Activity of two new potent dopaminergic agonists at the striatal and anterior pituitary levels

Euvrard, C.; Ferland, Louise; Paolo, Thérèse Di; Beaulieu, Martin; Labrie, Fernand; Oberlander, Claude; Raynaud, Jean‐Pierre; Boissier, Jacques R.

doi:10.1016/0028-3908(80)90190-2

Cited by 124 publications

(24 citation statements)

References 18 publications

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“…Lower concentrations (10m5 M) excited FB and inhibited BSN, whereas higher concentrations (above 10e4 M) triggered the feeding motor program. Apomorphine, bromocriptine, and the vertebrate D2 agonists lysuride (Kebabian and Calne, 1979) and RU24213 and RU24926 (Euvrard et al, 1980) were ineffective on FB, BSN, and the Limax feeding system. Figure 7.…”

Section: Resultsmentioning

confidence: 99%

Dopamine elicits feeding motor program in Limax maximus

Wieland¹,

Gelperin²

1983

J. Neurosci.

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A neural system within the cerebral and buccal ganglia of the terrestrial mollusc Limax maximus responds to lip chemostimulation by emitting a feeding motor program (FMP) in uiuo and in uitro. We have analyzed chemically the cerebral and buccal ganglia of Limax for neurotransmitters involved in controlling expression of FMP. Dopamine was found in clusters of cells and in the neuropil of the cerebral ganglia at a concentration of 62 pmol/ganglion; a large proportion of such dopamine-containing cells projected to the lips. The buccal ganglia contained several small dopaminergic cells and large amounts of dopamine in the neuropil; the measured concentration was 10 pmol/ganglion.Exogenous dopamine applied to the cerebral and buccal ganglia in vitro between lop7 M and 3 x lop6 M excited an autoactive salivary duct motor neuron (FB) and inhibited an autoactive secretomotor neuron (BSN). Concentrations of dopamine between 3 X 10m6 M and 3 X 10e5 M triggered FMP output, with an increased probability of triggering at higher concentrations of dopamine. ADTN and SK&F38393 were potent agonists in this system, whereas ergonovine was the only potent antagonist found; none of the neuroleptics tested was effective. Thus, the Limax system shows agonist responses similar to the vertebrate Dl receptors, but its antagonist-binding properties appear to have requirements quite different from vertebrate receptors.The effects of exogenous serotonin differed from dopamine's effects; serotonin excited BSN and several buccal motor neurons, could not elicit synchronized motor program cycling, and was not efficiently blocked by ergonovine.These data suggest that dopamine is a good candidate as an endogenous triggering and sustaining transmitter for the Limax feeding motor program.

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Section: Resultsmentioning

confidence: 99%

Dopamine elicits feeding motor program in Limax maximus

Wieland¹,

Gelperin²

1983

J. Neurosci.

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“…These studies use procedures that both address the abovementioned methodological concerns and, additionally, allow systematic comparison with the phenotype of congenic D 1 , D 2 , and D 3 receptor knockouts, which we have determined using these same procedures McNamara et al, 2002McNamara et al, , 2003. They contrast the effects of the selective D 2 -like receptor agonist RU 24213 (Euvrard et al, 1980;Clifford et al, 2000Clifford et al, , 2001McNamara et al, 2002McNamara et al, , 2003 with those of the selective D 2 -like receptor antagonist YM 09151-2 (Niznik et al, 1985;McNamara et al, 2003) to evaluate shifts in the topography of behavior mediated through D 2 -like receptors, consequent to the absence of DARPP-32.…”

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confidence: 99%

Ethologically Based Resolution of D₂-Like Dopamine Receptor Agonist-versus Antagonist-Induced Behavioral Topography in Dopamine- and Adenosine 3′,5′-Monophosphate-Regulated Phosphoprotein of 32 kDa “Knockout” Mutants Congenic on the C57BL/6 Genetic Background

Nally

Kinsella²,

Tighe³

et al. 2004

J Pharmacol Exp Ther

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Given the critical role of dopamine-and adenosine 3Ј,5Ј-monophosphate-regulated phosphoprotein of 32 kDa in the regulation of dopaminergic function, DARPP-32-null mutant mice congenic on the inbred C57BL/6 strain for 10 generations were examined phenotypically for their ethogram of responsivity to the selective D 2 -like receptor agonist RU 24213 (N-npropyl-N-phenylethyl-p-3-hydroxyphenylethylamine) and the selective D 2 -like receptor antagonist YM 09151-2 (cis-N-[1-benzyl-2-methyl-pyrrolidin-3-yl]-5-chloro-2-methoxy-4-methylaminobenzamide), using procedures that resolve all topographies of behavior in the natural repertoire. After vehicle challenge, levels of sniffing and rearing seated were reduced in DARPP-32 mutants; the injection procedure seems to constitute a "stressor" that reveals phenotypic effects of DARPP-32 deletion not apparent under natural conditions. Topographical effects of 0.3 to 10.0 mg/kg RU 24213, primarily induction of sniffing and ponderous locomotion with accompanying reductions in rearing, grooming, sifting and chewing, were not altered to any material extent in DARPP-32-null mice. However, topographical effects of 0.005 to 0.625 mg/kg YM 09151-2, namely, reduction in sniffing, locomotion, rearing, grooming, and chewing but not sifting, were essentially absent in DARPP-32 mutants. Thus, the D 2 -like receptor agonist-mediated ethogram was essentially conserved, whereas major elements of the corresponding D 2 -like receptor antagonist-mediated ethogram were essentially absent in DARPP-32-null mice. This suggests some relationship between 1) extent of tonic dopaminergic activation of DARPP-32 mechanisms and 2) compensatory mechanisms consequent to the developmental absence of DARPP-32, which may emerge to act differentially on individual elements of the DARPP-32 system. Critically, the present data indicate that phenotypic effects of a given gene deletion using an agonist acting on the system disrupted cannot be generalized to a corresponding antagonist, and vice versa. subtypes in the regulation of mammalian behavior remains uncertain because of delay in the identification of a full range of selective agonists and antagonists by medicinal chemistry relative to the rate of identification of these receptor subtypes by molecular biology (Waddington et al., 1995;Di Chiara, 2002;Sidhu et al., 2003). The construction of mutants with targeted gene deletion ("knockout") of each individual dopamine receptor subtype has provided an important approach to addressing this issue (Sibley, 1999;Waddington et al., 2001). However, elucidation of the

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“…Furthermore, we have contrasted spontaneous behavioural topography with responsivity to the well-established selective D 2 -like agonist RU 24213 (Euvrard et al 1980;Claudi et al 1994;Waddington et al 1995;Clifford et al 1999) and applied the selective D 1 -like agonist A 68930 (DeNinno et al 1991;Daly and Waddington 1993;Waddington et al 1995: Clifford et al 1999) to probe for additional phenotypic effects at the level of D 1 -like: D 2 -like interactions.…”

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confidence: 99%

Comparative, Topographically-Based Evaluation of Behavioural Phenotype and Specification of D1-Like:D2 Interactions in a Line of Incipient Congenic Mice with D2 Dopamine Receptor 'Knockout'

Clifford

Kinsella²,

Tighe

et al. 2001

Neuropsychopharmacology

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Activity of two new potent dopaminergic agonists at the striatal and anterior pituitary levels

Cited by 124 publications

References 18 publications

Dopamine elicits feeding motor program in Limax maximus

Dopamine elicits feeding motor program in Limax maximus

Ethologically Based Resolution of D₂-Like Dopamine Receptor Agonist-versus Antagonist-Induced Behavioral Topography in Dopamine- and Adenosine 3′,5′-Monophosphate-Regulated Phosphoprotein of 32 kDa “Knockout” Mutants Congenic on the C57BL/6 Genetic Background

Comparative, Topographically-Based Evaluation of Behavioural Phenotype and Specification of D1-Like:D2 Interactions in a Line of Incipient Congenic Mice with D2 Dopamine Receptor 'Knockout'

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Activity of two new potent dopaminergic agonists at the striatal and anterior pituitary levels

Cited by 124 publications

References 18 publications

Dopamine elicits feeding motor program in Limax maximus

Dopamine elicits feeding motor program in Limax maximus

Ethologically Based Resolution of D2-Like Dopamine Receptor Agonist-versus Antagonist-Induced Behavioral Topography in Dopamine- and Adenosine 3′,5′-Monophosphate-Regulated Phosphoprotein of 32 kDa “Knockout” Mutants Congenic on the C57BL/6 Genetic Background

Comparative, Topographically-Based Evaluation of Behavioural Phenotype and Specification of D1-Like:D2 Interactions in a Line of Incipient Congenic Mice with D2 Dopamine Receptor 'Knockout'

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Ethologically Based Resolution of D₂-Like Dopamine Receptor Agonist-versus Antagonist-Induced Behavioral Topography in Dopamine- and Adenosine 3′,5′-Monophosphate-Regulated Phosphoprotein of 32 kDa “Knockout” Mutants Congenic on the C57BL/6 Genetic Background