Activity of the Inflammatory Process in Different Types of Unstable Atherosclerotic Plaques

Abstract

Inflammatory biomarkers and chemoattractants characteristic and important for different types (lipid; inflammatory erosive; degenerative necrotic) of unstable plaques in coronary arteries were identified and studied in male patients with coronary atherosclerosis without acute coronary syndrome we studied. Among the three types of unstable plaques, elevated concentrations of IL-1β, IL-6, IL-8, IL-18 and monocyte chemotactic protein-1 were characteristic of not only inflammatory erosive type, but also lipid type compared with degenerative necrotic type. Thus, intensification of the inflammatory process plays an important role in the development of not only inflammatory and destructive, but also of lipid type of unstable atherosclerotic plaques.

Protective Role of Statins in Patients With Acute Coronary Syndrome Aged ≥75 Years With Low LDL-C Who Underwent Percutaneous Coronary Intervention

“…20 The CRP is an acute-phase reactant that plays a direct role in the inflammatory process by stimulating monocyte release of inflammatory cytokines such interleukin 1 (IL-1), IL-6, and tumor necrosis factor α. 21 The present study revealed that the value of the myocardial biomarkers CK-MB, cTnI, and hsCRP were all significantly increased after PCI, which is in accordance with the other studies, 16,17 indicating that inflammation plays an important role in PCI-related myocardial injury.…”

“…Several cytokines take part in inflammatory reactions in the ACS pathophysiology. 16,17 Myocardial damage during PCI is associated with inflammatory response that significantly correlates with cardiovascular risk. Elderly patients with ACS have a greater incidence of multivessel disease and more diseased vessels; also, they have more comorbidities such as diabetes, hypercholesterolemia, hypertension, and renal disease resulting in higher risk of adverse vascular events.…”

Recombinant human CXCL8(3‐72)K11R/G31P regulates smooth muscle cell proliferation and migration through blockage of interleukin‐8 receptor

“…Treatment of hyperlipidemia may be an important component for the management of atherogenesis in its early stages (2, 3). Several lines of evidence support the notion that atherosclerosis is a chronic inflammatory disease in nature (4–6). The chemokine interleukin‐1β (IL‐1β)/chemokine (C‐X‐C motif) ligand 8 (CXCL8/IL‐8) has been known to play an important role in monocyte migration into the subendothelial space in the early phase of atherosclerosis (7, 8).…”

Detection of Atherosclerotic Plaques in the Rabbit Aorta Using Ultrasound Microbubbles Conjugated to Interleukin-18 Antibodies

“…CD34 was previously used to identify neovessels and was characterized as a marker of atherosclerosis [ 24 ]. In the present study, we observed that atherosclerotic plaques are rich with microvessels.…”