Acupuncture for the Treatment of Peripheral Neuropathy: A Systematic Review and Meta-Analysis

Dimitrova, Alexandra; Murchison, Charles; Oken, Barry

doi:10.1089/acm.2016.0155

Cited by 180 publications

(108 citation statements)

References 69 publications

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“…One of 2 well‐designed RCTs of acupuncture for Bell's palsy showed improvement compared with standard medical treatment, and in the other RCT, all groups, including the control group, had high improvement rates, resulting in a negative study. The discrepancy was thought to be due to the heterogeneous but generally favorable prognosis of this condition . The current state of evidence also shows that acupuncture may be beneficial in HIV neuropathy, but further study is needed in this condition as well as in idiopathic neuropathy and CIPN.…”

Section: Acupuncturementioning

confidence: 96%

“…A systematic review and meta‐analysis of acupuncture for the treatment of peripheral neuropathy evaluated 15 studies, including 13 RCTs and 2 follow‐up studies to RCTs evaluating acupuncture for neuropathy secondary to diabetes, Bell's palsy, CTS, HIV, and idiopathic neuropathy (see Table S1 online). Most studies originated in China and the USA, with the majority of RCTs showing benefit of acupuncture or acupuncture plus usual medical care over sham acupuncture or usual medical care alone for diabetic neuropathy and CTS . One of 2 well‐designed RCTs of acupuncture for Bell's palsy showed improvement compared with standard medical treatment, and in the other RCT, all groups, including the control group, had high improvement rates, resulting in a negative study.…”

Section: Acupuncturementioning

confidence: 99%

“…Most studies originated in China and the USA, with the majority of RCTs showing benefit of acupuncture or acupuncture plus usual medical care over sham acupuncture or usual medical care alone for diabetic neuropathy and CTS. 153 One of 2 well-designed RCTs of acupuncture for Bell's palsy showed improvement compared with standard medical treatment, and in the other RCT, all groups, including the control group, had high improvement rates, resulting in a negative study. The discrepancy was thought to be due to the heterogeneous but generally favorable prognosis of this condition.…”

Section: Acupuncturementioning

confidence: 99%

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Integrative neuromuscular medicine: Neuropathy and neuropathic pain: Consider the alternatives

Rowin

2019

Muscle and Nerve

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Complementary and alternative treatment modalities are commonly utilized by patients for neuropathy and neuropathic pain due to perceived lack of benefit from conventional medical treatment. As the association between metabolic syndrome and neuropathy is increasingly recognized, diet and lifestyle interventions are becoming important components in the management of neuropathy. Progress in the understanding of the gut–immune interaction highlights the role the gut microbiome and inflammation plays in the modulation of neuropathy and neuropathic pain. Evidence for nutritional interventions, exercise, supplements, acupuncture, and mindfulness‐based practices in the treatment of neuropathic pain is encouraging. This article reviews the available evidence to support the safe use of complementary and alternative treatments for commonly encountered conditions associated with neuropathy and neuropathic pain. Muscle Nerve 60: 124–136, 2019

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Section: Acupuncturementioning

confidence: 96%

Section: Acupuncturementioning

confidence: 99%

Section: Acupuncturementioning

confidence: 99%

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Integrative neuromuscular medicine: Neuropathy and neuropathic pain: Consider the alternatives

Rowin

2019

Muscle and Nerve

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“…These structural particularities might be involved in the electrophysiological response under specific stimulation. Moreover, when acupoints are coincident with or located nearby peripheral nerves, they are commonly used successfully in the treatment of peripheral neuropathy, suggesting that acupuncture induces vegetative changes in the tissue and, thereby, improvements in the electrical properties of the affected nerves [14,15,[39][40][41][42][43][44].…”

Section: Discussionmentioning

confidence: 99%

Assessment of Acupuncture and Moxibustion Effects on the Electrophysiological Properties of the Ulnar Nerve: A Nerve Conduction Study

et al. 2018

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Background/Aims: Acupuncture and moxibustion, when used together, have act mechanically and thermally on treated reflexological areas. The main goal of this work was to evaluate the effects of acupuncture and moxibustion on the electrophysiological properties of the ulnar nerve. Methods: Electrical stimulation was applied to the ulnar nerve above the epicondyle of 28 volunteers. A 20-V potential was applied, and after each 10 impulses it was increased by 10 V, up to a maximum of 80 V. At 20 and 80 V, the participants were asked to rate the discomfort from 0 to 10 on a Numeric Rating Scale for pain. After the first stimulation and data collection, the control group rested for 6 min, while the intervention group was submitted to acupuncture and moxibustion on Lingdao (HT 4). Following this period of time, a second electrical stimulation was performed on both groups. Results: The discomfort was greater in the intervention group during the second stimulation. The stimulus required to achieve the maximum amplitude decreased, but the changes were only statistically significant in the intervention group (p = 0.006). An increase in latency and a decrease in reaction velocity were noticed between the first and the second stimulation for both groups; however, only the control group presented statistically significant differences (p = 0.018 and p = 0.022, respectively). Conclusions: Acupuncture and moxibustion on HT 4 increased the electrical sensitivity, decreased the stimulus intensity to achieve the maximum amplitude, and avoided a significant increase in latency and decrease in reaction velocity in two consecutive electrical stimulations.

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“…While topical analgesics have been reported to have similar effects on pain reduction with less systemic side effects compared to systemic pharmacotherapy, their use is limited by low patient compliance with application and limited efficacy [10,11]. Electrical nerve stimulation, acupuncture, electro acupuncture, cognitive behavioral therapy, biofeedback, and physical therapy have also been reported to reduce painful DSPN [12][13][14][15][16][17][18][19]. …”

Section: Introductionmentioning

confidence: 99%

A Randomized, Sham-Controlled, Double-Blind Pilot Study of Pulsed Electromagnetic Field Therapy to Evaluate Small Fiber Nerve Growth and Function and Skin Perfusion in Subjects with Painful Peripheral Diabetic Neuropathy

Aj¹,

Rp²,

Muhlenfeld³

et al. 2017

J Diabetic Complications Med

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Abstract:Purpose: The objective of this study was to determine the potential efficacy and safety of dual energy pulsed electromagnetic field therapy (PEMF) on painful distal symmetric diabetic sensorimotor polyneuropathy (DSPN).Methodology: Subjects with Type 2 diabetes and painful DSPN were randomized to receive either an active or sham PEMF device. Objective measures of efficacy (skin biopsy, nerve conduction velocity (NCV) studies, dorsal and plantar foot skin perfusion pressure (SPP) were performed prior to and following 60-days of twice daily 30 minute treatments. Patient reported outcomes included perception of pain, concomitant medication use and adverse events.Major findings: Dorsal foot SPP improved with PEMF (n=11), change from baseline=19.6 mmHg) vs. sham (n=7, change=-17.4 mmHg), p=0.03. Trends in favor of PEMF vs sham were observed for medial nerve (n=4), planter nerve (n=4) and sural nerve (n=15) onset time and amplitude (p>0.05) other than medial planter onset time (p=0.04). Although change in pain scores were similar, compliance with device use was higher in the active group compared to the sham control. The series of tests and long-term use of PEMF was well-tolerated and feasible. No device related adverse effects were recorded.Principal conclusions: Twice daily PEMF therapy was feasible, well-tolerated, and associated with trends suggesting improved nerve function and microcirculation in patients with painful DSPN. Future, large randomized controlled trials are necessary to confirm these findings and evaluate the potential longer term benefits on symptoms and pathology of DSPN.Keywords: Diabetes; Nerve conduction velocity; Peripheral neuropathy; Pulsed electromagnetic field; Skin biopsy; Skin perfusion pressure Key MessagesPainful diabetic neuropathy affects the majority of patients with diabetes during their lifetime. The presence of diabetic neuropathy increases the potential for diabetes-related lower extremity complications.The aim of this randomized, sham-controlled trial was to determine the feasibility and effects of 60 days of treatment with PEMF therapy on skin perfusion, nerve growth and function as well as pain perception, compliance and safety in subjects with painful diabetic neuropathy. Nineteen patients (12 active; 7 sham) participated in this study.This pilot study demonstrated feasibility of use and trends in favor of PEMF in nerve function and skin perfusion of the dorsal foot. Although a reduction in average pain intensity score was not observed, subjects in the active group were relatively more compliant with device use. No device adverse effects were reported.

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Acupuncture for the Treatment of Peripheral Neuropathy: A Systematic Review and Meta-Analysis

Abstract: Acupuncture is beneficial in some peripheral neuropathies, but more rigorously designed studies using sham-acupuncture control are needed to characterize its effect and optimal use better.

Cited by 180 publications

References 69 publications

Integrative neuromuscular medicine: Neuropathy and neuropathic pain: Consider the alternatives

Integrative neuromuscular medicine: Neuropathy and neuropathic pain: Consider the alternatives

Assessment of Acupuncture and Moxibustion Effects on the Electrophysiological Properties of the Ulnar Nerve: A Nerve Conduction Study

A Randomized, Sham-Controlled, Double-Blind Pilot Study of Pulsed Electromagnetic Field Therapy to Evaluate Small Fiber Nerve Growth and Function and Skin Perfusion in Subjects with Painful Peripheral Diabetic Neuropathy

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