Actualización (2003) de las Guías de Práctica Clínica de la Sociedad Española de Cardiología en hipertensión arterial

González-Juanatey, José Ramón; Ramos, Pilar Mazón; Arcos, Federico Soria; Alonso, Vivencio Barrios; Padial, Luis Rodrı́guez; Martínez, Vicente Bertoméu

doi:10.1157/13047014

Cited by 62 publications

(6 citation statements)

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“…Strokes were classified based on the affected vascular territory in carotid extracranial, anterior intracranial, and vertebrobasilar systems. The vascular risk factors data were obtained from the patient, families, caregivers, or prior medical records following the definitions recommended by the International guidelines 22,23 as follows: arterial hypertension (evidence of at least 2 raised blood pressure measurements, systolic Ͼ140 mm Hg or diastolic Ͼ90 mm Hg recorded on different days before stroke onset, a physician diagnosis, or use of medication), diabetes (a physician diagnosis or use of diabetes medication), hyperlipidemia (physician diagnosis, use of medication, serum cholesterol concentration Ͼ220 mg/dL, or serum triglyceride concentration Ͼ150 mg/dL), current smoking habit, ischemic heart disease (documented history of angina pectoris or myocardial infarction), peripheral arterial disease (physician diagnosis of intermittent claudication), atrial fibrillation (documented history or diagnosis during hospitalization), heart failure (documented history), previous stroke, and previous use of antithrombotic or statin treatments. Additional factors recorded were age, gender, and previous disability (modified Rankin scale Ͼ1).…”

Section: Methodsmentioning

confidence: 99%

Early Arterial Study in the Prediction of Mortality After Acute Ischemic Stroke

Ois

Cuadrado-Godia

Jiménez‐Conde

et al. 2007

Stroke

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Background and Purpose-The purpose of this study was to evaluate the value of the initial arterial study as a predictor of 90-day mortality in patients with acute ischemic stroke. Methods-A total of 1220 unselected patients assessed during the first 24 hours after stroke onset were prospectively studied. Initial stroke severity was evaluated by the National Institutes of Health Stroke Scale and dichotomized in mild (National Institutes of Health Stroke Scale Յ7) and severe (National Institutes of Health Stroke Scale Ͼ7). Severe arterial stenosis (Ն70%) or arterial occlusion in the symptomatic territory was determined by a Doppler study and also by additional explorations (carotid duplex, MR or CT angiography) in the first 24 hours after admission. The following variables were also analyzed: age, gender, previous functional status, smoking, hypertension, hyperlipidemia, diabetes mellitus, peripheral arterial disease, ischemic heart disease, heart failure, atrial fibrillation, previous stroke, and prior use of antithrombotic or statins. Ninety-day mortality was the end point of the study. Results-Ninety-day mortality was 15.7%. A total of 25.5% of all deaths were in patients with mild stroke. In addition to well-known factors related to mortality (age, stroke severity, ischemic heart disease, heart failure, and previous disability), severe arterial stenosis/occlusion was the factor with the highest relationship with 90-day mortality (adjusted OR: stenosis 2.13, occlusion 4.42, both 3.36). Arterial stenosis/occlusion was a higher predictor of 90-day mortality in patients with mild (adjusted OR: 5.38) than severe stroke (adjusted OR: 3.05). Conclusions-Severe arterial stenosis/occlusion in the early arterial study was highly related with 90-day mortality in an unselected series of patients with stroke. These data achieve special relevance in patients with initial mild stroke.

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Section: Methodsmentioning

confidence: 99%

Early Arterial Study in the Prediction of Mortality After Acute Ischemic Stroke

Ois

Cuadrado-Godia

Jiménez‐Conde

et al. 2007

Stroke

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“…The same values are recommended for patients with MS. 13 Angiotensin converting enzyme (ACE) inhibitors have demonstrated multiple beneficial effects on cardiovascular complications and for that reason are considered the first line, or preferred treatment for high blood pressure, particularly when established or incipient kidney disease is present. 35,36 Some well-known studies have also shown that calcium antagonists are effective against CVD. 37 In DM2 patients, either of these treatments could be considered the most appropriate choice, alone or in combination.…”

Section: Treatment Of High Blood Pressurementioning

confidence: 99%

Obesity, Metabolic Syndrome, and Diabetes: Cardiovascular Implications and Therapy

Ezquerra¹,

Castellano²,

Barrero³

2008

Revista Española de Cardiología (English Edition)

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Obesity, metabolic syndrome, and type-2 diabetes mellitus are 3 interrelated conditions that share a number of pathophysiological mechanisms and that are frequently observed to lead, in succession, to cardiovascular complications. The fact that their prevalence is increasing alarmingly should prompt all healthcare professionals urgently to implement measures to prevent these complications. The most effective, though also the least adopted, are those related to lifestyle modification. Drug treatment targeted at controlling risk factors (eg, hypertension, dyslipidemia, and thrombophilia), metabolic abnormalities, and excess weight is also necessary. Obesidad, síndrome metabólico y diabetes: implicaciones cardiovasculares y actuación terapéuticaObesidad, síndrome metabólico y diabetes mellitus tipo 2 son tres enfermedades interrelacionadas que comparten mecanismos de aparición y evolución y con frecuencia se van combinando sucesivamente y ocasionan complicaciones cardiovasculares. Su prevalencia crece alarmantemente y debería impeler a los profesionales de la salud y a los gestores a implantar medidas urgentes para prevenir la aparición de complicaciones. Las más eficaces, aunque menos practicadas, son las relacionadas con el estilo de vida. También son necesarios tratamientos farmacológicos destinados al control de los factores de riesgo (hipertensión, dislipemias, trombofilia), las alteraciones metabólicas y el propio exceso de peso.Palabras clave: Diabetes. Síndrome metabólico. Obesidad.

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“…The results of the initial assessments have been published previously 12,21 and the current article summarizes the follow-up data. In the first clinical consultation, a complete physical examination was performed, including the assessment of body weight, height, and blood pressure according to standard guidelines 26 ; and a venous blood sample was drawn for blood chemistry and DNA analyses. At the same visit, the first ultrasound baseline scans of the carotid and femoral arteries were performed.…”

mentioning

confidence: 99%

The Role of Immunity and Inflammation in the Progression of Atherosclerosis in Patients With HIV Infection

Coll

Parra

Alonso-Villaverde

et al. 2007

Stroke

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Background and Purpose-The initial steps of atherosclerosis and the entry of HIV into the cell share similar biological mechanisms. Therefore, our hypothesis is that the progression of atherosclerosis in patients with HIV infection can be influenced by variations in genes implicated in both processes. Methods and Results-The progression of atherosclerosis over a 2-year follow-up period was measured as the combined carotid and femoral intima media thickness (IMT) in 141 patients with HIV infection. The ⌬IMT (IMT follow-up ϪIMT baseline ) values were used to segregate patients as minimal progressors or regressors (lowest ⌬IMT tertile), slow progressors (mid ⌬IMT tertile), and rapid progressors (highest ⌬IMT tertile). Mutations CCR-5⌬32, CCR-2 64I, MCP-1-2518G, SDF1-3ЈA, and CX3CR-1 (T280 mol/L and V249I) in the host DNA were determined. Mean age of the patients was 38.96 (SEM: 0.61) and 68.8% were male. The mean ⌬IMT was 0.045 mm (0.01) per year, which represented a significant progression (PϽ0.001) with respect to baseline values. Patients with minimal progression or regression had a significantly (Pϭ0.01) higher CD4 cell count than slow progressors and rapid progressors. Multivariate analyses indicated that age and total cholesterol were positively associated with IMT progression. In contrast, the CD4 cell count, the SDF1-3ЈA, and the CX3CR-1 249 I mutated alleles were associated with lesser IMT progression. Conclusion-The course of atherosclerosis in patients with HIV infection is influenced by polymorphisms in the SDF1 and CX3CR1 genes by metabolic variables and by the CD4 cell count. These data would be of help in assessing therapeutic needs of these patients.

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Actualización (2003) de las Guías de Práctica Clínica de la Sociedad Española de Cardiología en hipertensión arterial

Cited by 62 publications

References 0 publications

Early Arterial Study in the Prediction of Mortality After Acute Ischemic Stroke

Early Arterial Study in the Prediction of Mortality After Acute Ischemic Stroke

Obesity, Metabolic Syndrome, and Diabetes: Cardiovascular Implications and Therapy

The Role of Immunity and Inflammation in the Progression of Atherosclerosis in Patients With HIV Infection

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