Acupuncture for the treatment of thalamencephalic and mesencephalic injury secondary to electrical trauma: A case report

Jiang, Hailun; Zhang, Yi; Zhang, Jieying; Li, Boxuan; Zhu, Weiming; Liu, Chaoda; Deng, Shizhe; Du, Yiqin; Meng, Zhihong

doi:10.3389/fnins.2023.1139537

Cited by 5 publications

(5 citation statements)

References 39 publications

(38 reference statements)

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“…Before treating pain, traditional Chinese medicine such as acupuncture had been widely used to treat a wide range of ailments, and it has shown good results in different aspects. For example, within the realms of diabetes and neurological disorders, acupuncture exhibits remarkable advantages (33)(34)(35)(36). Network meta-analyses have previously explored traditional Chinese medicine interventions, including acupuncture (37).…”

Section: Discussionmentioning

confidence: 99%

Therapeutic efficacy of acupuncture point stimulation for stomach cancer pain: a systematic review and meta-analysis

Zhou,

Zhang,

Jiang

et al. 2024

Front. Neurol.

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PurposeIn recent years, traditional Chinese medicine has received widespread attention in the field of cancer pain treatment. This meta-analysis is the first to evaluate the effectiveness and safety of acupuncture point stimulation in the treatment of stomach cancer pain.MethodsFor this systematic review and meta-analysis, we searched PubMed, Web of Science, Cochrane Library, Embase, WANFANG, China National Knowledge Infrastructure (CNKI), and Chinese Journal of Science and Technology (VIP) databases as well as forward and backward citations to studies published between database creation to July 27, 2023. All randomized controlled trials (RCTs) on acupuncture point stimulation for the treatment of patients with stomach cancer pain were included without language restrictions. We assessed all outcome indicators of the included trials. The evidence from the randomized controlled trials was synthesized as the standardized mean difference (SMD) of symptom change. The quality of the evidence was assessed using the Cochrane Risk of Bias tool. This study is registered on PROSPERO under the number CRD42023457341.ResultsEleven RCTs were included. The study included 768 patients, split into 2 groups: acupuncture point stimulation treatment group (n = 406), medication control group (n = 372). The results showed that treatment was more effective in the acupuncture point stimulation treatment group than in the medication control group (efficacy rate, RR = 1.63, 95% CI 1.37 to 1.94, p < 0.00001), decreasing in NRS score was greater in acupuncture point stimulation treatment group than in the medication control group (SMD = −1.30, 95% CI −1.96 to −0.63, p < 0.001).Systematic Review Registrationhttps://clinicaltrials.gov/, identifier CRD42023457341.

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Section: Discussionmentioning

confidence: 99%

Therapeutic efficacy of acupuncture point stimulation for stomach cancer pain: a systematic review and meta-analysis

Zhou,

Zhang,

Jiang

et al. 2024

Front. Neurol.

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“…These inflammatory mediators disrupt gut barrier function and microbial balance, further exacerbating the inflammatory state, impacting stroke recovery, and promoting the development of PSD. In addition, PSD is also influenced by both brain ischemic injury and chronic stress, which interfere with normal gut function, leading to digestive system disorders including changes in intestinal motility, damaged mucosal barriers, and dysbiosis (Jiang et al., 2023). Gut microbiota produces various signaling molecules and metabolites, such as neurotransmitters, hormones, and short‐chain fatty acids (SCFAs) (Panther et al., 2022).…”

Section: Discussionmentioning

confidence: 99%

Inulin alters gut microbiota to alleviate post‐stroke depressive‐like behavior associated with the IGF‐1‐mediated MAPK signaling pathway

Shao,

Tan,

Pan

et al. 2024

Brain and Behavior

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IntroductionGut microbiota dysbiosis is a key factor of the pathogenesis of post‐stroke depression (PSD). PSD is associated with increased hippocampal neuronal apoptosis and decreased synaptic connectivity. Inulin can be involved in hippocampal neuron protection through the microbiome–gut–brain axis. However, the neuroprotective effects of inulin in PSD are still to be further investigated.MethodsBy utilizing the GEO public database, we identify differentially expressed genes in the hippocampus following inulin intake. This can help us discover key signaling pathways through functional enrichment analysis. Furthermore, we validate the expression levels of signaling molecules in a rat model of PSD and examine the effects of inulin on behavioral changes and body weight. Additionally, conducting a microbiome analysis to identify significantly different microbial populations and perform correlation analysis.ResultsThe intake of inulin significantly up‐regulated mitogen‐activated protein kinase signaling pathway in the hippocampus. Inulin changed in the gut microbiota structure, leading to an increase in the abundance of Lactobacillus and Clostridium_sensu_stricto_1 in the intestines of PSD rats, while decreasing the abundance of Ruminococcus UCG_005, Prevotella_9, Oscillospiraceae, and Clostridia UCG_014. Furthermore, the inulin diet elevated levels of insulin‐like growth factor 1 in the serum, which showed a positive correlation with the abundance of Lactobacillus. Notably, the consumption of inulin‐enriched diet increased activity levels and preference for sugar water in PSD rats, while also reducing body weight.ConclusionThese findings highlight the potential therapeutic benefits of inulin in the management of depression and emphasize the importance of maintaining a healthy gut microbiota for PSD.

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“…The pharmacological landscape for PSD is also being reshaped by insights into adiponectin's role in neuronal health, offering avenues to modulate inflammatory responses and alleviate depressive symptoms post-stroke through neuroplasticity regulation [249]. Furthermore, the gut-brain axis emerges as a critical factor in PSD, with gut microbiota imbalances linked to both psychiatric and gastrointestinal symptoms in PSD patients, positioning microbiota management as a potential therapeutic target 21 [250]. rTMS represents an innovative rehabilitative approach with variable efficacy across PSD patients, underscoring the need for optimized stimulation protocols and targeted therapeutic strategies [251].…”

Section: Challenges and Future Directionsmentioning

confidence: 99%

Inflammatory Pathogenesis of Post-stroke Depression

2024

Aging dis

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Post-stroke depression (PSD) is a complex mood disorder that emerges in individuals following a stroke, characterized by the development of depressive symptoms. The pathogensis of PSD is diverse, with inflammation playing a vital role in its onset and progression. Emerging evidence suggests that microglial activation, astrocyte responses, nuclear factor κB(NF-κB) signaling, dysregulation of the hypothalamic pituitary adrenal (HPA) axis, alterations in brain-derived neurotrophic factor (BDNF) expression, neurotransmitter imbalances, adenosine triphosphate (ATP) and its receptors and oxidative stress are intricately linked to the pathogenesis of PSD. The involvement of inflammatory cytokines in these processes highlights the significance of the inflammatory pathway. Integrating these hypotheses, the inflammatory mechanism offers a novel perspective to expand therapeutic strategies for PSD.

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Acupuncture for the treatment of thalamencephalic and mesencephalic injury secondary to electrical trauma: A case report

Cited by 5 publications

References 39 publications

Therapeutic efficacy of acupuncture point stimulation for stomach cancer pain: a systematic review and meta-analysis

Therapeutic efficacy of acupuncture point stimulation for stomach cancer pain: a systematic review and meta-analysis

Inulin alters gut microbiota to alleviate post‐stroke depressive‐like behavior associated with the IGF‐1‐mediated MAPK signaling pathway

Inflammatory Pathogenesis of Post-stroke Depression

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