Acupuncture enhances cell proliferation in dentate gyrus of maternally-separated rats

Park, Hi-Joon; Lim, Sabina; Lee, Hyang-Sook; Lee, Hyejung; Yoo, Yeong‐Min; Lee, Hee Jae; Kim, Soon Ae; Yin, Chang-Shik; Jung-Chul, Seo; Chung, Joo‐Ho

doi:10.1016/s0304-3940(01)02581-2

Cited by 29 publications

(13 citation statements)

References 20 publications

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“…Previous studies (Greisen et al, 2005;Mirescu et al, 2004) have reported conflicting results on the regulation of hippocampal neurogenesis in adulthood in MS animals. Although our results are in agreement with a previous report showing no change in adult neurogenesis following MS (Greisen et al, 2005), they differ from other studies that report a decline in hippocampal progenitor proliferation in adulthood (Mirescu et al, 2004;Park et al, 2002). It is possible that the discrepancy in these findings arise from differences in the BrdU dosing regimens and in the MS paradigms.…”

Section: Stress Regulation Of Bdnf and Creb Transcriptssupporting

confidence: 71%

Stressor-Specific Regulation of Distinct Brain-Derived Neurotrophic Factor Transcripts and Cyclic AMP Response Element-Binding Protein Expression in the Postnatal and Adult Rat Hippocampus

Nair

Vadodaria

Banerjee

et al. 2006

Neuropsychopharmacol

171

120

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Stress regulation of brain-derived neurotrophic factor (BDNF) is implicated in the hippocampal damage observed in depression. BDNF has a complex gene structure with four 5 0 untranslated exons (I-IV) with unique promoters, and a common 3 0 coding exon (V). To better understand the stress regulation of BDNF, we addressed whether distinct stressors differentially regulate exon-specific BDNF transcripts in the postnatal and adult hippocampus. The early life stress of maternal separation (MS) resulted in a time point-dependent differential upregulation of BDNF transcripts restricted to early postnatal life (P14-BDNF II, P21-BDNF IV, V). In adulthood, distinct stressors regulated BDNF transcripts in a signature manner. Immobilization stress, administered once, decreased all BDNF splice variants but had differing effects on BDNF I/II (increase) and III/IV (decrease) when administered chronically. Although immobilization stress reduced BDNF (V) mRNA, chronic unpredictable stress did not influence total BDNF despite altering specific BDNF transcripts. Furthermore, a prior history of MS altered the signature pattern in which adult-onset stress regulated specific BDNF transcripts. We also examined the expression of cyclic AMP response element-binding protein (CREB), an upstream transcriptional activator of BDNF, and observed a CREB induction in the postnatal hippocampus following MS. As a possible consequence of enhanced CREB and BDNF expression following MS, we examined hippocampal progenitor proliferation and observed a significant increase restricted to early life. These results suggest that alterations in CREB/BDNF may contribute to the generation of individual differences in stress neurocircuitry, providing a substrate for altered vulnerability to depressive disorders.

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Section: Stress Regulation Of Bdnf and Creb Transcriptssupporting

confidence: 71%

Stressor-Specific Regulation of Distinct Brain-Derived Neurotrophic Factor Transcripts and Cyclic AMP Response Element-Binding Protein Expression in the Postnatal and Adult Rat Hippocampus

Nair

Vadodaria

Banerjee

et al. 2006

Neuropsychopharmacol

171

120

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“…On postnatal day (pnd) 14 (Lim et al 2003;Park et al 2002), pups were randomly assigned to one of four groups (n = 8 per group): control, acupuncture, MS, and acupuncture-treated MS groups. Pups of control and acupuncture groups were housed with their mothers under standard conditions; those of MS and acupuncture-treated MS groups were maintained individually for 7 days (pnd 14-21).…”

Section: Methodsmentioning

confidence: 99%

“…For the HT7 acupuncture stimulation (Lim et al 2003;Park et al 2002Park et al , 2005, stainless needles (0.2 mm diameter) were inserted about 3 mm into the left and right side at the selected acupuncture points. The needles were twisted twice a second for 30 s and then removed.…”

Section: Methodsmentioning

confidence: 99%

“…We previously reported the effects of acupuncture at acupoint HT7 (Shenmen), which has been used to treat mental disorders in Oriental medicine (Lin 1995), on early life stress using the MS animal models. In our previous study, acupuncture at HT7 reduced anxiety-related behaviors, enhanced neuropeptide Y expression in the amygdala and hippocampus, and increased cell proliferation in the dentate gyrus of MS rats (Lim et al 2003;Park et al 2002Park et al , 2005. In this study, we further investigated the ability of acupuncture at acupoint HT7 on early life stress by analyzing anxiety-related behaviors, and the activation of the HPA system using the MS animal model.…”

Section: Introductionmentioning

confidence: 94%

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Effect of Acupuncture on Hypothalamic–Pituitary–Adrenal System in Maternal Separation Rats

et al. 2011

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The maternal separation (MS) animal model has been widely used to study early life stress and several psychiatric conditions such as depression and anxiety. In this study, we investigated the effect of acupuncture on anxiety-related behaviors and hypothalamic-pituitary-adrenal (HPA) system in MS-induced early life stress of Sprague-Dawley rat pups (14-21 postnatal days). For determining anxiety-related behaviors, the elevated plus-maze test was performed. The effects of acupuncture on the activation of stress were measured by assessing plasma levels of corticosterone (CORT) and adrenocorticotropin hormone (ACTH). The hypothalamic immunoreactivity (IR) of arginine vasopressin (AVP) was also examined. Acupuncture was conducted at acupoint HT7, which is used to treat mental disorders in Oriental medicine, for seven consecutive days. Acupuncture significantly decreased the frequencies of open arm entries and the amount of time spent in the open arms in MS rats. In addition, acupuncture reduced CORT and ACTH levels in plasma of MS rats, and AVP-IR in the hypothalamic paraventricular nucleus of MS rats. In conclusion, acupuncture reduced anxiety-related behaviors and modulated the HPA system. These findings suggest that acupuncture at HT7 may be useful as a therapeutic treatment in MS-induced early life stress.

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“…For example, in rats as well as in mice it was shown that a single episode of prolonged (24 h) separation stress decreases neurogenesis and reduces cell survival in the dentate gyrus [60,64]. Similarly, repeated mild maternal separation in rats was reported to induce a transient and/or permanent increase and/or decrease in neurogenesis in the dentate gyrus, depending on the respective developmental stages [65,66,67,68,69]. Decreased, adult hippocampal cell proliferation was associated with impaired cognitive performance, but it had little correlation with stress sensitivity and anxiety in adult rats [70].…”

Section: Attachment and Separation Stress Induce Changes In Metabolicmentioning

confidence: 99%

The Impact of Parent-Infant Interaction on Epigenetic Plasticity Mediating Synaptic Adaptations in the Infant Brain

Matas

Bock²,

Braun³

2016

Psychopathology

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The development of the brain depends on an individual's nature (genes) and nurture (environments). This interaction between genetic predispositions and environmental events during brain development drives the maturation of functional brain circuits such as sensory, motor, emotional, and complex cognitive pathways. Adverse environmental conditions such as early life stress can interfere with the functional development of emotional and cognitive brain systems and thereby increase the risk of developing psychiatric disorders later in life. In order to develop more efficient and individualized protective and therapeutic interventions, it is essential to understand how environmental stressors during infancy affect cellular and molecular mechanisms involved in brain maturation. Animal models of early life stress have been able to reveal brain structural and metabolic changes in prefrontolimbic circuits, which are time, brain region, neuron, and sex specific. By focusing on animal models of separation stress during infancy, this review highlights epigenetic and cytoarchitectural modifications which are assumed to mediate lasting changes of brain function and behavior.

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Acupuncture enhances cell proliferation in dentate gyrus of maternally-separated rats

Cited by 29 publications

References 20 publications

Stressor-Specific Regulation of Distinct Brain-Derived Neurotrophic Factor Transcripts and Cyclic AMP Response Element-Binding Protein Expression in the Postnatal and Adult Rat Hippocampus

Stressor-Specific Regulation of Distinct Brain-Derived Neurotrophic Factor Transcripts and Cyclic AMP Response Element-Binding Protein Expression in the Postnatal and Adult Rat Hippocampus

Effect of Acupuncture on Hypothalamic–Pituitary–Adrenal System in Maternal Separation Rats

The Impact of Parent-Infant Interaction on Epigenetic Plasticity Mediating Synaptic Adaptations in the Infant Brain

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