Acupuncture for vascular dementia

Peng, WN; Zhao, Hong; Liu, ZS; Wang, S

doi:10.1002/14651858.cd004987

Cited by 20 publications

(21 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Acupuncture is a nonpharmacological therapy that has been extensively tested in patients with VaD in China . Several clinical studies have shown therapeutic benefits of acupuncture in patients with VaD .…”

Section: Introductionmentioning

confidence: 99%

Acupuncture as a multifunctional neuroprotective therapy ameliorates cognitive impairment in a rat model of vascular dementia: A quantitative iTRAQ proteomics study

et al. 2018

View full text Add to dashboard Cite

Aims: Acupuncture has been reported to affect vascular dementia through a variety of molecular mechanisms. An isobaric tag for relative and absolute quantification (iTRAQ) with high-resolution liquid chromatography-tandem mass spectrometry (LC-MS/MS) analyses makes it possible to attain a global profile of proteins. Hence, we used an iTRAQ-LC-MS/MS strategy to unravel the underlying mechanism of acupuncture.Methods: Wistar rats were subjected to vascular dementia with bilateral common carotid occlusion. Acupuncture was intervened for 2 weeks at 3 days after surgery.The Morris water maze was used to assess the cognitive function. Proteins were screened by quantitative proteomics and analyzed by bioinformatic analysis. Four differentially expressed proteins (DEPs) were validated by western blot. The reactive oxygen species (ROS) production, neuron cell loss, and long-term potentiation (LTP) were determined after western blot.Results: Acupuncture at proper acupoints significantly improved cognitive function.A total of 31 proteins were considered DEPs. Gene ontology (GO) analysis showed that most of the DEPs were related to oxidative stress, apoptosis, and synaptic function, which were regarded as the major cellular processes related to acupuncture effect. Western blot results confirm the credibility of iTRAQ results. Acupuncture could decrease ROS production, increase neural cell survival, and improve LTP, which verified the three major cellular processes. Conclusion: Acupuncture may serve as a promising clinical candidate for the treatment of vascular dementia via regulating oxidative stress, apoptosis, or synaptic functions. K E Y W O R D S acupuncture, iTRAQ, proteomics, vascular dementia 1 | INTRODUC TI ON Vascular dementia (VaD) as the second most common cognitive disorders, following Alzheimer's disease (AD), is caused by a series of cardiac-cerebral vascular conditions that are characterized by loss of cognitive functions. 1,2 The worldwide number of patients with VaD is estimated to rise because no effective prevention or treatment strategy is available. 3 Progress toward finding effective treatments for VaD S U PP O RTI N G I N FO R M ATI O N Additional supporting information may be found online in the Supporting Information section at the end of the article. How to cite this article: Yang J-W, Wang X-R, Zhang M, et al. Acupuncture as a multifunctional neuroprotective therapy ameliorates cognitive impairment in a rat model of vascular dementia: A quantitative iTRAQ proteomics study. CNS

show abstract

Section: Introductionmentioning

confidence: 99%

Acupuncture as a multifunctional neuroprotective therapy ameliorates cognitive impairment in a rat model of vascular dementia: A quantitative iTRAQ proteomics study

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Vascular dementia (VD), the second most common cause of dementia, is a disease that has a detrimental impact on learning and memory [1][2][3][4]. Most VD treatments that are currently available are designed to slow the progression of the disease [5][6][7][8], rather than stimulate repair and recovery.…”

Section: Introductionmentioning

confidence: 99%

Hyperbaric oxygen therapy improves neurogenesis and brain blood supply in piriform cortex in rats with vascular dementia

Zhang¹,

Yang²,

Wang³

et al. 2010

Brain Injury

View full text Add to dashboard Cite

show abstract

“…(2001) went further suggesting that acupuncture was a ‘better intervention’ for VaD than drugs and other medications. On the other hand, a systematic review of acupuncture conducted by Peng et al. (2007) suggests that the effectiveness of acupuncture for VaD is uncertain, and as there was an absence of suitable randomised controlled trials of high quality further randomised double‐blind placebo controlled trials are recommended.…”

Section: Resultsmentioning

confidence: 99%

Systematic review: role of health promotion in vascular dementia

Price¹,

Keady²

2010

J of Nursing and Healthcare

View full text Add to dashboard Cite

price rs & keady j (2010) Journal of Nursing and Healthcare of Chronic Illness 2, 88–101 Systematic review: role of health promotion in vascular dementia Aims. This narrative synthesis of the literature investigates the areas of vascular dementia and modifiable risk factors in order to identify the evidence base and opportunities for specific health promotion work and nursing involvement. Background. Strategies for well‐being, prevention and health promotion are becoming increasingly important determinants of a quality dementia care service. In England, this emphasis is manifest in the recently launched National Dementia Strategy (February 2009) and areas that address modifiable vascular risk factors are helpful starting points for the enactment of such goals. Design and methods. A comprehensive search strategy identified primary and secondary search terms that were used systematically in order to search for relevant information and literature; 128 articles were finally included in the overall design and these were broken down into 116 articles obtained through the formal search process using the online databases and 12 articles from the ‘grey literature’. Results. A narrative synthesis of the included material generated a thematic framework that revealed four discrete but overlapping themes: vascular risk factors (1); prevention and reduction of vascular risk factors (2); treatment and intervention in vascular dementia (3); and vascular health promotion (4). Relevance to clinical practice. Nursing is in a prime position to undertake health promotion initiatives in modifiable risk behaviours in vascular dementia, an approach that should be commenced for the general population in mid‐life (50 years and over).

show abstract

Acupuncture for vascular dementia

Cited by 20 publications

References 34 publications

Acupuncture as a multifunctional neuroprotective therapy ameliorates cognitive impairment in a rat model of vascular dementia: A quantitative iTRAQ proteomics study

Acupuncture as a multifunctional neuroprotective therapy ameliorates cognitive impairment in a rat model of vascular dementia: A quantitative iTRAQ proteomics study

Hyperbaric oxygen therapy improves neurogenesis and brain blood supply in piriform cortex in rats with vascular dementia

Systematic review: role of health promotion in vascular dementia

Contact Info

Product

Resources

About