Acupuncture for Chemoradiation Therapy-Related Dysphagia in Head and Neck Cancer: A Pilot Randomized Sham-Controlled Trial

Lu, Weidong; Wayne, Peter M.; Davis, Roger B.; Buring, Julie E.; Li, Hailun; Macklin, Eric A.; Lorch, Jochen H.; Burke, Elaine; Haddad, Tyler; Goguen, Laura A.; Rosenthal, David S.; Tishler, Roy B.; Posner, Marshall R.; Haddad, Robert I.

doi:10.1634/theoncologist.2015-0538

Cited by 21 publications

(28 citation statements)

References 30 publications

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“…Of 7 PEG tube-dependent patients, 6 had their feeding tube removed after acupuncture. Building on these observations, a pilot randomized sham-controlled trial has been conducted, showing that both active acupuncture and sham acupuncture during and after head and neck RT are feasible and safe [128,132]. An improvement in the dysphagia-related QOL from the baseline to 12 months post-RT was observed in both treatment arms, though with no difference between the two.…”

Section: Dysphagiamentioning

confidence: 99%

Treatment of late sequelae after radiotherapy for head and neck cancer

Strojan

Hutcheson

Eisbruch

et al. 2017

Cancer Treatment Reviews

226

159

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Radiotherapy (RT) is used to treat approximately 80% of patients with cancer of the head and neck. Despite enormous advances in RT planning and delivery, a significant number of patients will experience radiation-associated toxicities, especially those treated with concurrent systemic agents. Many effective management options are available for acute RT-associated toxicities, but treatment options are much more limited and of variable benefit among patients who develop late sequelae after RT. The adverse impact of developing late tissue damage in irradiated patients may range from bothersome symptoms that negatively affect their quality of life to severe life-threatening complications. In the region of the head and neck, among the most problematic late effects are impaired function of the salivary glands and swallowing apparatus. Other tissues and structures in the region may be at risk, depending mainly on the location of the irradiated tumor relative to the mandible and hearing apparatus. Here, we review the available evidence on the use of different therapeutic strategies to alleviate common late sequelae of RT in head and neck cancer patients, with a focus on the critical assessment of the treatment options for xerostomia, dysphagia, mandibular osteoradionecrosis, trismus, and hearing loss.

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Section: Dysphagiamentioning

confidence: 99%

Treatment of late sequelae after radiotherapy for head and neck cancer

Strojan

Hutcheson

Eisbruch

et al. 2017

Cancer Treatment Reviews

226

159

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“…A RCT enrolled 42 patients who had stage III-IV squamous cell carcinoma with dysphagia after CRT and randomized them either to active acupuncture or sham acupuncture. 37 Swallowing-related QoL was assessed using the MD Anderson Dysphagia Inventory (MDADI) total and subscale scores. Significant improvement was found in both groups from baseline to 12 months post-CRT for MDADI total scores (AA: +7.9; SA +13.9; P = .044, P < .001) and MDADI global subscale scores (AA: +25.0; SA +22.7; P = .001, P = .002).…”

Section: Acupuncture For Patients With Head and Neck Cancermentioning

confidence: 99%

“…Chemoradiation therapy (CRT) related dysphagia has also been studied using acupuncture. A RCT enrolled 42 patients who had stage III–IV squamous cell carcinoma with dysphagia after CRT and randomized them either to active acupuncture or sham acupuncture . Swallowing‐related QoL was assessed using the MD Anderson Dysphagia Inventory (MDADI) total and subscale scores.…”

Section: Introductionmentioning

confidence: 99%

Integrative care of the patient with head and neck cancer

Nguyen

Taw²,

Wang³

2018

Laryngoscope Investig Oto

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ObjectiveTo review the literature on integrative care of the patient with head and neck cancer.MethodsA review of the English language literature for articles relating to integrative care of patients with head and neck cancer, focusing on treatment of sequelae of surgery and chemoradiation.ResultsMany studies show a significant utilization of nontraditional (complementary/integrative) treatments by patients in dealing with head and neck cancer. Treatment of head and neck cancer entails potentially debilitating consequences of surgery and/or chemoradiation on cosmesis, speech, swallowing, breathing, and quality of life. While complementary/integrative treatments for head and neck cancer are not established as effective therapies, their use for relieving sequelae of treatment, improving quality of life, and providing potential chemoprevention is well documented.ConclusionGiven the landscape of increasing use of nontraditional methodologies by patients with head and neck cancer and the complexity of care, the head and neck cancer surgeon should be aware of the uses and abuses of complementary/integrative medicine by patients as they navigate their care.Level of Evidence5

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“…Acupuncture can improve patients’ tolerance of therapy as well as shorten the recovery period. Previous clinical studies showed the effect of acupuncture in other radiotherapy-related adverse effects such as xerostomia [ 13 ] or dysphagia [ 14 ]. This study was driven by the motivation to verify that assumption on a cohort of our own patients.…”

Section: Discussionmentioning

confidence: 99%

Effect of Acupuncture in Pain Management of Head and Neck Cancer Radiotherapy: Prospective Randomized Unicentric Study

Dymáčková

Selingerová

Kazda

et al. 2021

JCM

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This prospective randomized open-label trial aimed to evaluate the role of acupuncture in the treatment of pain related to curative and adjuvant (chemo)radiotherapy of head and neck cancer. Patients in two arms (30 patients in each arm) underwent standard oncology therapy and standard supportive care with or without acupuncture. The stratification factors were the type of treatment and chemotherapy indication. The toxicity assessed was represented by pain rated on a 10-point pain scale and analgesic use. Average pain (AP) and the worst pain during the day (WP) were significantly lower in the acupuncture arm during radiotherapy (AP median 0.16 vs. 1.36, p < 0.001; WP median 0.90 vs. 1.96, p < 0.001) and three months after radiotherapy (AP median 0.07 vs. 0.50, p < 0.001; WP median 0.30 vs. 0.83, p = 0.002). The analgesic consumption between arms was statistically significantly different. A median of the proportion of days when the patients used analgesics was 8% and 32.5% during radiotherapy (p = 0.047) and 0% and 20.8% during three months after radiotherapy (p = 0.006) for the acupuncture and control arm, respectively. Results point out lower analgesic consumption and milder pain in acupuncture arm. Acupuncture consequently offers another alternative to standard treatment leading to a reduction in the toxicity of oncological treatment.

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Acupuncture for Chemoradiation Therapy-Related Dysphagia in Head and Neck Cancer: A Pilot Randomized Sham-Controlled Trial

Cited by 21 publications

References 30 publications

Treatment of late sequelae after radiotherapy for head and neck cancer

Treatment of late sequelae after radiotherapy for head and neck cancer

Integrative care of the patient with head and neck cancer

Effect of Acupuncture in Pain Management of Head and Neck Cancer Radiotherapy: Prospective Randomized Unicentric Study

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