Acupuncture is effective to attenuate stress and stimulate lymphocyte proliferation in the elderly

Pavão, Tiago Sebastiá; Vianna, Priscila; Pillat, Micheli Mainardi; Machado, A. B.; Bauer, Moisés Evandro

doi:10.1016/j.neulet.2010.08.016

Cited by 37 publications

(27 citation statements)

References 19 publications

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“…A clinically important improvement (2 points on the esas) clear. Several studies of varying methodologic rigour suggest that acupuncture can potentially help manage cancer symptoms such as pain, lack of appetite, nausea, emotional distress, depression, and anxiety [13][14][15][16][17][18][19] . However, no study has focused exclusively on lung cancer patients, despite that cancer being one of the commonest in men and women alike 20,21 .…”

Section: Resultsmentioning

confidence: 99%

The Potential Role for Acupuncture in Treating Symptoms in Patients with Lung Cancer: An Observational Longitudinal Study

Kasymjanova

Grossman

Tran³

et al. 2013

Current Oncology

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was reported by 61% of patients for pain and by 33% for well-being.A significant positive correlation between improved well-being and the number of acupuncture sessions was observed. This correlation remained significant even after controlling for treatment and narcotic use. Receiver operating characteristic analysis demonstrated that a minimum of 6 acupuncture sessions are required for a 70% chance of a clinically important improvement in well-being. ConclusionsThe present study is the first to demonstrate that acupuncture may be an effective approach for improving symptoms-in particular, pain and well-being-in lung cancer patients. Acupuncture is a safe and minimally invasive procedure, and it is potentially useful even in patients undergoing anticancer treatment.

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Section: Resultsmentioning

confidence: 99%

The Potential Role for Acupuncture in Treating Symptoms in Patients with Lung Cancer: An Observational Longitudinal Study

Kasymjanova

Grossman

Tran³

et al. 2013

Current Oncology

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“…In addition to pain management, acupuncture has been shown to be effective for inhibiting one of the sympathetic pathways stimulated during chronic stress in rats 16 and reducing stress in elderly populations. 17 Few studies have examined the effectiveness of acupuncture for children with pain. 18,19 A combination of acupuncture and hypnosis was also found to be feasible and effective for decreasing pain and anxiety across six treatments in children and adolescents with chronic pain.…”

Section: Introductionmentioning

confidence: 99%

Examining the Association Between Parental Stress Related to Child Illness and Child Pain Across Acupuncture Treatments

MeyerRika¹,

BarberBeth²,

KobyleckaMonika³

et al. 2014

Medical Acupuncture

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Background: Pediatric chronic pain not only affects the child but also has a ripple effect on the entire family.While several studies have shown that acupuncture is beneficial for decreasing pain intensity in adults, few studies have examined the effectiveness of acupuncture in children and adolescence as well as the impact of acupuncture on the association between parent stress and child pain.Objective: This study examined whether two acupuncture treatments may help reduce child pain and parent stress as well as examining the bidirectional relationship between parent stress and child pain across the two treatments. Design: The study was a pre/post test design. Participants completed the Pediatric Inventory for Parents and Faces Pain Scale-Revised at baseline and at the conclusion of the second acupuncture treatment (at Time 2). Setting: Participants were recruited from a pain clinic at an academic pediatric hospital. Patients: Parent-child dyads (N = 29; M age = 14.13; standard deviation = 2.43) participated in the study. Results: Child pain and parent stress significantly decreased after two acupuncture treatments. Child pain significantly predicted parent stress frequency, difficulty, and stress frequency, while parent stress difficulty significantly predicted child pain at baseline. At T2, there was a bidirectional relationship between parent stress frequency, difficulty and child pain. Conclusions: These findings suggest that acupuncture is beneficial for reducing child pain and parent stress. The results also emphasize the bidirectional relationship between parent stress frequency and the child's perception of pain.

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“…In addition to analgesic evidence, clinical and experimental evidence has demonstrated that electroacupuncture (EA) treatment is effective for numerous immunological diseases, including infections, autoimmune diseases and immunodeficiency-syndromes (9,10). Previous evidence has suggested that EA may increase splenic lymphocyte proliferation and IL-2 production in rats following surgical trauma (11,12).…”

Section: Introductionmentioning

confidence: 99%

Electroacupuncture inhibits apoptosis of splenic lymphocytes in traumatized rats through modulation of the TNF-α/NF-κB signaling pathway

Wang

Meng

et al. 2014

Molecular Medicine Reports

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Surgical trauma leads to a severe deterioration of the immune system. Electroacupuncture (EA) may improve the immunodeficiency that occurs following surgery; however, the underlying signaling mechanisms require further study. In the present study, 40 rats were equally randomized into four groups: Control; Control + EA; Trauma; Trauma + EA. EA was applied at the 'Zusanli' (ST36) and 'Lanwei' (Extra37) acupoints, immediately following surgery. The splenic T cells were isolated from the rats 24 h after surgery. The apoptotic rate of the lymphocytes was measured by flow cytometric analysis, and western blotting was used to determine the protein expression levels of caspase-3, caspase-8, tumor necrosis factor (TNF)-α and TNF receptor 1 (TNFR1). The DNA binding activity of nuclear factor (NF)-κB was determined using Trans-AM® ELISA-based kits. The results of the present study showed that surgical trauma induced apoptosis of splenic lymphocytes, and significantly increased the protein expression levels of caspase-3 and caspase-8. This was accompanied by increased expression levels of TNF-α and TNFR1, and a marked reduction in the activity of NF-κB in splenic T cells. Administration of EA significantly decreased the expression levels of caspase-3, caspase-8, TNF-α and TNFR1, elevated the activity of NF-κB, and suppressed the apoptotic rate of the lymphocytes. The data suggests that EA may inhibit the apoptosis of splenic lymphocytes induced by surgical trauma, and ameliorate the postoperative immunosuppression. This may be mediated by the downregulation of TNF-α expression levels and upregulation of the activity of NF-κB.

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Acupuncture is effective to attenuate stress and stimulate lymphocyte proliferation in the elderly

Cited by 37 publications

References 19 publications

The Potential Role for Acupuncture in Treating Symptoms in Patients with Lung Cancer: An Observational Longitudinal Study

The Potential Role for Acupuncture in Treating Symptoms in Patients with Lung Cancer: An Observational Longitudinal Study

Examining the Association Between Parental Stress Related to Child Illness and Child Pain Across Acupuncture Treatments

Electroacupuncture inhibits apoptosis of splenic lymphocytes in traumatized rats through modulation of the TNF-α/NF-κB signaling pathway

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