Actual status of AIDS-related lymphoma management in Japan

Nagai, Hirokazu; Iwasaki, Nami; Odawara, Takashi; Okada, Seiji

doi:10.1007/s12185-008-0073-8

Cited by 7 publications

(7 citation statements)

References 7 publications

(7 reference statements)

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“…However, the cumulative number of HIV/AIDS cases is certainly increasing, and the diagnosis and management of HIV-associated lymphoma, including the rare variant of HIV-PTCL, will be among the critical problems to be resolved in Japan in the near future (2). The present case and previous reports suggest that patients with HIV-PTCL display a highly aggressive clinical course (4, 5).…”

Section: Discussionmentioning

confidence: 60%

“…Lymphoma is the most common disease in patients with acquired immune deficiency syndrome (AIDS)-defining malignancy (1,2), and the incidence of non-Hodgkin lymphoma (NHL) is 60-200 times higher in human immunodeficiency virus (HIV)-positive patients (3). The majority of HIV-associated lymphomas have a B-cell phenotype, including Burkitt's lymphoma and diffuse large B-cell lymphoma, as well as Hodgkin lymphoma (3).…”

Section: Introductionmentioning

confidence: 99%

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HIV-associated Peripheral T-cell Lymphoma with a Cytotoxic Phenotype

et al. 2014

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Most human immunodeficiency virus (HIV)-related lymphomas are of B-cell origin, and the T-cell type is very rare. We experienced a Japanese case of HIV-associated peripheral T-cell lymphoma (HIV-PTCL). Sudden intestinal hemorrhage necessitated emergent surgical resection of the small intestine, in which an ulcerative lesion was detected. A histopathological examination revealed large tumor cells in the base of the ulcer, which were immunohistochemically CD30 + , CD56 + , granzyme B + , CD3 + (focally), CD4 -, CD8 -and EBER + . A diagnosis of PTCL, not otherwise specified, was therefore made. The differential diagnosis and significance of Epstein-Barr virus infection are also herein discussed.

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Section: Discussionmentioning

confidence: 60%

Section: Introductionmentioning

confidence: 99%

HIV-associated Peripheral T-cell Lymphoma with a Cytotoxic Phenotype

et al. 2014

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“…In addition, the prevalence of HIV in Japan is much lower than that in the United States and Europe. The physician in charge might not have received the cooperation of HIV/ AIDS experts and missed the appropriate timing for ASCT [22]. Actually, we could not have observed a significant difference between HIV-positive and -negative patients if they received transplantation when they were in CR.…”

Section: Discussionmentioning

confidence: 86%

Impact of HIV Infection on Transplant Outcomes after Autologous Peripheral Blood Stem Cell Transplantation: A Retrospective Study of Japanese Registry Data

Yoshinaga

Kanda

Aisa

et al. 2018

Biology of Blood and Marrow Transplantation

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Autologous stem cell transplantation (ASCT) is a treatment option for HIV-positive patients with non-Hodgkin lymphoma (NHL) and multiple myeloma (MM). However, the prognosis after ASCT in HIV-positive Japanese patients remains unclear. The aim of this study was to evaluate the impact of HIV infection on transplant outcomes after ASCT in Japan. Using the national database of the Japan Society for Hematopoietic Cell Transplantation, we retrospectively evaluated patients with NHL (n = 3862) and MM (n = 2670) who underwent their first ASCT between 2001 and 2014. The presence of HIV antibody was used to diagnose HIV infection. Fifty-six patients with NHL (1.4%) and 23 with MM (.8%) were positive for HIV antibody. Among patients with NHL overall survival (OS) was lower in HIV-positive patients than in HIV-negative patients (5-year OS: HIV-positive patients, 44% versus HIV-negative patients, 65%; P < .001). In a multivariate analysis HIV infection was significantly associated with an increased risk of overall mortality (hazard ratio, 2.30; P < .001). The incidence of relapse was higher in HIV-positive patients (P = .036), whereas there was a similar incidence of nonrelapse mortality (P = .879). OS in patients with MM was similar between those with/without HIV infection (5-year OS: HIV-positive patients, 61% versus HIV-negative patients, 63%; P = .988). HIV infection was associated with a higher risk of overall mortality and relapse after ASCT for NHL in a Japanese population.

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“…In this study, we used PEL cell lines instead of primary PEL cells because the number of AIDS-related lymphoma patients is still low and PEL is extremely rare in Japan (Nagai et al, 2008). In addition, PEL cell lines maintain the features of primary PEL cells and are frequently used as a model of PEL (Drexler et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

Soluble CD30: A Possible Serum Tumor Marker for Primary Effusion Lymphoma

Michai¹,

Goto²,

Hattori³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Background: The serum level of soluble CD30 (sCD30) is known to be increased with several lymphomas and to correlate with prognosis. Primary effusion lymphoma (PEL) is a highly aggressive malignant lymphoma with poor prognosis, but the existence and significance of sCD30 in PEL have not yet been investigated in detail. Objectives: Since the membrane type of CD30 is frequently expressed on the surface of PEL cells, we compared the expression of the membrane type of CD30 and the production of sCD30 among PEL cell lines as well as other lymphomas. Methods: The expression of surface CD30 in various lymphoma cell lines was analyzed with flow cytometry ans sCD30 was quantified by ELISA. Results: Both surface and sCD30 were detected on PEL cell lines as well as on Hodgkin's lymphoma and adult T-cell leukemia/lymphoma cell lines. Surface CD30 and sCD30 levels of each cell lines correlated with each other. Conclusion: The serum level of sCD30 appear to be a useful biological tumor marker for the diagnosis and management of CD30-positive PEL.

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Actual status of AIDS-related lymphoma management in Japan

Cited by 7 publications

References 7 publications

HIV-associated Peripheral T-cell Lymphoma with a Cytotoxic Phenotype

HIV-associated Peripheral T-cell Lymphoma with a Cytotoxic Phenotype

Impact of HIV Infection on Transplant Outcomes after Autologous Peripheral Blood Stem Cell Transplantation: A Retrospective Study of Japanese Registry Data

Soluble CD30: A Possible Serum Tumor Marker for Primary Effusion Lymphoma

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