Activity-wheel running attenuates suppression of natural killer cell activity after footshock

Dishman, Rod K.; Warren, Jennifer E.; Youngstedt, Shawn D.; Yoo, Hyung Sik; Bunnell, B. N.; Mougey, Edward H.; Meyerhoff, James L.; Jaso-Friedmann, Liliana; Evans, Donald L.

doi:10.1152/jappl.1995.78.4.1547

Cited by 45 publications

(41 citation statements)

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“…This might be accomplished by investigating whether interventions aimed at increasing physical activity can buffer people from the immunologic changes associated with depression. Exercise serves this stress-buffering function in the rat immune response (33). It also will be important for future research to determine the health implications of the immunologic alterations described here and in previous studies.…”

Section: Discussionmentioning

confidence: 69%

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Pathways Linking Major Depression and Immunity in Ambulatory Female Patients

Miller

Cohen

Herbert

1999

Psychosomatic Medicine

124

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Objectives: The goals of this study were to investigate whether depression is associated with cellular immunity in ambulatory patients and to identify neuroendocrine and behavioral pathways that might account for this relationship. Methods: We studied 32 women who met Diagnostic and Statistical Manual of Mental Disorder, fourth edition, criteria for major depressive disorder and 32 healthy female control subjects. The groups were matched for age and ethnicity. None were taking medication, and all were free of disease involving the immune system. Results: Depressed subjects had reduced proliferative responses to the mitogens concanavalin A and phytohemagglutinin compared with control subjects. Natural killer cell activity was reduced among older depressed subjects but enhanced among younger depressed subjects. Although depression was associated with elevated circulating levels of norepinephrine and estradiol, these hormones could not account for the immunologic differences between depressed and control subjects. Depression was also associated with greater tobacco and caffeine consumption, less physical activity, and poorer sleep quality. Mediational analyses were consistent with physical activity acting as a pathway through which depression was associated with reduced lymphocyte proliferation. Conclusions: Ambulatory patients with mild to moderately severe depression exhibit reduced mitogen-stimulated lymphocyte proliferative responses and altered natural killer cell cytotoxicity. The relationship between depression and proliferative responses may be mediated by physical activity.

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Section: Discussionmentioning

confidence: 69%

“…To date, no research has considered whether physical activity might act as a mediator of the link between depression and immunity, despite evidence from the animal literature that exercise can provide a buffer against stress-induced downregulation of NKCC (33).…”

Section: Introductionmentioning

confidence: 99%

Pathways Linking Major Depression and Immunity in Ambulatory Female Patients

Miller

Cohen

Herbert

1999

Psychosomatic Medicine

124

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“…Surprisingly, studies have typically not shown a reliable effect of voluntary physical exercise on glucocorticoid responses to various acute stressor exposures in humans (Sothmann et al 1988) or animals (Dishman 1995(Dishman , 1998Fediuc et al 2006;Fleshner 2000). While it is the situations involving prolonged or repeated stressor exposures that are typically associated with physical and psychological illness, there has been little investigation into the potential for voluntary exercise to alter the way the body and brain respond to repeated stress.…”

Section: Introductionmentioning

confidence: 99%

Chronic voluntary wheel running facilitates corticosterone response habituation to repeated audiogenic stress exposure in male rats

Sasse

Greenwood

Masini

et al. 2008

Stress

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Voluntary exercise is associated with the prevention and treatment of numerous physical and psychological illnesses, yet the mechanisms by which it confers this protection remain unclear. In contrast, stress, particularly under conditions of prolonged or repeated exposure when glucocorticoid levels are consistently elevated, can have a devastating impact on health. It has been suggested that the benefits of physical exercise may lie in an ability to reduce some of the more deleterious health effects of stress and stress hormones. The present series of experiments provides evidence that voluntary exercise facilitates habituation of corticosterone but not adrenocorticotropin hormone responses to repeated stress presentations. After 6 weeks of running wheel access or sedentary housing conditions, rats were exposed to 11 consecutive daily 30 min presentations of 98 dB noise stress. Similar corticosterone responses in exercised rats and sedentary controls were observed following the first, acute stress presentation. While both groups demonstrated habituation of corticosterone secretory responses with repeated noise stress exposures, the rate of habituation was significantly facilitated in exercised animals. These results suggest that voluntary exercise may reduce the negative impact of prolonged or repeated stress on health by enhancing habituation of hypothalamo-pituitary-adrenocortical axis responses at the level of the adrenal cortex, ultimately reducing the amount of glucocorticoids the body and brain are exposed to.

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“…Indeed, stressful events often precipitate and exacerbate psychiatric disorders such as depression and anxiety (Chorpita and Barlow, 1998;Kendler et al, 1999), and, compared with sedentary rats, several weeks of previous, voluntary access to running wheels results in dramatic alterations in immunological (Dishman et al, 1995;Fleshner, 2000;Avula et al, 2001;Moraska and Fleshner, 2001;Fleshner et al, 2002), neurochemical Dishman et al, 1997b;Soares et al, 1999;Greenwood et al, 2003), and behavioral (Dishman et al, , 1997aSolberg et al, 1999;Moraska and Fleshner, 2001) responses to stress.…”

Section: Introductionmentioning

confidence: 99%