Activity of tea tree oil on methicillin-resistant Staphylococcus aureus (MRSA)

Chan, Chi-fun.; Loudon, K W

doi:10.1016/s0195-6701(98)90267-5

Cited by 17 publications

(9 citation statements)

References 5 publications

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“…There was no difference in the antimicrobial activity of the two brands which was not unexpected given that both manufacturers subscribe to the International Standard, IOS 4730, which sets minimum and maximum concentrations for each of the 15 main components of TTO to standardize products sourced from different producers. Furthermore, the MIC and MBC results for both TTO brands were similar to those reported in previous studies (Carson and Riley 1995; Chan and Loudon 1998; Elsom and Hide 1999).…”

Section: Discussionsupporting

confidence: 89%

Comparison of the cidal activity of tea tree oil and terpinen-4-ol against clinical bacterial skin isolates and human fibroblast cells

Loughlin

Gilmore

McCarron

et al. 2008

Lett Appl Microbiol

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Aims: The aim of this study was to compare both the antimicrobial activity of terpinen‐4‐ol and tea tree oil (TTO) against clinical skin isolates of meticillin‐resistant Staphylococcus aureus (MRSA) and coagulase‐negative staphylococci (CoNS) and their toxicity against human fibroblast cells. Methods and Results: Antimicrobial activity was compared by using broth microdilution and quantitative in vitro time‐kill test methods. Terpinen‐4‐ol exhibited significantly greater bacteriostatic and bactericidal activity, as measured by minimum inhibitory and bactericidal concentrations, respectively, than TTO against both MRSA and CoNS isolates. Although not statistically significant, time‐kill studies also clearly showed that terpinen‐4‐ol exhibited greater antimicrobial activity than TTO. Comparison of the toxicity of terpinen‐4‐ol and TTO against human fibroblasts revealed that neither agent, at the concentrations tested, were toxic over the 24‐h test period. Conclusions: Terpinen‐4‐ol is a more potent antibacterial agent against MRSA and CoNS isolates than TTO with neither agent exhibiting toxicity to fibroblast cells at the concentrations tested. Significance and Impact of the Study: Terpinen‐4‐ol should be considered for inclusion as a single agent in products formulated for topical treatment of MRSA infection. However, further work would initially be required to ensure that resistance would not develop with the use of terpinen‐4‐ol as a single agent.

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Section: Discussionsupporting

confidence: 89%

Comparison of the cidal activity of tea tree oil and terpinen-4-ol against clinical bacterial skin isolates and human fibroblast cells

Loughlin

Gilmore

McCarron

et al. 2008

Lett Appl Microbiol

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“…The MICs and minimal bactericidal concentrations (MBCs) for the Australian isolates were 0.25% and 0.5%, respectively, while those for the United Kingdom isolates were 0.312% and 0.625%, respectively. Subsequent reports on the susceptibility of MRSA to TTO have similarly not shown great differences compared to antibiotic-sensitive organisms (39,58,68,106,115).…”

Section: Antibacterial Activitymentioning

confidence: 93%

Melaleuca alternifolia(Tea Tree) Oil: a Review of Antimicrobial and Other Medicinal Properties

2006

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SUMMARY Complementary and alternative medicines such as tea tree (melaleuca) oil have become increasingly popular in recent decades. This essential oil has been used for almost 100 years in Australia but is now available worldwide both as neat oil and as an active component in an array of products. The primary uses of tea tree oil have historically capitalized on the antiseptic and anti-inflammatory actions of the oil. This review summarizes recent developments in our understanding of the antimicrobial and anti-inflammatory activities of the oil and its components, as well as clinical efficacy. Specific mechanisms of antimicrobial and anti-inflammatory action are reviewed, and the toxicity of the oil is briefly discussed.

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“…20 The minimum bactericidal concentration for tea tree oil observed in our study was also similar to those of previous studies using similar methods. 22,24,25 However, it was much lower than the minimum bactericidal concentrations reported by other studies, indicating the possibility of considerable isolate-to-isolate variation in meticillin-sensitive Staphylococcus aureus susceptibility to tea tree oil and, by assumption, to its principal active component terpinen-4-ol. 6,26 Our cochlear implant meticillin-sensitive S aureus isolate showed susceptibility to a wide selection of antimicrobial agents.…”

Section: Discussionmentioning

confidence: 58%

Treatment of a cochlear implant biofilm infection: a potential role for alternative antimicrobial agents

et al. 2010

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Activity of tea tree oil on methicillin-resistant Staphylococcus aureus (MRSA)

Cited by 17 publications

References 5 publications

Comparison of the cidal activity of tea tree oil and terpinen-4-ol against clinical bacterial skin isolates and human fibroblast cells

Comparison of the cidal activity of tea tree oil and terpinen-4-ol against clinical bacterial skin isolates and human fibroblast cells

Melaleuca alternifolia(Tea Tree) Oil: a Review of Antimicrobial and Other Medicinal Properties

Treatment of a cochlear implant biofilm infection: a potential role for alternative antimicrobial agents

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