Acupuncture for the Treatment of Hiccups following Stroke: A Systematic Review and Meta-Analysis

Yue, Jin; Liu, Ming; Li, Jun; Wang, Yuming; Hung, E-Sing; Tong, Xin; Sun, Zhaoqing; Zhang, Qinhong; Golianu, Brenda

doi:10.1136/acupmed-2015-011024

Cited by 25 publications

(18 citation statements)

References 27 publications

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“…A systematic review and meta-analysis of acupuncture treatment for patients suffering from intractable hiccups suggested some benefit when used as an adjunct to medical therapy 46. However, a number of researchers have indicated that definitive conclusions and strong evidence of efficacy was not obtainable due to the limited number of randomised controlled studies and poor methodologies.…”

Section: Treatment Of Hiccupsmentioning

confidence: 99%

Management of hiccups in palliative care patients

Jeon

Kearney

Baker

2017

BMJ Support Palliat Care

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Persistent hiccups are a frustrating experience for palliative care patients, and can have a profound impact on their quality of life. This article provides an evidence-based approach overview of the causes and treatment of this not infrequently debilitating condition for such patients, with a management algorithm. In situations where no readily reversible cause is identified, or where simple physical manoeuvres, such as breath holding have failed, a systematic approach is required. Hiccups can be broadly divided into central and peripheral types. These respond differently to pharmacological intervention. The drug of choice for central causes of persistent hiccups is baclofen, with metoclopramide recommended as the first choice for peripheral causes. Midazolam may be useful in cases of terminal illness. Interventional procedures such as vagal or phrenic nerve block or stimulation should be considered in patients who are refractory to medications. The management of persistent hiccups still presents an ongoing clinical challenge however, requiring further research on pathophysiology and treatment strategies. Multinational randomised controlled trials to evaluate and compare both current and new medications or procedures to better manage this difficult condition are suggested as a means of reaching this goal.

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Section: Treatment Of Hiccupsmentioning

confidence: 99%

Management of hiccups in palliative care patients

Jeon

Kearney

Baker

2017

BMJ Support Palliat Care

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“…11 Numerous clinical studies have demonstrated the effects of acupuncture in acute ischaemic stroke and its sequelae, such as hiccups, cognitive impairment and depression. 12–14 Meanwhile, animal studies have shown that acupuncture plays a neuroprotective role in cerebral ischaemia/reperfusion rats. 15,16 However, the effects of acupuncture are controversial because the mechanism is unclear.…”

Section: Introductionmentioning

confidence: 99%

Acupuncture attenuates cognitive impairment, oxidative stress and NF-κB activation in cerebral multi-infarct rats

Yang

Wang

et al. 2019

Acupunct Med

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Backgroud: Patients with multiple infarct dementia (MID) have subtle deficits that commonly go unnoticed, and are at risk of developing Alzheimer’s disease. Oxidative stress induced by ischaemic injury results in intracellular calcium accumulation and neuronal apoptosis, leading to cognitive impairment by triggering various cellular signal transduction pathways. Several studies have suggested that NF-κB in the presence of p53 has a pro-apoptotic function in various models, but the mechanism is unclear. Aims: The aim of this study was to investigate whether acupuncture could protect cognitive function against cerebral multi-infarction (CMi) induced oxidative stress by inhibiting the activation of NF-κB and its target gene p53. Methods: An animal model of CMi was established by injecting homologous blood emboli into the right internal carotid artery of male Wistar rats. After 2 weeks of acupuncture treatment, cognitive function was detected by novel object recognition. Electron spin resonance and Fluo-3 fuorescence imaging were used to test the generation of ROS and intracellular calcium accumulation, respectively. Expression of NF-κB and p53 was examined by Western blot analysis and immunofluorescence. Results: CMi induced spatial learning and memory impairment, overproduction of intracellular hydroxyl radicals, and elevations of Ca2+, which were ameliorated by verum acupuncture treatment. Acupuncture inhibited activation of NF-κB and its downstream target gene p53. Conclusion: These findings suggest that acupuncture could protect cognitive function against oxidative stress induced by CMi, which is partially associated with suppression of NF-κB-p53 activation.

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“…However, there is a lack of a uni ed diagnostic method and treatment for intractable hiccups in the world. An increasing number of studies have reported that, [27] acupuncture can be used as a type of gastrointestinal response in the treatment of some pathological diseases to improve the quality of life of patients, such as intractable hiccups caused by stroke [20] or postoperative tumors. [28] Acupuncture applied at intractable hiccups points and the methods are diverse, and have obvious advantages of improving the curative effect and shortening the course of the disease.…”

Section: Discussionmentioning

confidence: 99%

“…[13][14][15][16][17][18][19] Previous studies have also suggested that acupuncture is effective as an adjunct replacement therapy for intractable hiccups after stroke. [20] A systematic review of Cochrane included four RCTs evaluating the effectiveness of different acupuncture treatments for intractable hiccups. [21] Although all four studies suggested that acupuncture is effective in the treatment of intractable hiccups, it is unfortunate that none of the four studies provided a placebo control group, nor did they explain the side effects and complications.…”

Section: Description Of the Interventionmentioning

confidence: 99%

Efficacy of Acupuncture for Persistent and Intractable Hiccups: A Protocol for Systematic Review and Meta Analysis of Randomized Controlled Trials

Jiang

Wang

He³

et al. 2020

Preprint

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Background: Persistent and intractable hiccups are a common clinical symptom that cause considerable physical pain to patients and severely damage their quality of lives. An increasing number of studies have demonstrated that acupuncture applied at acupoints dominated by Cuanzhu (BL2) can be used as one of the nonpharmacological therapies for controlling intractable hiccups. However, there is insufficient evidence evaluating the safety and effectiveness of those interventions. Therefore, this study is intended to conduct a systematic review and meta-analysis to provide evidence for a further study investigating alternative treatment options for persistent and intractable hiccups.Methods: Randomized controlled trials (RCTs) of adult patients aged >18 years who meet the criteria for intractable hiccup diagnosis will be included, regardless of gender, nationality, and education level. Eight electronic databases will be searched, including four Chinese databases (CNKI, SinoMed, Wanfang Database, and Chinese Scientific Journal Database), four English databases (Web of Science, Medline, Embase, and Cochrane Library), from their date of establishment to September 2020. Two independent reviewers will evaluate the title summary for each RCT. Disagreements will be discussed with a third commentator. Data integration, heterogeneity analysis, subgroup analysis, and sensitivity analysis, will be performed using R-3.3.2 software. The RevMan 5.3 software will be used for the meta-analysis, and the “risk of bias” assessment will be conducted based on the methodological quality of the included trials recommended by the Cochrane Handbook 5.1. The quality evaluation of this study will be completed by the Grading of Recommendations, Assessment, Development, and Evaluation.Discusstion: This systematic review will provide evidence to assess the validity and safety of applying acupuncture at acupoints dominated by Cuanzhu (BL2) for persistent and intractable hiccups, which may provide clinicians with more choices in the treatment of this disease.Systematic review registration: PROSPERO CRD42020114900

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Acupuncture for the Treatment of Hiccups following Stroke: A Systematic Review and Meta-Analysis

Cited by 25 publications

References 27 publications

Management of hiccups in palliative care patients

Management of hiccups in palliative care patients

Acupuncture attenuates cognitive impairment, oxidative stress and NF-κB activation in cerebral multi-infarct rats

Efficacy of Acupuncture for Persistent and Intractable Hiccups: A Protocol for Systematic Review and Meta Analysis of Randomized Controlled Trials

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