Acts of appetite: neural circuits governing the appetitive, consummatory, and terminating phases of feeding

Alcantara, Ivan C.; Tapia, Ana Pamela Miranda; Aponte, Yeka; Krashes, Michael J.

doi:10.1038/s42255-022-00611-y

Cited by 44 publications

(33 citation statements)

References 214 publications

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“…Antibody tagging of MCH first involved washing the brain sections on a motorized rotating platform in the following order (overnight incubations on a motorized rotating platform at 4 °C): [1] 0.02 M KPBS (change KPBS every 5min for 30min), [2] 0.3% Triton X-100 in KPBS (30 min), [3] KPBS (change KPBS every 5min for 15min), [4] 2% donkeyserum in KPBS (10 min), [5] 2% normal donkey serum, 0.2% sodium azide, and rabbitanti-MCH antibodies [1:2000; rabbit anti-MCH] in KPBS (~24hr) 42 [6] KPBS (change KPBS every 10min for 1 hr), [7] 2% normal donkey serum, 0.2% sodium azide, and secondary antibodies (1:1000; donkey anti-rabbit AF647,Jackson Immunoresearch; overnight) in KPBS (~30hr). [8] KPBS (change KPBS ever 2min for 4min).…”

Section: Discussionmentioning

confidence: 99%

“…Animals were trained in the Pavlovian-Instrumental-Transfer (PIT) task, which measures instrumental appetitive actions in response to discrete food-predictive cues under conditions where food is not available 23,24 . PIT consists of 4 phases: [1] Pavlovian discrimination conditioning, [2] instrumental conditioning, [3] instrumental extinction and [4] PIT test day. On test day, animals recieve intraperitoneal (IP) injections of Deschloroclozapine (DCZ; DREADDs ligand) or vehicle (1% DMSO in 99% saline) to selectively increase MCH neuron activity (Fig.…”

Section: Activation Of Mch Neurons Increases Appetitive Responses To ...mentioning

confidence: 99%

“…Caloric regulation is determined by the integration of appetitive food-motivated responses and consummatory physiological processes that govern meal size [1][2][3] . Once eating is initiated, the amount of calories consumed during a meal is regulated by two opposing processes: an early meal positive feedback process known as appetition that promotes further consumption 3,4 , and a later meal negative feedback process known as satiation that leads to meal termination 1 .…”

Section: Introductionmentioning

confidence: 99%

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Hypothalamic melanin-concentrating hormone neurons integrate food-motivated appetitive and consummatory processes

Subramanian

Lauer

Hayes

et al. 2022

Preprint

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The lateral hypothalamic area (LHA) integrates homeostatic processes and reward-motivated behaviors. Here we show that LHA neurons that produce melanin-concentrating hormone (MCH) are dynamically responsive to both food-directed appetitive and consummatory processes. Specifically, our results reveal that MCH neuron Ca+2 activity increases in response to both discrete and contextual food-predictive cues and is correlated with food-motivated responses. MCH neuron activity also increases during eating and this response is highly predictive of caloric consumption and declines throughout a meal, thus supporting a role for MCH neurons in the positive feedback consummatory process known as appetition. These physiological MCH neural responses are functionally-relevant as chemogenetic MCH neuron activation promotes appetitive behavioral responses to food-predictive cues and increases meal size. Finally, MCH neuron activation enhances preference for a noncaloric flavor paired with intragastric glucose. Collectively, these data identify a hypothalamic neural population that orchestrates both food-motivated appetitive and intake-promoting consummatory processes.

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Section: Discussionmentioning

confidence: 99%

Section: Activation Of Mch Neurons Increases Appetitive Responses To ...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Hypothalamic melanin-concentrating hormone neurons integrate food-motivated appetitive and consummatory processes

Subramanian

Lauer

Hayes

et al. 2022

Preprint

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“…Hunger is a physiological state that induces homeostatic feeding in order to gain energy. Decades of research have revealed a great deal on the hormonal and hypothalamic control of food intake and metabolism [ 1 , 2 , 3 , 4 ]. The neuropeptide Y (NPY)/agouti-related protein (AGRP)-expressing, pro-opiomelanocortin (POMC)-expressing and melanocortin receptor-expressing neurons in the arcuate nucleus of hypothalamus are central to food and appetite regulation [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Acute Fasting Modulates Food-Seeking Behavior and Neural Signaling in the Piriform Cortex

Ngo

Zhang

et al. 2022

Nutrients

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It is well known that the state of hunger can modulate hormones and hypothalamic neural circuits to drive food-seeking behavior and consumption. However, the role the sensory cortex plays in regulating foraging is much less explored. Here, we investigated whether acute fasting in mice can alter an odor-guided foraging behavior and how it can alter neurons and synapses in the (olfactory) piriform cortex (PC). Acute hunger enhances the motivation of a mouse to search for food pellets and increases food intake. The foraging behavior strongly activates the PC, as revealed by c-Fos immunostaining. The activation of PC is accompanied by an increase in excitation–inhibition ratio of synaptic density. Fasting also enhances the phosphorylation of AMP kinase, a biochemical energy regulator. Taken together, our results uncover a new regulatory brain region and implicate the PC in controlling foraging behavior.

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“…The mesolimbic dopamine system is an evolutionarily conserved set of circuits that plays a role in approach and avoidance, appetitive behavior, and reward processing (Wise, 2004; Everitt and Robbins, 2005; Alcantara et al, 2022). In this circuitry, ascending dopaminergic projections from the ventral midbrain, including the ventral tegmental area (VTA), innervate targets throughout the limbic forebrain, such as the ventral striatum/nucleus accumbens (NAc).…”

Section: Introductionmentioning

confidence: 99%

Ventral striatal dopamine encodes unique properties of visual stimuli in mice

Gonzalez

Fisher

D'Souza

et al. 2022

Preprint

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Previously, we used the genetically encoded dopamine sensor dLight1 to show that mice modeling the neurodevelopmental disorder neurofibromatosis type 1 (NF1) have enhanced dopaminergic responses to salient visual stimuli in the lateral nucleus accumbens/ventral striatum (LNAc), as well as more vigorous behavioral responses to visual threats (Robinson et al., 2019). Here, we sought to better understand the nature of this phenotype by testing the ability of striatal dopamine release to encode the properties of sensory stimuli, including threatening looming discs, in typically developing mice. In this Research Advance, we report that ventral striatum dopamine release encodes the rate and magnitude of environmental luminance changes rather than the perceived threat intensity of the stimulus. These visually-evoked dopamine responses are wavelength-dependent at low irradiances, independent of the circadian cycle, and relatively robust to previous exposure history. Thus, we have further elaborated the mesolimbic dopamine system's ability to encode visual information in mice, which may be altered in neurodevelopmental disease models.

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Acts of appetite: neural circuits governing the appetitive, consummatory, and terminating phases of feeding

Cited by 44 publications

References 214 publications

Hypothalamic melanin-concentrating hormone neurons integrate food-motivated appetitive and consummatory processes

Hypothalamic melanin-concentrating hormone neurons integrate food-motivated appetitive and consummatory processes

Acute Fasting Modulates Food-Seeking Behavior and Neural Signaling in the Piriform Cortex

Ventral striatal dopamine encodes unique properties of visual stimuli in mice

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