Actomyosin contractility modulates Wnt signaling through adherens junction stability

Hall, Eric T.; Hoesing, Elizabeth A.; Sinkovics, Endre; Verheyen, Esther M.

doi:10.1091/mbc.e18-06-0345

Cited by 13 publications

(9 citation statements)

References 68 publications

(103 reference statements)

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“…5 E,F). These results are in agreement with studies showing that increased compression transduced by apical junctions in epithelial cells prevent β-catenin nuclear accumulation 11 , 16 . Together, these results thus show that the loss of MAGI1 in luminal BCa cells does not promote YAP nor β-catenin signaling, and suggest that these pathways do not mediate the increased tumorigenicity of MAGI1 deficient cells.…”

Section: Resultssupporting

confidence: 93%

MAGI1 inhibits the AMOTL2/p38 stress pathway and prevents luminal breast tumorigenesis

Kantar

Mur

Mancini

et al. 2021

Sci Rep

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Alterations to cell polarization or to intercellular junctions are often associated with epithelial cancer progression, including breast cancers (BCa). We show here that the loss of the junctional scaffold protein MAGI1 is associated with bad prognosis in luminal BCa, and promotes tumorigenesis. E-cadherin and the actin binding scaffold AMOTL2 accumulate in MAGI1 deficient cells which are subjected to increased stiffness. These alterations are associated with low YAP activity, the terminal Hippo-pathway effector, but with an elevated ROCK and p38 Stress Activated Protein Kinase activities. Blocking ROCK prevented p38 activation, suggesting that MAGI1 limits p38 activity in part through releasing actin strength. Importantly, the increased tumorigenicity of MAGI1 deficient cells is rescued in the absence of AMOTL2 or after inhibition of p38, demonstrating that MAGI1 acts as a tumor-suppressor in luminal BCa by inhibiting an AMOTL2/p38 stress pathway.

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Section: Resultssupporting

confidence: 93%

MAGI1 inhibits the AMOTL2/p38 stress pathway and prevents luminal breast tumorigenesis

Kantar

Mur

Mancini

et al. 2021

Sci Rep

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“…The activity of β-catenin as a membrane component may be controlled by other molecules under certain ambient conditions. For example, non-muscle myosin II induces accumulation of cortical F-actin and E-cadherin to the adherens junctions, resulting in corecruitment of β-catenin to the membrane to maintain cellular contraction and inhibition of Wnt signaling due to reduced levels of cytoplasmic β-catenin ( Hall et al, 2019 ). Cytoskeletal networks have also been reported to regulate Wnt signaling activity through plasma membrane domains during differentiation of stem cells ( von Erlach et al, 2018 ).…”

Section: Initiation Of Wnt Signaling At the Plasma Membranementioning

confidence: 99%

Regulation of Wnt Signaling Pathways at the Plasma Membrane and Their Misregulation in Cancer

Azbazdar

Karabicici

Erdal

et al. 2021

Front. Cell Dev. Biol.

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Wnt signaling is one of the key signaling pathways that govern numerous physiological activities such as growth, differentiation and migration during development and homeostasis. As pathway misregulation has been extensively linked to pathological processes including malignant tumors, a thorough understanding of pathway regulation is essential for development of effective therapeutic approaches. A prominent feature of cancer cells is that they significantly differ from healthy cells with respect to their plasma membrane composition and lipid organization. Here, we review the key role of membrane composition and lipid order in activation of Wnt signaling pathway by tightly regulating formation and interactions of the Wnt-receptor complex. We also discuss in detail how plasma membrane components, in particular the ligands, (co)receptors and extracellular or membrane-bound modulators, of Wnt pathways are affected in lung, colorectal, liver and breast cancers that have been associated with abnormal activation of Wnt signaling. Wnt-receptor complex components and their modulators are frequently misexpressed in these cancers and this appears to correlate with metastasis and cancer progression. Thus, composition and organization of the plasma membrane can be exploited to develop new anticancer drugs that are targeted in a highly specific manner to the Wnt-receptor complex, rendering a more effective therapeutic outcome possible.

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“…Arm has dual roles in disk cells: transducing Wg signals (Hall, Hoesing, Sinkovics, & Verheyen, ; Leckband & De Rooij, ) and in cell adhesion via AJs, and thus there is a competition for it. Arm has binding sites for adhesion components such as α ‐catenin, and for transcription control regulators (Bejsovec, ).…”

Section: Mechanotransduction In the Diskmentioning

confidence: 99%

“…In addition to actin, the motor protein NMII also acts in the mechanotranduction pathways, NMII generates the contractile force in the CSK and cortex, and increased NMII leads to increased E‐Cad activity at the AJs (Hall et al, ). The increased E‐Cad binds more Arm and actin, which in turn reduces Wg signaling, increases Wts localization, and increases Yki activity.…”

Section: Mechanotransduction In the Diskmentioning

confidence: 99%

Growth control in the Drosophila wing disk

Gou

Stotsky

Othmer

2020

WIREs Mechanisms of Disease

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The regulation of size and shape is a fundamental requirement of biological development and has been a subject of scientific study for centuries, but we still lack an understanding of how organisms know when to stop growing. Imaginal wing disks of the fruit fly Drosophila melanogaster, which are precursors of the adult wings, are an archetypal tissue for studying growth control. The growth of the disks is dependent on many inter‐ and intra‐organ factors such as morphogens, mechanical forces, nutrient levels, and hormones that influence gene expression and cell growth. Extracellular signals are transduced into gene‐control signals via complex signal transduction networks, and since cells typically receive many different signals, a mechanism for integrating the signals is needed. Our understanding of the effect of morphogens on tissue‐level growth regulation via individual pathways has increased significantly in the last half century, but our understanding of how multiple biochemical and mechanical signals are integrated to determine whether or not a cell decides to divide is still rudimentary. Numerous fundamental questions are involved in understanding the decision‐making process, and here we review the major biochemical and mechanical pathways involved in disk development with a view toward providing a basis for beginning to understand how multiple signals can be integrated at the cell level, and how this translates into growth control at the level of the imaginal disk. This article is categorized under: Analytical and Computational Methods > Computational Methods Biological Mechanisms > Cell Signaling Models of Systems Properties and Processes > Cellular Models

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Actomyosin contractility modulates Wnt signaling through adherens junction stability

Cited by 13 publications

References 68 publications

MAGI1 inhibits the AMOTL2/p38 stress pathway and prevents luminal breast tumorigenesis

MAGI1 inhibits the AMOTL2/p38 stress pathway and prevents luminal breast tumorigenesis

Regulation of Wnt Signaling Pathways at the Plasma Membrane and Their Misregulation in Cancer

Growth control in the Drosophila wing disk

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