Acupuncture in the Oncology Setting: Clinical Trial Update

Capodice, Jillian L.

doi:10.1007/s11864-010-0131-3

Cited by 15 publications

(4 citation statements)

References 27 publications

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“…Mao et al (2009) suggested that the decrease in psychological distress because of the endogenous serotonin modulation effects induced by acupuncture was a mediating factor in the resultant fatigue improvement. Similar mechanisms relating to modulation in the nervous or related systems have been suggested by authors for many other symptoms (Capodice, 2010;Sagar, 2008;Tsay, 2004).…”

Section: Discussionsupporting

confidence: 80%

“…Acupuncture and acupressure are potentially effective interventions for managing multiple symptoms simultaneously (Capodice, 2010;Lee & Frazier, 2011;Molassiotis et al, 2012;O'Regan & Filshie, 2010;Sagar, 2008). Studies of acupuncture or acupressure for other symptoms have revealed these concurrent effects as well (Tsay, 2004;Tsay, Cho, & Chen, 2004).…”

Section: Discussionmentioning

confidence: 99%

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Effects of Acupuncture and Acupressure on Cancer-Related Fatigue: A Systematic Review

Ling

Lui²,

et al. 2014

Oncology Nursing Forum

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Effects of Acupuncture and Acupressure on Cancer-Related Fatigue: A Systematic Review

Ling

Lui²,

et al. 2014

Oncology Nursing Forum

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“…Acupuncture is a CAM modality that shows promise as a component of supportive cancer care (6). In a survey study, close to half of breast cancer survivors want acupuncture to be offered in a comprehensive cancer center (5).…”

Section: Introductionmentioning

confidence: 99%

Breast cancer survivors willingness to participate in an acupuncture clinical trial: a qualitative study

Schapira

Mackenzie

Lam

et al. 2013

Support Care Cancer

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Purpose Acupuncture is a complementary and alternative medicine (CAM) modality that shows promise as a component of supportive breast cancer care. Lack of robust recruitment for clinical trial entry has limited the evidence-base for acupuncture as a treatment modality among breast cancer survivors. The objective of this study is to identify key decision making factors among breast cancer survivors considering entry into an acupuncture clinical trial for treatment of symptoms. Methods Semi-structured interviews were conducted among African-American (n=12) and Caucasian (n=13) breast cancer survivors. Verbatim transcripts were made and analyzed by two or more independent coders using NVivo software. Major recurring themes were identified and a theoretical framework developed. Results Six themes emerged reflecting key attributes of the decision to enter a clinical trial: 1) symptom appraisal, 2) practical barriers (e.g. distance, travel), 3) beliefs about the interventions (e.g. fear of needles, dislike of medications), 4) comfort with elements of clinical trial design (e.g., randomization, the nature of the control intervention, and blinding), 5) trust, and 6) altruism. African-American and Caucasian women weighed similar attributes but differed in the information sources sought regarding clinical trial entry and in concerns regarding the use of a placebo in a clinical trial. Conclusions We present of a theoretical framework of decision making for breast cancer survivors considering entry into a CAM clinical trial for symptom management. This framework can inform both research studies and programmatic initiatives to support a shared decision making process and robust recruitment to CAM trials among cancer survivors.

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“…Acupuncture has already been established as a safe and effective evidence-based treatment for a variety of symptoms commonly experienced by oncology patients (ie, pain, fatigue, anxiety, nausea and vomiting, xerostomia, etc.) 8,9 Several small studies have reported that acupuncture may also be an effective therapeutic option in the management of lymphedema, improving clinical symptoms and reducing limb volume. [10][11][12][13] The physiology of how acupuncture may improve lymphedema is not known.…”

Section: Acupuncture and Lymphedemamentioning

confidence: 99%

Acupuncture: Could an ancient therapy be the latest advance in the treatment of lymphedema?

Lawenda

Vicini

2013

Cancer

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The BackgroundOne of the most common complications of breast cancer treatment is lymphedema, an incurable condition that affects the lives of approximately 800,000 US breast cancer survivors.1,2 If not detected early and treated, clinical signs and symptoms can develop from the accumulation of lymphatic fluid in the tissues of the affected arm and remaining breast quadrant. Although established therapies for lymphedema management exist, there remains a need for other modalities that can further improve outcomes. Preliminary reports suggest that acupuncture may be a promising adjunctive therapeutic option. Defining the ProblemIn oncology, the most common cause of lymphedema (LE) is the impaired or disrupted flow of lymph fluid through the draining lymphatic vessels and lymph nodes, usually a consequence of surgery and/or radiation therapy to these tissues. Ultimately, this can lead to an accumulation of lymph fluid in the interstitial tissue, causing swelling. If LE remains untreated, this protein-rich fluid can continue to accumulate, leading to further swelling and fibrosis in the affected tissues. In this chronic state, there can be loss of limb function and range of motion, as well as an increased risk of pain, paresthesias, and infections. Although breast cancer-related lymphedema (BCRL) is responsible for the majority of the cases of LE after cancer treatment, LE can also result from treatment of other cancers (ie, cervical, endometrial, vulvar, head and neck, and prostate cancers, sarcomas, melanomas, etc.)The main risk factor for the development of LE is the extent to which the lymphatics are disturbed. For example, patients treated for breast cancer with both surgery and radiation therapy to the axilla have a risk of BCRL as high as 50%. In contrast, those who undergo only surgery to the axilla (without axillary radiation) have a risk of BCRL of 5%-20% depending on the technique (ie, sentinel lymph node biopsy, axillary lymph node dissection). 2Other risk factors have also been associated with BCRL, including infection, trauma, chemotherapy, hormonal therapy, obesity and larger breast size, and tumor location in the upper outer quadrant of the breast. 3It is important for patients, caregivers, and health care providers to recognize that BCRL can present at any time after treatment for breast cancer and to be aware of the signs and symptoms. Preventing the progression of BCRL is possible with continuous monitoring and early detection techniques and minimizing the risk factors for exacerbating LE.Unfortunately, there are no curative treatments for lymphedema yet available. 2,4 The goal of all LE treatments is to reduce the volume of excess interstitial lymph fluid as much as possible and maintain the limb at its smallest size. The existing treatments for LE become increasingly less effective in reducing limb swelling in later stages because as the condition progresses, fibrosis and adipose tissue permanently replace the excess interstitial lymph fluid. Diagnosing BCRLThe National Lymphedema Network (NLN) m...

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Acupuncture in the Oncology Setting: Clinical Trial Update

Cited by 15 publications

References 27 publications

Effects of Acupuncture and Acupressure on Cancer-Related Fatigue: A Systematic Review

Effects of Acupuncture and Acupressure on Cancer-Related Fatigue: A Systematic Review

Breast cancer survivors willingness to participate in an acupuncture clinical trial: a qualitative study

Acupuncture: Could an ancient therapy be the latest advance in the treatment of lymphedema?

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