Asthma is a clinical syndrome that typically consists of increased airway hyper-responsiveness and recurrent episodes of airway obstruction and inflammation. Allergy is a heightened sensitivity to a foreign substance. The early interventions with anti-inflammatory agents have indicated that the inhalation of corticosteroids may be effective in the treatment of recurrent wheezing. Currently, long-term asthma control medicines have been prescribed to be taken by mouth in order to open the airways and prevent airway inflammation. Examples included inhaled long-acting B2-agonists (used with low-dose inhaled corticosteroids), leukotriene modifiers, cromolyn and nedocromil and theophylline. In future, the bronchial thermoplasty may become the first non-pharmaceutical treatment for asthma. Furthermore, there is an urgent need for new anti-asthma drugs, where there are millions of people suffering of severe asthma. New treatments have been attempted especially those involving plant and herbal extracts. Asthma and allergy updated knowledge have been highlighted in this review.