Acupuncture Enhances Signals at Sensitized Acupoints to Elevate Pressure Pain Threshold in Knee Osteoarthritis Patients

Wang, Xiaoyu; Nie, Zhong-yi; Yu, Qi; Chen, Wei; ZHANG, Xiao-ning; Wan, Heng; Su, Yang-Shuai; He, Wei; Li, Ru-ya; Jing, Xiang-Hong

doi:10.1007/s11655-022-3588-6

Cited by 7 publications

(3 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These points in TCM theory are interpreted as tonifying Qi and Blood, promoting the circulation of meridian channels and collaterals, leading to facilitating joint function recovery. Previous RCTs have also con rmed that acupoint stimulation around the knee joint has a signi cant effect on KOA and improves patients' pressure-pain threshold [53,55], which was consistent with the ndings of our previous study [39]. This multicenter pilot study expands patient recruitment beyond a single hospital setting to minimize regional differences that may exist.…”

Section: Discussionsupporting

confidence: 88%

Tuina on knee pain and physical function for patients with mild-moderate knee osteoarthritis in Shanghai: protocol for a multicenter, assessor-blinded, randomized controlled trial

Ma,

Guo,

Yue

et al. 2023

Preprint

View full text Add to dashboard Cite

Background Knee osteoarthritis (KOA) is one of the most common osteoarthritis, imposing substantial economic and medical burdens on both individuals and society. In China, Tuina has been chosen as a complementary and alternative therapy to relieve symptoms of knee pain and dysfunction. However, current evidence is insufficient to support the efficacy of Tuina therapy in addressing knee pain and improving physical function. The purpose of this trial was to investigate the efficacy of Tuina compared to celecoxib, by observing changes in outcome measures and assessing its level of effectiveness as an alternative treatment. Methods and analysis A total of 360 patients with KOA aged between 40 and 70 years and classified as Kellgren and Lawrence Grade I-II will be recruited from eight sub-central hospitals. The participants will be randomly assigned to either the treatment group (Tuina, Biw) or the control group (Celecoxib, Qd), with both groups undergoing a 4-week intervention phase followed by an 8-week follow-up phase. The primary outcome is the change of Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscale at week 4 compared with baseline. Secondary outcomes including WOMAC stiffness and function subscales, WOMAC total score, 36-item short form health survey (SF-36), timed up and go test (TUG), short physical performance battery (SPPB), gait analysis parameters, and pain medication records will be assessed at weeks 4, 8, and 12. Any adverse events occurring during the trial will be promptly recorded. Discussion This multicenter randomized trial aims to evaluate the effectiveness of Tuina on relieving pain and increasing physical function of KOA patients. This protocol, if proven effective, will present more compelling evidence supporting the value of Tuina and contribute to providing a promising alternative therapy for patients with mild-moderate KOA. Trial registration number: This trial has been registered in the China Clinical Trials Registry (registration number: ChiCTR2300069416).

show abstract

Section: Discussionsupporting

confidence: 88%

Tuina on knee pain and physical function for patients with mild-moderate knee osteoarthritis in Shanghai: protocol for a multicenter, assessor-blinded, randomized controlled trial

Ma,

Guo,

Yue

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…PPT is also used to measure acupoint sensitization; traditional Chinese medicine believes that the state of acupoints is dynamic and PPT of acupoints changes with the disease. For instance, some studies indicated that lower PPT was observed at the sensitized acupoints in the patients with disease [ 52 , 53 ], and the underlying mechanism of the acupoint sensitization may be related to the high expression of local allergic substances and nociceptive neuropeptides in the local skin [ 54 ]. However, in our study, group A had higher PPT compared with group B in some acupoints.…”

Section: Discussionmentioning

confidence: 99%

“…Compared with group B, the group A had signifcantly higher SAS scores (median 49 (IQR, [45][46][47][48][49][50][51][52][53][54] 3).…”

Section: Te Emotion and Pain Scores In The Two Groupsmentioning

confidence: 92%

The Impact and Correlation of Anxiety and Depression on Pressure Pain Threshold of Acupoints in Patients with Chronic Pelvic Inflammatory Disease

Liao,

Tan,

Wang

et al. 2023

Pain Research and Management

View full text Add to dashboard Cite

Background. Chronic pelvic inflammatory disease (CPID) is a clinically common gynecological disease. Patients experience chronic pelvic pain and often accompany with emotional dysfunction. However, the impact and correlation of anxiety and depression on pain sensitization is not completely known. Objective. To explore the differences and correlations among anxiety, depression, and pressure pain threshold (PPT) of acupoints in patients with CPID. Methods. One hundred and forty-seven patients with CPID were recruited. The Visual Analog Scale (VAS) and short-form McGill Pain Questionnaire (SF-MPQ) were used to assess pain. Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) were used to evaluate the emotional state of patients. The PPT of acupoints was collected using an electronic Von Frey by two licensed acupuncturists. Results. The CPID patients were divided into anxiety-depression group (group A) or nonanxiety-depression group (group B), according to the SAS and SDS scores. Finally, there were 73 patients in group A and 74 patients in group B. Group A had significantly higher SAS, SDS, VAS, and SF-MPQ scores than group B ( P < 0.05 ). In addition, significant differences were observed in the PPTs of ST28 (R), ST29 (R), SP10 (R), SP9 (R), SP9 (L), ST36 (R), and LR3 (L) between the two groups ( P < 0.05 ). No considerable differences in PPTs at the other acupoints were observed between the two groups. SAS scores showed a positive correlation with PPTs of ST29 (R), SP10 (R), SP9 (L), ST36 (R), and LR3 (L). No remarkable correlation was observed between the SDS scores and PPTs. Conclusion. Anxiety and depression can affect the PPT of some acupoints in CPID patients, which may provide a reference for acupoint selection for acupuncture treatment of CPID with emotional disorders. This trial is registered with ChiCTR2100052632.

show abstract

Paeoniflorin, the Main Monomer Component of Paeonia lactiflora, Exhibits Anti-inflammatory Properties in Osteoarthritis Synovial Inflammation

Chen,

Zhou,

Ruan

et al. 2023

Chin. J. Integr. Med.

View full text Add to dashboard Cite

Acupuncture Enhances Signals at Sensitized Acupoints to Elevate Pressure Pain Threshold in Knee Osteoarthritis Patients

Cited by 7 publications

References 24 publications

Tuina on knee pain and physical function for patients with mild-moderate knee osteoarthritis in Shanghai: protocol for a multicenter, assessor-blinded, randomized controlled trial

Tuina on knee pain and physical function for patients with mild-moderate knee osteoarthritis in Shanghai: protocol for a multicenter, assessor-blinded, randomized controlled trial

The Impact and Correlation of Anxiety and Depression on Pressure Pain Threshold of Acupoints in Patients with Chronic Pelvic Inflammatory Disease

Paeoniflorin, the Main Monomer Component of Paeonia lactiflora, Exhibits Anti-inflammatory Properties in Osteoarthritis Synovial Inflammation

Contact Info

Product

Resources

About