Acupuncture accelerates neural regeneration and synaptophysin production after neural stem cells transplantation in mice

Zhao, Lan; Liu, Jianwei; Kan, Bohong; Shi, Huiyan; Yang, Lin-Po; Liu, Xinyu

doi:10.4252/wjsc.v12.i12.1576

Cited by 16 publications

(13 citation statements)

References 54 publications

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“…Various hypotheses have been proposed to illustrate the acupuncture mechanism on NSCs. First, acupuncture could promote nerve regeneration and synaptogenesis by regulating the microenvironment of NSC transplantation and promoting SCI recovery ( Tang et al, 2020c ; Zhao et al, 2020 ; Yang et al, 2021 ). Second, electroacupuncture promotes the proliferation and differentiation of endogenous NSCs by regulating numerous endogenous signals.…”

Section: Mechanism Of Acupuncture Therapy In Spinal Cord Injurymentioning

confidence: 99%

Mechanism Underlying Acupuncture Therapy in Spinal Cord Injury: A Narrative Overview of Preclinical Studies

Jiang¹,

Sun²,

Chen³

2022

Front. Pharmacol.

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Spinal cord injury (SCI) results from various pathogenic factors that destroy the normal structure and function of the spinal cord, subsequently causing sensory, motor, and autonomic nerve dysfunction. SCI is one of the most common causes of disability and death globally. It leads to severe physical and mental injury to patients and causes a substantial economic burden on families and the society. The pathological changes and underlying mechanisms within SCI involve oxidative stress, apoptosis, inflammation, etc. As a traditional therapy, acupuncture has a positive effect promoting the recovery of SCI. Acupuncture-induced neuroprotection includes several mechanisms such as reducing oxidative stress, inhibiting the inflammatory response and neuronal apoptosis, alleviating glial scar formation, promoting neural stem cell differentiation, and improving microcirculation within the injured area. Therefore, the recent studies exploring the mechanism of acupuncture therapy in SCI will help provide a theoretical basis for applying acupuncture and seeking a better treatment target and acupuncture approach for SCI patients.

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Section: Mechanism Of Acupuncture Therapy In Spinal Cord Injurymentioning

confidence: 99%

Mechanism Underlying Acupuncture Therapy in Spinal Cord Injury: A Narrative Overview of Preclinical Studies

Jiang¹,

Sun²,

Chen³

2022

Front. Pharmacol.

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“…Studies on the effects of EA and nonacupoint on cognitive impairment are limited. Clinical and basic studies have mostly set up nonacupoint groups to confirm the specificity of EA therapy [39][40][41].…”

Section: Discussionmentioning

confidence: 99%

Electroacupuncture Increases the Hippocampal Synaptic Transmission Efficiency and Long-Term Plasticity to Improve Vascular Cognitive Impairment

Dai

Zhang

Yang

et al. 2022

Mediators of Inflammation

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Studies have shown that electroacupuncture (EA) can effectively improve vascular cognitive impairment (VCI), but its mechanisms have not been clearly elucidated. This study is aimed at investigating the mechanisms underlying the effects of EA treatment on hippocampal synaptic transmission efficiency and plasticity in rats with VCI. Methods. Sprague–Dawley rats were subjected to VCI with bilateral common carotid occlusion (2VO). EA stimulation was applied to Baihui (GV20) and Shenting (GV24) acupoints for 30 min once a day, five times a week, for four weeks. Our study also included nonacupoint groups to confirm the specificity of EA therapy. The Morris water maze (MWM) was used to assess cognitive function. Electrophysiological techniques were used to detect the field characteristics of the hippocampal CA3–CA1 circuit in each group of rats, including input-output (I/O), paired-pulse facilitation ratios (PPR), field excitatory postsynaptic potential (fEPSP), and excitatory postsynaptic current (EPSC). The expression of synapse- and calcium-mediated signal transduction associated proteins was detected through western blotting. Results. The MWM behavioural results showed that EA significantly improved cognitive function in VCI model rats. EA increased the I/O curve of VCI model rats from 20 to 90 μA. No significant differences were observed in hippocampal PPR. The fEPSP of the hippocampal CA3–CA1 circuit was significantly increased after EA treatment compared with that after nonacupuncture treatment. We found that EA led to an increase in the EPSC amplitude and frequency, especially in the decay and rise times. In addition, the protein expression and phosphorylation levels of N-methyl-D-aspartate receptor 2B, α-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor 1, and Ca2+-calmodulin-dependent protein kinase II increased to varying degrees in the hippocampus of VCI model rats. Conclusion. EA at GV20 and GV24 acupoints increased the basic synaptic transmission efficiency and synaptic plasticity of the hippocampal CA3–CA1 circuit, thereby improving learning and memory ability in rats with VCI.

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“…As a sign of synaptogenesis [35], reduction of synaptic proteins in neurons of the cerebral cortex can lead to cognitive dysfunction. Zhao et al stimulated "Danzhong" (CV17), "Zhongwan" (CV12), "Qihai" (CV6), bilateral "Xuehai" (SP10), and "Zusanli" (ST36) by sanjiao acupuncture and found that sanjiao acupuncture increased SYN expression, promoted neural regeneration and synaptogenesis, repaired damaged neurons, and improved memory impairment in SAMP8 mice [36]. PSD-95 is the most abundant scaffold protein in the synaptic dense part, modulating the postsynaptic response to glutamate release by regulating the anchoring of glutamate receptors.…”

Section: Potential Mechanisms Underlying Thementioning

confidence: 99%

“…2-VO rats MA "Baihui" (GV20), "Zusanli" (ST36) [94] Row twist compensation method (<90 °, >120 times/min, 30 s), once a day, 6 days of treatment, 1 day of rest, a total treatment of 12 times SAMP8 mice MA "Danzhong" (CV17), "Zhongwan" (CV12), "Qihai" (CV6) [36] Twisting reinforcing manipulation method, 1 time/d, 15 d, and suspended only on day 7 APP/PS1 mice EA "Baihui" (GV20), "Yongquan" (KI1) [41] 2 ~3 mm, "Baihui": Flat stab, "Yongquan": Straight stab, density wave, 1 Hz/50 Hz, 0.5 mA, 15 min/d, 3 times/week, 6 weeks SAMP8 mice EA "Baihui" (GV20), "Zusanli" (ST36) [64] 3 mm, 1 mA, 10 Hz, 30 min/d, 14 days D-galactose-treated rats EA "Baihui" (GV20), "Shenshu" (BL23) [65] "Baihui": Inserted 15 °obliquely, 2 mm. "Shenshu": Inserted perpendicularly, 4-6 mm.…”

Section: -Vo Rats Eamentioning

confidence: 99%

Acupuncture Interventions for Alzheimer’s Disease and Vascular Cognitive Disorders: A Review of Mechanisms

Yang

Wang

et al. 2022

Oxidative Medicine and Cellular Longevity

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Cognitive impairment (CI) related to Alzheimer’s disease (AD) and vascular cognitive disorders (VCDs) has become a key problem worldwide. Importantly, CI is a neuropsychiatric abnormality mainly characterized by learning and memory impairments. The hippocampus is an important brain region controlling learning and memory. Recent studies have highlighted the effects of acupuncture on memory deficits in AD and VCDs. By reviewing the literature published on this topic in the past five years, the present study intends to summarize the effects of acupuncture on memory impairment in AD and VCDs. Focusing on hippocampal synaptic plasticity, we reviewed the mechanisms underlying the effects of acupuncture on memory impairments through regulation of synaptic proteins, AD characteristic proteins, intestinal microbiota, neuroinflammation, microRNA expression, orexin system, energy metabolism, etc., suggesting that hippocampal synaptic plasticity may be the common as well as the core link underlying the above mechanisms. We also discussed the potential strategies to improve the effect of acupuncture. Additionally, the effects of acupuncture on synaptic plasticity through the regulation of vascular–glia–neuron unit were further discussed.

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Acupuncture accelerates neural regeneration and synaptophysin production after neural stem cells transplantation in mice

Cited by 16 publications

References 54 publications

Mechanism Underlying Acupuncture Therapy in Spinal Cord Injury: A Narrative Overview of Preclinical Studies

Mechanism Underlying Acupuncture Therapy in Spinal Cord Injury: A Narrative Overview of Preclinical Studies

Electroacupuncture Increases the Hippocampal Synaptic Transmission Efficiency and Long-Term Plasticity to Improve Vascular Cognitive Impairment

Acupuncture Interventions for Alzheimer’s Disease and Vascular Cognitive Disorders: A Review of Mechanisms

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