Actualización en la patología pulmonar relacionada con la infección VIH

Estébanez-Muñoz, Miriam; Soto-Abánades, Clara I.; Ríos-Blanco, Juan José; Arribas, José Ramón

doi:10.1016/j.arbres.2011.12.001

Cited by 4 publications

(2 citation statements)

References 80 publications

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“…Although the pathogenic mechanisms of HIV-associated COPD remains unclear [5], it may be due in part to higher prevalence of smoking in these individuals [6]. Other risk behaviors, such as use of injected and inhalational drugs, also damage the lungs [7].…”

Section: Introductionmentioning

confidence: 99%

Trends in Epidemiology of COPD in HIV-Infected Patients in Spain (1997–2012)

et al. 2016

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PurposeThe aim of this study was to estimate trends of incidence of hospital admissions and in-hospital mortality (IHM) in HIV-infected patients with COPD in the combination antiretroviral therapy (cART) era in Spain (1997–2012).MethodsA retrospective study with data from nationwide population-based COPD diagnoses in the Spanish Minimum Basic Data Set (MBDS) was performed. We established groups according to their HIV and HCV infections: 1) HIV-uninfected patients; 2) HIV-infected patients (with or without HCV coinfection).Results1,580,207 patients discharge with a COPD diagnosis were included in the study, 8902 of them were HIV-infected patients (5000 HIV-monoinfected patients and 3902 HIV/HCV-coinfected patients). The HIV-infected patients had higher incidence rates of hospital admissions for COPD than the HIV-uninfected patients during the study period. The HIV-monoinfected patients had higher rates of hospitalizations for COPD than the HIV/HCV-coinfected patients in the early-period cART (1997–1999), but these rates decreased in the first group and increased in the second, being even similar in both groups in the late-period cART (2004–2011). On the other hand, the HIV-infected patients with COPD had higher IHM than the HIV-uninfected patients with COPD. The mortality rates were higher in the HIV-monoinfected patients with COPD than in the HIV/HCV-coinfected patients with COPD in the early-period cART; however, in the late-period cART, the mortality rates trends seems higher in the HIV/HCV group. The likelihood of death in HIV/HCV-coinfected patients with COPD was similar to than in HIV-monoinfected patients with COPD.ConclusionsIncidence of hospital admissions for COPD and IHM have decreased among HIV-monoinfected individuals but have increased steadily among HIV/HCV-coinfected individuals in the cART era.

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Section: Introductionmentioning

confidence: 99%

Trends in Epidemiology of COPD in HIV-Infected Patients in Spain (1997–2012)

et al. 2016

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“…However, the mortality rates in the developing world and certain urban areas of the United States underserved by the health care establishment approach 80% (4). Recent evidence correlating P. jirovecii as a comorbidity agent in respiratory conditions like chronic obstructive pulmonary disease (COPD) (5) or pneumonia in association with anti-tumor necrosis factor (TNF) antibody therapies (6) or with lung cancers (7) indicates a broadening of the population susceptible to PCP. In addition, patients with chronic inflammatory conditions are also showing increased infections due to concomitant corticosteroid therapy and other immunomodulators (8).…”

Section: Introductionmentioning

confidence: 99%

Functional Characterization of Pneumocystis carinii Inositol Transporter 1

Cushion

Collins

Sesterhenn

et al. 2016

mBio

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Fungi in the genus Pneumocystis live in the lungs of mammals, where they can cause a fatal pneumonia (PCP [Pneumocystis pneumonia]) in hosts with compromised immune systems. The absence of a continuous in vitro culture system for any species of Pneumocystis has led to limited understanding of these fungi, especially for the discovery of new therapies. We recently reported that Pneumocystis carinii, Pneumocystis murina, and most significantly, Pneumocystis jirovecii lack both enzymes necessary for myo-inositol biosynthesis but contain genes with homologies to fungal myo-inositol transporters. Since myo-inositol is essential for eukaryotic viability, the primary transporter, ITR1, was functionally and structurally characterized in P. carinii. The predicted structure of P. carinii ITR1 (PcITR1) contained 12 transmembrane alpha-helices with intracellular C and N termini, consistent with other inositol transporters. The apparent Km was 0.94 ± 0.08 (mean ± standard deviation), suggesting that myo-inositol transport in P. carinii is likely through a low-affinity, highly selective transport system, as no other sugars or inositol stereoisomers were significant competitive inhibitors. Glucose transport was shown to use a different transport system. The myo-inositol transport was distinct from mammalian transporters, as it was not sodium dependent and was cytochalasin B resistant. Inositol transport in these fungi offers an attractive new drug target because of the reliance of the fungi on its transport, clear differences between the mammalian and fungal transporters, and the ability of the host to both synthesize and transport this critical nutrient, predicting low toxicity of potential inhibitors to the fungal transporter.

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Hipertensión arterial pulmonar asociada a virus de la inmunodeficiencia humana. El tópico olvidado

Sandoval-Gutiérrez¹

2014

Archivos de Cardiología de México

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Actualización en la patología pulmonar relacionada con la infección VIH

Cited by 4 publications

References 80 publications

Trends in Epidemiology of COPD in HIV-Infected Patients in Spain (1997–2012)

Trends in Epidemiology of COPD in HIV-Infected Patients in Spain (1997–2012)

Functional Characterization of Pneumocystis carinii Inositol Transporter 1

Hipertensión arterial pulmonar asociada a virus de la inmunodeficiencia humana. El tópico olvidado

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