it may operate. Modern neuroimaging techniques such as functional magnetic resonance imaging, positron emission tomography, electroencephalography, and magnetoencephalography provide a means to safely monitor brain activity in humans. In this review, we have summarized evidence derived from the neuroimaging studies and tried to elucidate the neurophysiological correlates of acupuncture. Previous investigations on the neural responses to acupuncture mainly focus on its acute effects and explore the correlation between the specific acupoints and cortical activations only in the spatial domain. However, abundant clinical reports and psychophysical analysis suggest the kinetics of acupuncture is longer acting as a function of time. Consequentially, an accurate interpretation of acupuncture actions depends on how effectively we can characterize the nature of temporal variations underlying neural activities, rather than simply detect the occurrence of such changes. This emerging picture indicates that both designing paradigms and statistical models involved in acupuncture studies should be applied with great care.

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“…Interestingly, acupuncture seems to influence the extent of this deactivation. Bai et al [52] and Hui et al [53] report that genuine acupuncture leads to stronger DMN deactivation than sham acupuncture or tactile stimulation [54]. This finding calls for research on the clinical impact of acupuncture on diseases that are associated with attenuated DMN deactivation in response to an external task such as depression [33,34,55].…”

Section: Peripheral Effects Of Acupuncture Analgesiamentioning

confidence: 99%

Acupuncture-Induced Pain Relief and the Human Brains Default Mode Network an Extended View of Central Effects of Acupuncture Analgesia

Otti

Noll‐Hussong

2012

Forsch Komplementmed

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As a complementary medical procedure, acupuncture has a significant impact on the treatment of acute and chronic pain. Though the physiological mechanisms behind this method are still unclear, acupuncture has been claimed to rely also on changes in the central nervous system. Recent functional imaging studies indicate that the so-called default mode network (DMN) which consists of cortical midline structures and lateral parietal regions plays an important role in these processes. This brief overview describes the effects of analgesic acupuncture on the DMN architecture. The stronger interplay between systems dedicated to endogenous analgesia (periaqueductal gray), affective processing (anterior cingulate cortex, amygdala), memory (hippocampus), and self-projective thinking (DMN) following this therapy supports the notion that acupuncture is a mind-body therapy which helps to reintegrate important neural dimensions of inner life and to establish psychophysical pain homeostasis.

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Acupuncture modulates spontaneous activities in the anticorrelated resting brain networks

Cited by 101 publications

References 60 publications

Evaluation of group homogeneity during acupuncture stimulation in fMRI studies

Evaluation of group homogeneity during acupuncture stimulation in fMRI studies

Spatiotemporal Modulation of Central Neural Pathway Underlying Acupuncture Action: A Systematic Review

Acupuncture-Induced Pain Relief and the Human Brains Default Mode Network an Extended View of Central Effects of Acupuncture Analgesia

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Acupuncture modulates spontaneous activities in the anticorrelated resting brain networks

Cited by 101 publications

References 60 publications

Evaluation of group homogeneity during acupuncture stimulation in fMRI studies

Evaluation of group homogeneity during acupuncture stimulation in fMRI studies

Spatiotemporal Modulation of Central Neural Pathway Underlying Acupuncture Action: A Systematic Review

Acupuncture-Induced Pain Relief and the Human Brains Default Mode Network  an Extended View of Central Effects of Acupuncture Analgesia

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Product

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Acupuncture-Induced Pain Relief and the Human Brains Default Mode Network an Extended View of Central Effects of Acupuncture Analgesia