Acupuncture-mediated inhibition of ethanol-induced dopamine release in the rat nucleus accumbens through the GABAB receptor

Yoon, Seong Shoon; Kwon, Young Kyu; Kim, Mi Ryeo; Shim, Insop; Kim, Kwang Joong; Lee, Mann Hyung; Lee, Young Sun; Golden, Gregory T.; Yang, Chae Ha

doi:10.1016/j.neulet.2004.07.095

Cited by 69 publications

(55 citation statements)

References 18 publications

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“…Only mice whose probes were located within the NAC were included in the statistical analysis of the data Hamon 1995; Heinz et al 2003;Koob 2003;De Witte 2004;Johnson 2005). Both serotonin and GABA can inhibit glutamate transmission within various limbic structures, including the NAC (e.g., Dijk et al 1995;Cheng et al 1998;Golembiowska and Dziubina 2002;Fadda et al 2003;Xi et al 2003;Szumlinski et al 2004b;Yoon et al 2004). Thus, a tolerance to the GABA and serotonin enhancing effects of alcohol with repeated high alcohol intake bouts may contribute to the sensitization of glutamatergic neurotransmission within the NAC postulated as critical for the expression of addictive behavior (Everitt and Wolf 2002;Kalivas et al 2005;Chandler et al 2006).…”

Section: Resultsmentioning

confidence: 99%

Accumbens neurochemical adaptations produced by binge-like alcohol consumption

et al. 2007

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Section: Resultsmentioning

confidence: 99%

Accumbens neurochemical adaptations produced by binge-like alcohol consumption

et al. 2007

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“…Animal studies suggest that auricular acupuncture activates g-aminobutyric acid receptors, which reduces symptoms of morphine withdrawal, 16 and there is support for the hypothesis that opioid release stimulated by acupuncture helps to restore the release of dopamine. 17 In particular, auricular acupuncture potentially modifies autonomic dysfunction by increasing parasympathetic activity 18 and reduces sympathetic hyperactivity, 19 and stimulation of the liver 3 acupuncture point (LR 3; Tai Chong) activates several cortical and subcortical regions responsible for acute and chronic pain. 20 Recently, acupuncture treatment has been described as effective and safe in children 21 and newborns.…”

Section: What This Study Addsmentioning

confidence: 99%

Laser Acupuncture for Neonatal Abstinence Syndrome: A Randomized Controlled Trial

et al. 2015

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BACKGROUND: Neonatal abstinence syndrome (NAS) is usually treated with opiate derivatives and supported with nonpharmacological treatment.METHODS: This prospective, randomized, controlled, blinded, single-center study was carried out between March 2009 and November 2014. Newborn infants diagnosed with NAS after maternal opioid substitution therapy were eligible for inclusion. Infants were randomly allocated to the acupuncture group (combining laser acupuncture and pharmacological therapy of morphine and phenobarbital) or control group (pharmacological therapy alone). Laser acupuncture was performed with a LABpen MED 10 (675 nm/10 mW) at 5 ear and 4 body acupuncture points, bilaterally, and sessions were repeated every day. The primary outcome measure was duration of oral morphine therapy for NAS. Secondary outcomes included highest single Finnegan score, time to highest single Finnegan score, maximum amount of oral morphine solution (in milliliters per kilogram and milligrams per kilogram), time to maximum amount of oral morphine solution, and length of hospital stay.RESULTS: Twenty-eight newborns (14 in each group) were eligible for analysis. Duration of oral morphine therapy was significantly reduced in the acupuncture group compared with the control group (28 vs 39 days, respectively, P = .019). In addition, we observed a significantly reduced length of hospital stay in the acupuncture group compared with the control group (35 days [interquartile range 25 to 47] vs 50 days [36 to 66], P = .048).CONCLUSIONS: Adjunctive laser acupuncture significantly reduced the duration of morphine therapy in newborns with NAS. WHAT'S KNOWN ON THIS SUBJECT:The impact of neonatal abstinence syndrome is of concern because the number of newborns showing symptoms of withdrawal after intrauterine drug exposure is increasing worldwide. Newborns developing neonatal abstinence syndrome require prolonged medical treatment and longer hospital admission after birth. WHAT THIS STUDY ADDS:This first randomized controlled trial presents data on newborns with neonatal abstinence syndrome treated with laser acupuncture. The findings suggest that adjuvant laser acupuncture has the potential to reduce duration of morphine therapy and length of hospital stay. Dr Raith conceptualized and designed the study, provided oversight for the research procedures and data acquisition, contributed to the interpretation of the data, wrote the first draft of the article, and revised the final manuscript; Dr Schmölzer made substantial contributions to the conceptualization of the study and performed data acquisition and interpretation of data; Drs Schmölzer, Resch, Reiterer, and Avian made substantial contributions to the design of the study; Drs Raith, Resch, Reiterer, Avian, Köstenberger, and Urlesberger reviewed the manuscript and made revisions; Drs Resch and Reiterer made substantial contributions to the randomization procedures and maintained and ensured the masking of personnel; Dr Avian performed statistical analysis and interpretation of dat...

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“…As evidenced, EA has been reported to counteract the effects of a variety of drugs of abuse, including morphine [6] and alcohol [7][8][9][10][11]. Because EA can suppress alcohol withdrawal symptoms [7] and inhibits alcohol-stimulated release of dopamine in nucleus accumbens [8], it was predicted that the application of EA would reduce alcohol intake in alcohol-preferring rats.…”

Section: Introductionmentioning

confidence: 99%

“…Because EA can suppress alcohol withdrawal symptoms [7] and inhibits alcohol-stimulated release of dopamine in nucleus accumbens [8], it was predicted that the application of EA would reduce alcohol intake in alcohol-preferring rats. Furthermore, because there is evidence that opiate mechanisms may be involved in the actions of EA [12][13][14], it was predicted that pretreatment with the opiate antagonist naltrexone prior to EA application would counteract the effects of EA.…”

Section: Introductionmentioning

confidence: 99%

Electroacupuncture Reduces Voluntary Alcohol Intake in Alcohol-preferring Rats via an Opiate-sensitive Mechanism

Overstreet¹,

Cui

et al. 2008

Neurochem Res

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Electroacupuncture (EA) has been shown to modify the effects of various drugs of abuse, including alcohol. Inbred P rats were trained to drink alcohol voluntarily and then subjected to two periods of alcohol deprivation lasting 3 days. During the second deprivation, the rats received either EA or sham EA. The rats were pretreated with naltrexone (5 mg/kg) or saline 30 min before each of the EA or sham EA sessions. Approximately 6 h after the last naltrexone or saline treatment, the alcohol tubes were returned and alcohol and water intakes were recorded later at 2, 4, 6, and 24 h. Only EA led to a decrease in alcohol intake, which was most prominent at 6 and 24 h, and this inhibitory effect of EA was blocked by naltrexone, suggesting that activation of the endogenous opiate system may be responsible for EA's effects on alcohol intake in the alcohol-dependent iP rats.

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Acupuncture-mediated inhibition of ethanol-induced dopamine release in the rat nucleus accumbens through the GABAB receptor

Cited by 69 publications

References 18 publications

Accumbens neurochemical adaptations produced by binge-like alcohol consumption

Accumbens neurochemical adaptations produced by binge-like alcohol consumption

Laser Acupuncture for Neonatal Abstinence Syndrome: A Randomized Controlled Trial

Electroacupuncture Reduces Voluntary Alcohol Intake in Alcohol-preferring Rats via an Opiate-sensitive Mechanism

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