Activity of some platinum(II/IV) complexes with O,O-n-butyl-and O,O-n-pentyl-ethylenediamine-N,N′-di-3-propanoate and halogeno ligands against HeLa and K562 cell lines and human PBMC

Platinum Complexes with Edda (Ethylenediamine -N, N - Diacetate) Ligands as Potential Anticancer Agents

“…These complexes have temperate cytotoxic effects, through they were significantly lower than those of cisplatin and JM-216. It has been proven that platinum(II)/(IV) complexes with multidentate ligands N-(2-hydroxyethyl)ethane-1,2-diamine (49). There is a high probability that difference in effects stems from otherwise complex geometry.…”

“…These two complexes will obtain dissimilar adducts with cell molecules (DNA nucleic bases) by direct interaction. However, if reduction process (Pt(IV) to Pt(II)) occurs before interaction with nucleic bases, trans-[PtX 2 (eddp)] complexes will form tetracoordinated platinum(II) complexes where eddp ligand occupies all four coordination positions preventing in that way reaction with DNA nucleic bases (49 )]) have demonstrated that these complexes had five times weaker cytotoxic effect on HeLa (human cervix adenocarcinoma) cell line compared to cisplatin, but the effect on K562 (human myelogenous leukemia) cell line was almost equal to the effect of cisplatin (Table 1) (50). It was concluded that the exchange of two chloro ions for two iodo ions in pres-1411HP cell line.…”

Novel platinum(IV) complexes induce rapid tumor cell death in vitro

“…Platinum ( 12 Cisplatin complex 9 was prepared according to the procedure described by Boreham et al 13 …”

“…5,6 In the present study, we tested the in vitro antitumor activity of several recently described Pt(II) and Pt(IV) complexes. [7][8][9][10][11][12] The complexes 1-4, [Pt(ONNO)X 2 ] (ONNO 5 pdda-propylenediamine-N,N 0 -diacetato or eddp-ethylenediamine-N,N 0 -di-3-propanoato; X 5 Cl or Br ligands), are characterized with X-ray crystallography in order to determine geometrical isomer, which in all cases were trans-halogeno. This configuration permitted us to investigate and compare how the modification of linear tetradentate affects the cytotoxic action.…”

Part XVI - Stereospecific ligands and their complexes. Synthesis, characterization and in vitro antiproliferative activity of new platinum(IV) complexes with some O,O'-dialkyl esters of (S,S)-ethylenediamine-N,N'-di-2-propanoic acid against breast cancer

“…Also, platinum(IV) complexes are kinetically more inert than platinum(II) complexes, which allows them to be administered orally, reducing toxicity during platinum-based chemotherapy. Recently, several platinum(IV) complexes containing alkyl esters of edda-type ligands (edda = ion of ethylenediamine-N,N'-diacetic acid) have been tested against different cancer cells [11][12][13][14][15][16][17][18], which indicated these complexes exhibited significantly greater cytotoxicity than cisplatin. These studies also brought to the forefront the possibility for the synthesis of platinum(IV)/alkyl ester complexes.…”