Acupuncture for Histamine-Induced Itch: Association With Increased Parasympathetic Tone and Connectivity of Putamen-Midcingulate Cortex

Min, Seorim; Kim, Koh-Woon; Jung, Won-Mo; Lee, Min-Jung; Kim, Kyuseok; Chae, Younbyoung; Lee, Hyangsook; Park, Hi-Joon

doi:10.3389/fnins.2019.00215

Cited by 24 publications

(19 citation statements)

References 97 publications

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“…Based on anecdotal reports in humans, the potential utility of various complementary treatment modalities remains to be elucidated more clearly in the future, e.g. regarding the 755 nm alexandrite laser, botulinum toxin, acupuncture, transcranial magnetic stimulation, extracorporeal shockwave therapy, massage with violet oil, positive verbal suggestions or music therapy [223][224][225][226][227][228][229][230][231].…”

Section: Miscellaneous Modalitiesmentioning

confidence: 99%

Emerging Therapeutic Options for Chronic Pruritus

2020

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Chronic pruritus, defined as an unpleasant sensation resulting in a need to scratch that lasts more than 6 weeks, is a prevalent and bothersome symptom associated with both cutaneous and systemic conditions. Due to complex pathogenesis and profuse contributing factors, chronic pruritus therapy remains challenging. Regardless of the well-established antipruritic properties of classic pharmacotherapy (topical therapy, phototherapy and systemic therapy), these methods often provide insufficient relief for affected individuals. Owing to the growing interest in the field of pruritic research, further experimental and clinical data have emerged, continuously supporting the possibility of instigating novel therapeutic measures. This review covers the most relevant current modalities remaining under investigation that possess promising perspectives of approval in the near future, especially opioidergic drugs (mu-opioid antagonists and kappa-opioid agonists), neurokinin-1 receptor antagonists, biologic drugs, Janus kinase inhibitors, ileal bile acid transporter inhibitors, aryl hydrocarbon receptor agonists and histamine H 4 receptor antagonists.

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Section: Miscellaneous Modalitiesmentioning

confidence: 99%

Emerging Therapeutic Options for Chronic Pruritus

2020

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“…During the stimulation scan, participants experienced 20 trials of an acupuncture or tactile stimulus at four locations, and the order of stimulated locations was randomized in each participant (5 s for each stimulus with jittered intervals of 14:92 ± 1:66 s between trials). After the stimulus scan, another fMRI scan using the histamine-induced itch paradigm was acquired, and the results were reported elsewhere (see Min et al [25]). Anatomical images were acquired at the end of the session (Figure 1).…”

Section: Study Design and Experimentalmentioning

confidence: 99%

“…Tactile stimulation sites were located on the same meridian system but are not acknowledged as acupoints. Detailed information was described in our previous study [25].…”

Section: Somatosensory Stimulationmentioning

confidence: 99%

Spatial Information of Somatosensory Stimuli in the Brain: Multivariate Pattern Analysis of Functional Magnetic Resonance Imaging Data

et al. 2020

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Background. Multivoxel pattern analysis has provided new evidence on somatotopic representation in the human brain. However, the effects of stimulus modality (e.g., penetrating needle versus non-penetrating touch) and level of classification (e.g., multiclass versus binary classification) on patterns of brain activity encoding spatial information of body parts have not yet been studied. We hypothesized that performance of brain-based prediction models may vary across the types of stimuli, and neural patterns of voxels in the SI and parietal cortex would significantly contribute to the prediction of stimulated locations. Objective. We aimed to (1) test whether brain responses to tactile stimuli could distinguish among stimulated locations on the body surface, (2) investigate whether the stimulus modality and number of classes affect classification performance, and (3) localize brain regions encoding the spatial information of somatosensory stimuli. Methods. Fifteen healthy participants completed two functional magnetic resonance imaging (MRI) scans and were stimulated via the insertion of acupuncture needles or by non-invasive touch stimuli (5.46-sized von Frey filament). Participants received the stimuli at four different locations on the upper and lower limbs (two sites each) for 5 min while blood-oxygen-level-dependent activity (BOLD) was measured using 3-Tesla MRI. We performed multivariate pattern analysis (MVPA) using parameter estimate images of each trial for each participant and the support vector classifier (SVC) function, and the prediction accuracy and other MVPA outcomes were evaluated using stratified five-fold cross validation. We estimated the significance of the classification accuracy using a permutation test with randomly labeled training data (n=10,000). Searchlight analysis was conducted to identify brain regions associated with significantly higher accuracy compared to predictions based on chance as obtained from a random classifier. Results. For the four-class classification (classifying four stimulated points on the body), SVC analysis of whole-brain beta values in response to acupuncture stimulation was able to discriminate among stimulated locations (mean accuracy, 0.31; q<0.01). The searchlight analysis found that values related to the right primary somatosensory cortex (SI) and intraparietal sulcus were significantly more accurate than those due to chance (p<0.01). On the other hand, the same classifier did not predict stimulated locations accurately for touch stimulation (mean accuracy, 0.25; q=0.66). For binary classification (discriminating between two stimulated body parts, i.e., the arm or leg), the SVC algorithm successfully predicted the stimulated body parts for both acupuncture (mean accuracy, 0.63; q<0.001) and touch stimulation (mean accuracy, 0.60; q<0.01). Searchlight analysis revealed that predictions based on the right SI, primary motor cortex (MI), paracentral gyrus, and superior frontal gyrus were significantly more accurate compared to predictions based on chance (p<0.05). Conclusion. Our findings suggest that the SI, as well as the MI, intraparietal sulcus, paracentral gyrus, and superior frontal gyrus, is responsible for the somatotopic representation of body parts stimulated by tactile stimuli. The MVPA approach for identifying neural patterns encoding spatial information of somatosensory stimuli may be affected by the stimulus type (penetrating needle versus non-invasive touch) and the number of classes (classification of four small points on the body versus two large body parts). Future studies with larger samples will identify stimulus-specific neural patterns representing stimulated locations, independent of subjective tactile perception and emotional responses. Identification of distinct neural patterns of body surfaces will help in improving neural biomarkers for pain and other sensory percepts in the future.

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“…Besides, there are some other special objectives. All studies of complex mixed design combining the acupuncture events with active movements or passive stimulations are also conducted for complex purposes [42][43][44] .…”

Section: De Nitions and Conceptsmentioning

confidence: 99%

Acupuncture Mechanism Studies Employing Task-based fMRI: A Scoping Review Protocol

Yan¹,

Sheng²,

Wang³

et al. 2020

Preprint

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Background: Acupuncture is a widely used alternative and complementary therapy. Functional Magnetic Resonance Imaging (fMRI) is an important technique to explore the underlying mechanism of acupuncture, and the task-based fMRI can reflect the instant effects or sustained effects of acupuncture in the brain. This scoping review aims to summarize the characteristics of acupuncture mechanism studies employing Task-based fMRI and conclude a reference for future studies.Methods/design: This review will follow the Guidance for Conducting Systematic Scoping Reviews. Eligible articles will be collected from 6 databases (PubMed, Embase, Cochrane, CNKI, WanFang and VIP) with the related keywords such as “Acupuncture” and “fMRI” and those articles should be published from the establishment of the database to June 30th, 2020. Each research step will involve at least two reviewers. The PRISMA-ScR (Preferred Reporting Items for Systemic Reviews and Meta-Analysis Extension for Scoping Reviews) will be used to organize the review.Discussion: This review aims to clarify the extent of acupuncture mechanism studies employing task-based fMRI. It is supposed to make a critical evaluation or to propose quality requirements for future studies by summarizing the objectives and designs of eligible studies. What’s more, directional suggestions will be provided for further studies.Scoping review registration: Open Science Framework https://osf.io/zjrdc/.

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Acupuncture for Histamine-Induced Itch: Association With Increased Parasympathetic Tone and Connectivity of Putamen-Midcingulate Cortex

Cited by 24 publications

References 97 publications

Emerging Therapeutic Options for Chronic Pruritus

Emerging Therapeutic Options for Chronic Pruritus

Spatial Information of Somatosensory Stimuli in the Brain: Multivariate Pattern Analysis of Functional Magnetic Resonance Imaging Data

Acupuncture Mechanism Studies Employing Task-based fMRI: A Scoping Review Protocol

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