Acupuncture-mediated inhibition of inflammation facilitates significant functional recovery after spinal cord injury

Choi, Doo C.; Lee, Jee Y.; Moon, Youn Joo; Kim, Shin‐Woo; Oh, Tae Hwan; Yune, Tae Young

doi:10.1016/j.nbd.2010.04.003

Cited by 108 publications

(94 citation statements)

References 58 publications

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“…One week after surgery, the rats were sacrificed for apoptosis analysis (Choi et al, 2010). Briefly, formalinfixed and OCT-embedded spinal cords were processed to sections.…”

Section: Methodsmentioning

confidence: 99%

Valproic acid improves locomotion in vivo after SCI and axonal growth of neurons in vitro

Han

Sun

et al. 2012

Experimental Neurology

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Previous studies have found that valproic acid (VPA), a histone deacetylases (HDAC) inhibitor, improves outcomes in a rat model of spinal cord injury (SCI). The study here aimed to further illuminate the neuroprotective effects of VPA against SCI, both in vivo and in vitro. First, spinal cord injury was performed in rats using NYU impactor. Delayed VPA injection (8 h following SCI) significantly accelerated locomotor recovery. VPA therapy also suppressed SCI-induced hypoacetylation of histone and promoted expressions of BDNF and GDNF. Next, the influence of VPA on axonal growth inhibited by a myelin protein was tested. Neurons from embryonic spinal cord or hippocampus were cultured on plates coated with Nogo-A peptide, and escalating concentrations of VPA were added into the cultures. VPA treatment, in a concentration dependent manner, allowed neurons to overcome Nogo-A inhibition of neurite outgrowth. Meanwhile, VPA exposure increased the level of histone acetylation and expression of BDNF in spinal neurons. Cumulatively, these findings indicate that VPA is possibly a promising medication and deserves translational trials for spinal cord injury.

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“…One week after surgery, the rats were sacrificed for apoptosis analysis (Choi et al, 2010). Briefly, formalinfixed and OCT-embedded spinal cords were processed to sections.…”

Section: Methodsmentioning

confidence: 99%

Valproic acid improves locomotion in vivo after SCI and axonal growth of neurons in vitro

Han

Sun

et al. 2012

Experimental Neurology

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show abstract

“…Percentage of field analysis was used to provide a quantitative estimate (proportional) of changes in the activation state of microglia as previously described (Popovich et al, 1997;Hains and Waxman, 2006;Choi et al, 2010). After immunofluorescence staining with CD11b antibody (Millipore), images were taken with Lympus BX-52 microscope connected via CoolSNAP digital camera (Roper Scientific, Tucson, AZ).…”

Section: Quantitation Of the Proportion Of Resting And Activated Micrmentioning

confidence: 99%

MMP-3 secreted from endothelial cells of blood vessels after spinal cord injury activates microglia, leading to oligodendrocyte cell death

Lee

Choi

Yune

2015

Neurobiology of Disease

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“…The expressions of a variety of inflammatory cytokines are increased after ASCI, which then mediate immune and inflammatory responses through the cytokine network to enhance cascading inflammatory responses. Doo C. Choi found acupuncture significantly reduced the expression of proinflammatory factors [2]. This study also showed that the damaged zone and its adjacent tissue contained a large number of activated neutrophils, lymphocytes and glial cells, which secreted a large amount of inflammatory factors, which then interacted to worsen the SCI [3,4].…”

Section: Introductionmentioning

confidence: 61%

The Elongated Needle Therapy-Mediated Inhibition of Inflammation Facilitates Functional Recovery after Acute Spinal Cord Injury

Quan¹

2016

ACIM

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Acupuncture-mediated inhibition of inflammation facilitates significant functional recovery after spinal cord injury

Cited by 108 publications

References 58 publications

Valproic acid improves locomotion in vivo after SCI and axonal growth of neurons in vitro

Valproic acid improves locomotion in vivo after SCI and axonal growth of neurons in vitro

MMP-3 secreted from endothelial cells of blood vessels after spinal cord injury activates microglia, leading to oligodendrocyte cell death

The Elongated Needle Therapy-Mediated Inhibition of Inflammation Facilitates Functional Recovery after Acute Spinal Cord Injury

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