Activity of tea tree oil and nerolidol alone or in combination against Pediculus capitis (head lice) and its eggs

Campli, Emanuela Di; Bartolomeo, Soraya Di; Pizzi, Patricia Delli; Giulio, Mara Di; Grande, Rossella; Nostro, Antonia; Cellini, Luigina

doi:10.1007/s00436-012-3045-0

Cited by 69 publications

(51 citation statements)

References 38 publications

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“…As the concentration increased, the failure of egg hatching increased. In addition, the efficient penetration and exposure period are the two important factors that influence the efficiency of the ovicide agent to act on the embryo within the egg shell through highly hydrophobic cuticle [21,37] . Since we cannot evaluate the efficient penetration, we only determined the exposure period of ovicide based on the time of exposure.…”

Section: Discussionmentioning

confidence: 99%

Toxicity and sub-lethal effect of endemic plants from family Anacardiaceae on oviposition behavior of Aedes albopictus

Zuharah

Ling

Zulkifly

et al. 2015

Asian Pacific Journal of Tropical Biomedicine

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Objective: To evaluate the lethal concentration, oviposition deterrence and ovicidal activity of acetone extracts of Melanochyla fasciculiflora (M. fasciculiflora) leaf and Gluta renghas (G. renghas) leaf against Aedes albopictus (Ae. albopictus). Methods: To determine the lethal concentration of Anacardiaceae, ten test concentrations of the extracts ranging from 200 to 650 mg/L were selected for larvicidal bioassays and 25 early fourth instar larvae were exposed to the extracts for 24 h. The sub-lethal concentrations used for oviposition deterrence was the value of LC 25 , LC 50 and LC 75 from above study which is 235 mg/L, 470 mg/L and 705 mg/L for M. fasciculiflora extract and 187.5 mg/L, 375 mg/L and 562.5 mg/L for G. renghas extract, respectively. Twenty gravid Ae. albopictus were allowed to oviposit in different treated concentrations. For oviciding procedure, a total of 300 eggs of Ae. albopictus were soaked in solution with each treated concentration as mentioned above for 24 h. After 24 h, eggs were sieved and soaked in seasoned water, and hatching rates were calculated. For comparison, only seasoned water was used in control experiment. Results: G. renghas demonstrated lower LC 50 value of 372.80 mg/L compared to M. fasciculiflora (467.90 mg/L). The activity index of negative oviposition revealed the deterrent effect and thus, caused a remarkable negative response resulting in oviposition of fewer eggs compared with control (without plant extract). The acetone extract of M. fasciculiflora was more effective than G. renghas extract in displaying oviposition deterrence potential since the latter did not possess the deterring effect within the concentration range tested. However, both plant extracts exhibited excellent oviciding effect as 92.33% of eggs failed to be hatched when treated with 705.0 mg/L of M. fasciculiflora and 86.67% with 562.5 mg/L of G. renghas. The oviposition deterrence and percentage of egg mortality were directly proportional to the concentrations of extracts in both plants tested. Conclusions: These results clearly indicate that the acetone extract of G. renghas could be served as potential larvicide, whereas M. fasciculiflora has better sub-lethal effect for oviposition deterrence and against Ae. albopictus as an oviciding agent.

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Section: Discussionmentioning

confidence: 99%

Toxicity and sub-lethal effect of endemic plants from family Anacardiaceae on oviposition behavior of Aedes albopictus

Zuharah

Ling

Zulkifly

et al. 2015

Asian Pacific Journal of Tropical Biomedicine

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“…Most of the preparation for head lice infestations contains the tea tree oil [94]. The insecticidal activity of tea tree oil is due to its anticholinesterase potential [95] .…”

Section: Anti-licementioning

confidence: 99%

Essential oils used in aromatherapy: A systemic review

Ali

Al-Wabel

Shams³

et al. 2015

Asian Pacific Journal of Tropical Biomedicine

853

476

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A B S T R A C TNowadays, use of alternative and complementary therapies with mainstream medicine has gained the momentum. Aromatherapy is one of the complementary therapies which use essential oils as the major therapeutic agents to treat several diseases. The essential or volatile oils are extracted from the flowers, barks, stem, leaves, roots, fruits and other parts of the plant by various methods. It came into existence after the scientists deciphered the antiseptic and skin permeability properties of essential oils. Inhalation, local application and baths are the major methods used in aromatherapy that utilize these oils to penetrate the human skin surface with marked aura. Once the oils are in the system, they remodulate themselves and work in a friendly manner at the site of malfunction or at the affected area. This type of therapy utilizes various permutation and combinations to get relief from numerous ailments like depression, indigestion, headache, insomnia, muscular pain, respiratory problems, skin ailments, swollen joints, urine associated complications etc. The essential oils are found to be more beneficial when other aspects of life and diet are given due consideration. This review explores the information available in the literature regarding therapeutic, medical, cosmetic, psychological, olfactory, massage aromatherapy, safety issues and different plants used in aromatherapy.

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“…Trans-nerolidol is an important fragrance and flavour (Berger, 2007). Nerolidol also exhibits antiulcer (Klopell et al, 2007), antileishmanial (Arruda et al, 2005) and insect repelling (Di Campli et al, 2012) activities. It is the main component of the essential oil and the biologically active component from fragrant rosewood (Dalbergia odorifera; Jiang Xiang in Chinese) heart wood; D. odorifera essential oil is used in Traditional Chinese Medicine for dispersing blood stasis in organs/tissues, and applied for treating coronary heart disease and angina pectoris (Li et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

A squalene synthase protein degradation method for improved sesquiterpene production in Saccharomyces cerevisiae

Peng

Plan

Chrysanthopoulos

et al. 2017

Metabolic Engineering

100

128

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A squalene synthase protein degradation method for improved sesquiterpene production in Saccharomyces cerevisiae, Metabolic Engineering, http://dx.doi.org/10. 1016/j.ymben.2016.12.003 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. AbstractSesquiterpenes are C15 isoprenoids with utility as fragrances, flavours, pharmaceuticals, and potential biofuels. Microbial fermentation is being examined as a competitive approach for bulk production of these compounds. Competition for carbon allocation between synthesis of endogenous sterols and production of the introduced sesquiterpene limits yields. Achieving balance between endogenous sterols and heterologous sesquiterpenes is therefore required to achieve economical yields. In the current study, the yeast Saccharomyces cerevisiae was used to produce the acyclic sesquiterpene alcohol, trans-nerolidol. Nerolidol production was first improved by enhancing the upstream mevalonate pathway for the synthesis of the precursor farnesyl pyrophosphate (FPP). However, excess FPP was partially directed towards squalene by squalene synthase (Erg9p), resulting in squalene accumulation to 1 % biomass; moreover, the specific growth rate declined. In order to redirect carbon away from sterol production and towards the desired heterologous sesquiterpene, a novel protein destabilisation approach was developed for Erg9p. It was shown that Erg9p is located on endoplasmic reticulum and lipid droplets through a C-terminal ER-targeted transmembrane peptide. 2A PEST (rich in Pro, Glu/Asp, Ser, and Thr) sequence-dependent endoplasmic reticulum-associated protein degradation (ERAD) mechanism was established to decrease cellular levels of Erg9p without relying on inducers, repressors or specific repressing conditions. This improved nerolidol titre by 86 % to ~100 mg L -1 . In this strain, squalene levels were similar to the wild-type control strain, and downstream ergosterol levels were slightly decreased relative to the control, indicating redirection of carbon away from sterols and towards sesquiterpene production. There was no negative effect on cell growth under these conditions. Protein degradation is an efficient mechanism to control carbon allocation at flux-competing nodes in metabolic engineering applications. This study demonstrates that an engineered ERAD mechanism can be used to balance flux competition between the endogenous sterol pathway and an introduced bio-product pathways at the FPP node. The approach of protein degradation in general might be more widely applied to improve metabolic engineering outcomes.

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Activity of tea tree oil and nerolidol alone or in combination against Pediculus capitis (head lice) and its eggs

Cited by 69 publications

References 38 publications

Toxicity and sub-lethal effect of endemic plants from family Anacardiaceae on oviposition behavior of Aedes albopictus

Toxicity and sub-lethal effect of endemic plants from family Anacardiaceae on oviposition behavior of Aedes albopictus

Essential oils used in aromatherapy: A systemic review

A squalene synthase protein degradation method for improved sesquiterpene production in Saccharomyces cerevisiae

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