Actual 10‐year survivors and 10‐year recurrence free survivors after primary liver resection for hepatocellular carcinoma in the 21st century: A single institution contemporary experience

Linn, Yun Le; Chee, Madeline Yen Min; Koh, Ye‐Xin; Teo, Jin‐Yao; Cheow, Peng‐Chung; Chow, Pierce K.H.; Chan, Chung‐Yip; Chung, Alexander Y. F.; Ooi, London L P J; Goh, Brian K. P.

doi:10.1002/jso.26259

Cited by 12 publications

(8 citation statements)

References 25 publications

(90 reference statements)

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“…The most prevalent type of liver cancer is Hepatocellular carcinoma (HCC) or hepatoma with a median survival time of fewer than six months if untreated, and a five-year survival rate of only 5–9% from the time of diagnosis [ 11 , 12 ]. Since HCC is the sixth most common cancer and the second most common cause of cancer mortality worldwide, establishing an efficient treatment for this type of cancer has never been more urgent [ 13 , 14 , 15 , 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

An Analysis of Microwave Ablation Parameters for Treatment of Liver Tumors from the 3D-IRCADb-01 Database

Radmilović-Radjenović

Bošković

Sabo

et al. 2022

Biomedicines

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Simulation techniques are powerful tools for determining the optimal conditions necessary for microwave ablation to be efficient and safe for treating liver tumors. Owing to the complexity and computational resource consumption, most of the existing numerical models are two-dimensional axisymmetric models that emulate actual three-dimensional cancers and the surrounding tissue, which is often far from reality. Different tumor shapes and sizes require different input powers and ablation times to ensure the preservation of healthy tissues that can be determined only by the full three-dimensional simulations. This study aimed to tailor microwave ablation therapeutic conditions for complete tumor ablation with an adequate safety margin, while avoiding injury to the surrounding healthy tissue. Three-dimensional simulations were performed for a multi-slot microwave antenna immersed in two tumors obtained from the 3D-IRCADb-01 liver tumors database. The temperature dependence of the dielectric and thermal properties of healthy and tumoral liver tissues, blood perfusion, and water content are crucial for calculating the correct ablation time and, thereby, the correct ablation process. The developed three-dimensional simulation model may help practitioners in planning patient-individual procedures by determining the optimal input power and duration of the ablation process for the actual shape of the tumor. With proper input power, necrotic tissue is placed mainly in the tumor, and only a small amount of surrounding tissue is damaged.

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Section: Introductionmentioning

confidence: 99%

An Analysis of Microwave Ablation Parameters for Treatment of Liver Tumors from the 3D-IRCADb-01 Database

Radmilović-Radjenović

Bošković

Sabo

et al. 2022

Biomedicines

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“…These findings are consistent with that reported in the literature. The patient clinicopathological features in this study were typical of the demographics of patients with HCC in the region, with patients being predominantly male and of hepatitis B aetiology [21,22]. While most of our patients had peritoneal metastasis followed by adrenal and bowel metastasis, more data exist in the literature on adrenal metastasis followed by peritoneal metastasis.…”

Section: Discussionmentioning

confidence: 63%

Preoperative Predictors of Futile Resection of Intraabdominal Extrahepatic Metastases from Hepatocellular Carcinoma

et al. 2021

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Background The management of post‐liver resection recurrence is often the life‐limiting factor in HCC treatment. While much has been published on intrahepatic recurrence and lung metastasis, there is a relative lack of data on intraabdominal extrahepatic metastasis (EHM). We sought to evaluate the outcomes of patients post‐resection of intraabdominal EHM and assess preoperative factors predictive of early recurrence post‐metastasectomy. Methods We performed a retrospective review of 25 consecutive patients who underwent metastasectomy for intraabdominal EHM from 2003 to 2016 at our institution. Results Of the 25 cases of EHM, 16 were in the peritoneum, 3 in the adrenal glands, 3 in the large bowel, 1 in the spleen, 1 in the pancreas and 1 in the omentum. Median overall survival was 27 months (IQR 15–89 months). Twenty‐one patients (84%) developed recurrence post‐metastasectomy of EHM of which 12 patients experienced early recurrence within 12 months. The median time to recurrence post‐metastasectomy was 11(IQR 15.5) months. Multivariate analysis demonstrated both hepatitis B (11 (91.6%) versus 4 (44.4%), p = 0.00) status and high tumour grade (8 (66.6%) versus 3 (25%), p = 0.004) to be significant independent predictors of early recurrence. Patients who experienced early recurrence had a significantly shorter median overall survival (18 months (95% CI 12.9–23.0)) compared to those who did not (89 months (95% CI 24.8–153.1), p = 0.004). Conclusion Patients with EHM who underwent metastasectomy had a median overall survival of 27 months. Hepatitis B positivity and high primary tumour grade were preoperative predictors of futile surgery. All 7 patients who had both hepatitis B and high tumour grade experienced early recurrence post‐metastasectomy.

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“…Treatment options, including hepatectomy, local ablation therapy, transcatheter arterial chemoembolization (TACE), systemic therapy, and liver transplantation, are selected based on tumor condition and liver functional reserve 3–6 . Hepatectomy is considered the treatment of choice in patients with early stage HCC without liver cirrhosis 7–9 . Although the management of HCC has substantially improved over the past decade, the prognosis remains poor because of tumor invasiveness, intrahepatic and extrahepatic metastases, and high rate of recurrence after curative resection 10–14 …”

Section: Introductionmentioning

confidence: 99%

Impairment of perioperative activities of daily living is associated with poor prognosis following hepatectomy for hepatocellular carcinoma

Mima

Imai

Kaida

et al. 2022

Journal of Surgical Oncology

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Background The number of cancer patients with impairment of activities of daily living (ADLs) has increased. This study aimed to examine associations of perioperative Barthel index score, a validated measure of ADLs, with survival outcomes following hepatectomy for hepatocellular carcinoma (HCC). Methods We analyzed data of 492 consecutive patients who underwent hepatectomy for HCC between 2010 and 2018. Pre‐ and postoperative ADLs were assessed using the Barthel index (range, 0–100; higher scores indicate greater independence). Preoperative Barthel index score ≤85 or postoperative Barthel index score ≤85 was defined as impairment of perioperative ADLs. Cox proportional hazards regression was used to calculate hazard ratios (HRs) after adjusting for potential confounders. Results Among the 492 patients, 26 (5.2%) had a preoperative Barthel index score ≤85 and 95 (19%) had a postoperative Barthel index score ≤85. Impairment of perioperative ADLs was independently associated with shorter overall survival (multivariable HR: 1.75, 95% confidence interval [CI]: 1.06–2.81, p = 0.028). The association of impairment of perioperative ADLs with recurrence‐free survival was not statistically significant. Conclusion Impairment of perioperative ADLs is associated with poor prognosis following hepatectomy for HCC. Maintenance and improvement of perioperative ADLs would be important to provide favorable long‐term outcomes in patients with HCC.

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Actual 10‐year survivors and 10‐year recurrence free survivors after primary liver resection for hepatocellular carcinoma in the 21st century: A single institution contemporary experience

Cited by 12 publications

References 25 publications

An Analysis of Microwave Ablation Parameters for Treatment of Liver Tumors from the 3D-IRCADb-01 Database

An Analysis of Microwave Ablation Parameters for Treatment of Liver Tumors from the 3D-IRCADb-01 Database

Preoperative Predictors of Futile Resection of Intraabdominal Extrahepatic Metastases from Hepatocellular Carcinoma

Impairment of perioperative activities of daily living is associated with poor prognosis following hepatectomy for hepatocellular carcinoma

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