Activity of the Vascular Targeting Agent Combretastatin A-4 Disodium Phosphate in a Xenograft Model of AIDS-Associated Kaposi's Sarcoma

Rojiani, Amyn M.; Li, Lingyun; Rise, Leroy; Siemann, Dietmar W.

doi:10.1080/028418602317314136

Cited by 27 publications

(22 citation statements)

References 25 publications

(34 reference statements)

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“…As previously described by us 11,18,22 and others, 5,6,10,12,20,21 by 24 hr after drug exposure, viable tumor cells were detectable only at the periphery of the tumors adjacent to the surrounding normal tissues (data not shown). These histologic changes were probably the consequence of the rapid and widespread shutdown in vascular function seen in tumors after CA4DP or DMXAA exposure (Fig.…”

Section: Resultssupporting

confidence: 78%

“…Still, this would appear likely as, at least for CA4DP, a similar pattern to that shown in Figure 2 was observed in another xenograft model. 18,26 Initial studies evaluating the combination of vascular targeting agents and conventional chemotherapy focused on determining the dose and schedule of CA4DP and DMXAA required to optimize their efficacy in such a treatment regimen (Figs. 3, 4).…”

Section: Resultsmentioning

confidence: 99%

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Vascular targeting agents enhance chemotherapeutic agent activities in solid tumor therapy

Siemann

Mercer

Lepler

et al. 2002

Intl Journal of Cancer

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150

115

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The utility of combining the vascular targeting agents 5,6-dimethyl-xanthenone-4 acetic acid (DMXAA) and combretastatin A-4 disodium phosphate (CA4DP) with the anticancer drugs cisplatin and cyclophosphamide (CP) was evaluated in experimental rodent (KHT sarcoma), human breast (SKBR3) and ovarian (OW-1) tumor models. Doses of the vascular targeting agents that led to rapid vascular shutdown and subsequent extensive central tumor necrosis were identified. Histologic evaluation showed morphologic damage of tumor cells within a few hours after treatment, followed by extensive hemorrhagic necrosis and dose-dependent neoplastic cell death as a result of prolonged ischemia. Whereas these effects were induced by a range of CA4DP doses (10 -150 mg/kg), the dose response to DMXAA was extremely steep; doses < 15 mg/kg were ineffective and doses > 20 mg/kg were toxic. DMXAA also enhanced the tumor cell killing of cisplatin, but doses > 15 mg/kg were required. In contrast, CA4DP increased cisplatin-induced tumor cell killing at all doses studied. This enhancement of cisplatin efficacy was dependent on the sequence and interval between the agents. The greatest effects were achieved when the vascular targeting agents were administered 1-3 hr after cisplatin. When CA4DP (100 mg/kg) or DMXAA (17.5 mg/ kg) were administered 1 hr after a range of doses of cisplatin or CP, the tumor cell kill was 10 -500-fold greater than that seen with chemotherapy alone. In addition, the inclusion of the antivascular agents did not increase bone marrow stem cell toxicity associated with these anticancer drugs, thus giving rise to a therapeutic gain.

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Section: Resultssupporting

confidence: 78%

Section: Resultsmentioning

confidence: 99%

Vascular targeting agents enhance chemotherapeutic agent activities in solid tumor therapy

Siemann

Mercer

Lepler

et al. 2002

Intl Journal of Cancer

Self Cite

150

115

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“…These data are consistent with the histological assessments of KS xenografts treated with CA4DP; i.e. a 100 mg:kg dose of CA4DP caused both º 90% tumor cell death and necrosis 24 h after treatment (12). Cells that survive the CA4DP treatment are located at the periphery of the tumor in areas supplied by normal tissue blood vessels (12,16).…”

Section: Resultssupporting

confidence: 87%

“…a 100 mg:kg dose of CA4DP caused both º 90% tumor cell death and necrosis 24 h after treatment (12). Cells that survive the CA4DP treatment are located at the periphery of the tumor in areas supplied by normal tissue blood vessels (12,16). In order to eliminate these surviving tumor cells, blastine either alone or in combination with 100 mg:kg CA4DP and their effect on tumor cell kill was evaluated ( Fig.…”

Section: Resultsmentioning

confidence: 99%

“…A large number of agents directed at interfering with the angiogenic process have been developed (7,8) and some of these, including TNP470 and thalidomide, have been used in clinical trials in AIDS-KS patients (9)(10)(11). Another agent, combretastatin A-4 disodium phosphate (CA4DP), currently in Phase I trials, has shown signi cant antivascular activity in a xenograft model of AIDS-KS (12). In the light of these ndings, and given its possible application in an adjuvant setting in this disease, the present investigations were undertaken to explore the potential therapeutic applicability of CA4DP alone or in combination with conventional anticancer therapies to treat KS xenografts.…”

Section: Preclinical Evaluations Of Therapies Combining the Vascular mentioning

confidence: 99%

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Preclinical Evaluations of Therapies Combining the Vascular Targeting Agent Combretastatin A-4 Disodium Phosphate and Conventional Anticancer Therapies in the Treatment of Kaposi's Sarcoma

Rojiani

Siemann

2002

Acta Oncologica

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Remote monitoring and control of horticultural cool storage over the Internet

Omid

Sajjadiye

Alimardani

2011

Comp Applic In Engineering

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ABSTRACT:In this article, a distributed architecture that allows remote control and monitoring of horticultural cool storage (HCS) is presented. The various stages in the design and implementation of system for monitoring temperature and relative humidity and controlling HCS environment conditions are presented and discussed. The required hardware include a microcontroller and accompanying electronic circuitry, a server computer, serial port, temperature and relative humidity sensors and two actuators. Microcontroller transfers the sensors data to the server via serial port. Both the client and the server side programs are coded in VB programming language. They use VB MSComm control in order to communicate with the microcontroller. Internet communications is relied on socket programming. Winsock is used for network communications via the TCP/IP protocol. Sockets are configured to listen to a data port or to connect and then transmit to a remote one. Consequently information can be easily and reliably transmitted, monitored and/or controlled by the two machines. The performance of system was evaluated for 2 weeks and the results were quite satisfactory. This system can be easily adapted in other agricultural facilities such as greenhouses and silos. ß

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Activity of the Vascular Targeting Agent Combretastatin A-4 Disodium Phosphate in a Xenograft Model of AIDS-Associated Kaposi's Sarcoma

Cited by 27 publications

References 25 publications

Vascular targeting agents enhance chemotherapeutic agent activities in solid tumor therapy

Vascular targeting agents enhance chemotherapeutic agent activities in solid tumor therapy

Preclinical Evaluations of Therapies Combining the Vascular Targeting Agent Combretastatin A-4 Disodium Phosphate and Conventional Anticancer Therapies in the Treatment of Kaposi's Sarcoma

Remote monitoring and control of horticultural cool storage over the Internet

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