Acupuncture Has a Positive Effect on Asthmatic Rats in a Glucocorticoid-Independent Manner

Wang, Wen-Qian; Xu, You‐Ping; Long-ping, Cui; Yin, Lei‐Miao; Wang, Yu; Liu, Yanyan; Yang, Yongqing

doi:10.1136/acupmed-2015-010934

“…Acupoint application has an advantage over other treatment therapies in treating asthma as acupoint stimulation promotes flow of blood to dispel pathogenic factors. This can stimulate the body's immunity and reduce allergic states [ 27 ]. But still, no fully revealed mechanism of acupoint application has been observed in the treatment of cough variant asthma.…”

Section: Discussionmentioning

confidence: 99%

[Retracted] Assessment of Acupoint Therapy of Traditional Chinese Medicine on Cough Variant Asthma: A Meta‐analysis

Tu

¹

,

Zhang

²

2022

BioMed Research International

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Acupoint application has been used in China to treat various illnesses for ages. In cough variant asthma (CVA), the main clinical sign is episodic night cough. Acupoint application therapy of traditional Chinese medicine is an effective procedure to treat cough variant asthma. The current study is designed to systematically assess the effectiveness of acupoint application therapy in traditional medicine for patients with cough variant asthma. The comprehensive computer retrieval related to comparison between acupoint application and nonacupoint application therapy for cough variant asthma was carried out in various databases ( n = 8 ) from database establishment until July 4, 2021. Both English and Chinese articles about original investigations in humans were searched. Two independent authors extracted the data, and disagreements were resolved by discussion. ReviewManager 5.3 software provided by Cochrane did a meta-analysis of selected randomized controlled trials (RCTs). Quality of experimentation and risk bias were analyzed by the Cochrane Handbook tool. A total of thirteen randomized controlled clinical articles along with 1237 patients were included in the study. Findings of meta-analysis showed that compared with nonacupoint application treatment, the total effective rate of acupoint application treatment is more effective ( RD = 0.13 , 95% CI (0.09, 0.17), Z = 6.70 , P < 0.00001 ). Besides, acupoint application can improve patients’ lung function, the lung function index FVC ( mean difference = 0.55 , 95% confidence interval (0.42, 0.68), Z = 8.40 , P < 0.00001 ), FEV1 ( MD = 0.35 , 95% CI (0.23, 0.47), Z = 5.86 , P < 0.00001 ), FEV1/FVC (%) ( MD = 12.68 , 95% CI (4.32, 21.03), Z = 2.97 , P = 0.003 ), FEV1 (%) ( MD = 8.63 , 95% CI (8.01, 9.25), Z = 27.44 , P < 0.00001 ), and PEF (day) ( MD = 0.62 , 95% CI (0.52, 0.71), Z = 12.40 , P < 0.00001 ) of patients treated by acupoint application therapy were increased. Moreover, acupoint application might lower the level of immunoglobulin E ( MD = − 54.58 , 95% CI (−63.54, −45.61), Z = 11.93 , P < 0.00001 ) and EOS ( MD = − 0.21 , 95% CI (−0.35, −0.06), Z = 2.77 , P = 0.006 ). The LCQ (Leicester cough questionnaire) total score of CVA patients was also increased ( MD = 2.30 , 95% CI (1.55, 3.06), Z = 5.98 , P < 0.00001 ). Acupoint application therapy is effective in controlling symptoms of CVA. It also has a positive effect in improving lung function and life quality of patients. It can reduce the eosinophil levels and peripheral blood IgE levels of patients as well.

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“…[20] Acupuncture has important potential and advantages in treating cough-variant asthma. Numerous [22,23].…”

Section: Discussionmentioning

confidence: 99%

Acupuncture Treatment for Cough-Variant Asthma: A Meta-Analysis

Xiong

¹

,

Qi

²

,

Zou

³

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Background. In recent years, there have been many clinical reports on acupuncture treatment of cough-variant asthma, but no researcher has objectively analysed and evaluated the efficacy and safety of acupuncture treatment of cough-variant asthma from the perspective of evidence-based medicine. Objective. To systematically evaluate the clinical efficacy and safety of acupuncture in treating cough-variant asthma and to provide reference values for clinical decision-making. Methods. The comprehensive computer retrieval Chinese journal full-text database (CNKI), Chinese science and technology periodical database (VIP), ten thousand data knowledge service platform (WanFang Data), PubMed, Embase, and the Cochrane Library were used to collect literature for relevant randomized controlled trials (RCT) of acupuncture treatment of cough-variant asthma, as well as to retrieve papers and add reference retrieval after literature review, in accordance with the standard of literature filtering, data extraction, and quality evaluation. The data were meta-analysed using ReviewManager5.3 software recommended by Cochrane. Results. A total of 11 randomized controlled clinical studies were screened and included, comprising 929 patients. The results of the meta-analysis showed that, compared with the control group, acupuncture intervention on CVA could enhance the total clinical effectiveness rate, reduce the relapse rate of drug withdrawal, relieve symptoms of cough, phlegm, and diaphragmatic congestion, and improve lung function-related indicators and immune inflammation indicators. There were statistically significant differences in all efficacy evaluation criteria. Conclusion. The clinical curative effect of acupuncture treatment for cough-variant asthma is precise and has certain advantages in relieving symptoms and reducing the recurrence rate. However, the low quality of the evaluation in the RCT research literature is a problem, and more high-quality clinical randomized controlled trials are needed to further verify the comprehensive clinical efficacy and safety of this treatment. Registration number: PROSPERO (no. CRD42020155244) (https://www.crd.york.ac.uk/prospero/).

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“…Acupuncture at GV14, BL13, and BL12 can recover the levels of ACTH and CORT in serum based on the reduction of ACTH and CORT induced by asthma. 97,98 The acupoint formula including BL13, BL12, and GV14 is a common formula in clinical practice, and the latest research has revealed that stimulation of these acupoints can enhance the FC between the right insula subregions and the brain regions related to default mode network in asthma patients, providing evidence for the effects of acupuncture therapy for asthma from the perspective of neuroscience. 32 ST36, BL23, CV17, and EX-B1 are essential auxiliary acupoints to enhance the acupoint formula efficacy.…”

Section: Hormonesmentioning

confidence: 99%

Research on the Mechanism and Application of Acupuncture Therapy for Asthma: A Review

Wang,

Jin

2024

JAA

0

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Asthma is a high-risk disease based on airway hyperresponsiveness (AHR). In this review, we found that there are many studies on clinical therapy for asthma that focus on the efficacy of acupuncture therapy and its mechanisms, including the functional connectivity of different brain regions, with the aid of functional magnetic resonance imaging (fMRI), immune responses/cell recognition (innate lymphoid cells and balance of Th1/Th2 and Treg/Th17), intracellular mechanism (autophagy, endoplasmic reticulum stress, and epigenetic alteration), and ligand-receptor/chemical signaling pathway (neurotransmitter, hormone, and small molecules). In this review, we summarized the clinical and experimental evidence for the mechanisms of acupuncture therapy in asthma to offer insights into drug discovery and clinical therapy. Given the paucity of clinical studies on the mechanisms of acupuncture in the treatment of asthma, this review notably included studies based on animal models to investigate the mechanisms of acupuncture in the treatment of asthma.

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Acupuncture Has a Positive Effect on Asthmatic Rats in a Glucocorticoid-Independent Manner

Cited by 8 publications

References 22 publications

[Retracted] Assessment of Acupoint Therapy of Traditional Chinese Medicine on Cough Variant Asthma: A Meta‐analysis

[Retracted] Assessment of Acupoint Therapy of Traditional Chinese Medicine on Cough Variant Asthma: A Meta‐analysis

Acupuncture Treatment for Cough-Variant Asthma: A Meta-Analysis

Research on the Mechanism and Application of Acupuncture Therapy for Asthma: A Review

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