Activity of Quinones on <i>Colletotrichum </i>Species

Meazza, G.; Dayan, Franck E.; Wedge, David E.

doi:10.1021/jf0343229

Cited by 83 publications

(62 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Finally, Guerrero-Rodriguez et al (2007) achieved a 93% growth inhibition of C. gloeosporioides with methanolchloroform extracts of Flourensia cernua. With regard to the use of essential oils of different plants, some reports showed inhibition percentages between 50% and 60% (Meepagala et al 2002;Meazza et al 2003). Somda et al (2007) reported a significant inhibition of C. gloeosporioides and Colletotrichum graminicola with lemongrass, eucalyptus, and neem essential oils at concentrations near 1,000 mg/L.…”

Section: Antifungal Assaymentioning

confidence: 99%

“…Nevertheless, C. gloeosporioides has developed resistance to some synthetic chemical fungicides such as benzimidazoles and quinones (Meazza et al 2003). On the other hand, the increasing demand for more "natural" food has led the research for alternative antimicrobial agents within the food industry (Davidson 1997;López-Malo et al 2000;Guynot et al 2005).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of Different Mexican Plant Extracts to Control Anthracnose

Avila-Sosa

Gastélum-Reynoso

García-Juárez

et al. 2010

Food Bioprocess Technol

View full text Add to dashboard Cite

The fungal plant infection caused by Colletotrichum gloeosporioides known as anthracnose, affects tropical fruits thus causing low yield and poor fruit quality. The antifungal activity of ethanol and chloroform extracts of different Mexican plants jarilla (Baccharis salicifolia), tepozan (Buddleia americana), nanche (Byrsonima cordata), cinco negritos (Lantana camara), Mexican oregano (Lippia berlandieri var. Scanner), and pericon (Tagetes lucida) against C. gloeosporioides were evaluated by determining the minimum inhibitory concentration (MIC) of the ethanol and chloroform extracts. Subsequently, an antifungal assay was carried out by determining the inhibition of radial growth in PDA plates added with plant extracts. Jarilla, oregano, and pericon MIC values were 400 mg/L for ethanol extracts and 200 mg/L for chloroform extracts. Tepozan, nanche, and cinco negritos showed no antifungal effect. Concerning the inhibition of radial growth, pericon ethanol extract showed an 84% inhibition; chloroform extracts of jarilla, oregano, and pericon showed 88%, 90%, and 95% inhibition, respectively. The ethanol extracts of oregano and jarilla demonstrated to be inhibitory at the reproductive phase of C. gloeosporioides, while their chloroform extracts have a fungistatic effect.

show abstract

Section: Antifungal Assaymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of Different Mexican Plant Extracts to Control Anthracnose

Avila-Sosa

Gastélum-Reynoso

García-Juárez

et al. 2010

Food Bioprocess Technol

View full text Add to dashboard Cite

show abstract

“…More recently, systematic studies of naphthoquinone derivatives have revealed compounds with anticancer (O'Brien, 1991;Lamson and Plaza, 2003;Taper et al, 2004), antifungal (Meazza et al, 2003, Tandon et al, 2004, antibacterial (Medina et al, 2004, Machado et al, 2003, antithrombotic (Jin et al, 2004) and antiparasitic (Kayser et al, 2003) activity, which may be valuable for use in conventional medicine.…”

Section: Introductionmentioning

confidence: 99%

Structure‐activity relationships in the haemolytic activity and nephrotoxicity of derivatives of 1,2‐ and 1,4‐naphthoquinone

Munday

Smith

Munday

2007

J of Applied Toxicology

View full text Add to dashboard Cite

Naphthoquinone derivatives are under investigation as potential therapeutic agents. Some such compounds are known, however, to be toxic to both animals and humans. Many naphthoquinone derivatives are haemolytic agents, while others cause necrosis of tubular epithelial cells. In the present study, the short-term toxicity of 16 derivatives of 1,2- and 1,4-naphthoquinone has been examined in rats in order to give information on structure-activity relationships. All the naphthoquinones except one caused haemolytic anaemia, but only hydroxy and amino derivatives were nephrotoxic. Among derivatives of 2-amino-1,4-naphthoquinone, substitution in the 3-position decreased haemolytic activity and abolished nephrotoxicity. Methylation of the hydroxyl group of 2-hydroxy-1,4-naphthoquinone had a similar effect. In contrast, methylation of the amino group of 2-amino-1,4-naphthoquinone increased the severity of both haemolysis and renal damage. Among the 1,2-naphthoquinones tested, the 4-methoxy and 4-amino derivatives were more toxic than the corresponding 1,4-isomers, although 4-methyl-1,2-naphthoquinone was less toxic than 2-methyl-1,4-naphthoquinone. At present, the toxicity of naphthoquinone derivatives cannot accurately be predicted on the basis of their chemical structure. In developing naphthoquinone derivatives for use in humans, toxicological studies in animals should be conducted at an early stage, bearing in mind that clinical studies have shown that humans appear to be particularly vulnerable to the nephrotoxic action of these compounds, and that certain individuals are unusually susceptible to their haemolytic action.

show abstract

“…In this connection, it was of interest that 1,2-naphthoquinone (ortho) was reported to be less active than its isomer, 1,4-naphthoquinone (para) against filamentous fungi, Colletrichum spp. 9 The vapor activity of quinones was examined using an agar vapor assay and a box vapor assay; the results are shown in Table 2 together with the activity by agar diffusion assay. The agar vapor assay detected this activity not only of a highly volatile compound but also of a poorly volatile compound, because the distance from the origin of the vapor to the organism was very small (4 mm).…”

mentioning

confidence: 99%